Association of HLA antigens and BCR-ABL transcripts in leukemia patients with the Philadelphia chromosome

• Autor(a) principal: Carvalho,Daiana Landenberger de
• Data de Publicação: 2012
• Outros Autores: Barbosa,Cristian Dias, Carvalho,André Luiz de, Beck,Sandra Trevisan
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista brasileira de hematologia e hemoterapia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842012000400012
• topic: HLA antigens; Fusion proteins, BCR-ABL; Genetic predisposition to disease; Philadelphia chromosome; Leukemia, myelogenous, chronic, BCR-ABL positive; Precursor cell lymphoblastic leukemia-lymphoma

OBJECTIVE: This study aimed to verify the association between human leukocyte antigens and the bcr-abl fusion protein resulting from t(9;22)(q34;q11) in chronic leukemia myeloid and acute lymphoblastic leukemia patients. METHODS: Forty-seven bcr-abl positive individuals were evaluated. Typing was performed bymicrolymphocytotoxicity and molecular biological methods (human leukocyte antigens Class I and Class II). A control group was obtained from the data of potential bone marrow donors registered in the Brazilian Bone Marrow Donor Registry (REDOME). RESULTS: Positive associations with HLA-A25 and HLA-B18 were found for the b2a2 transcript, as well as a tendency towards a positive association with HLA-B40 and a negative association with HLA-A68. The b3a2 transcript showed positive associations with HLA-B40 and HLA-DRB1*3. CONCLUSION: The negative association between human leukocyte antigens and the BCR-ABL transcript suggests that binding and presentation of peptides derived from the chimeric protein are effective to increase a cytotoxic T lymphocyte response appropriate for the destruction of leukemic cells.