Adult acute lymphoblastic leukemia

Detalhes bibliográficos
Autor(a) principal: Foà,Robin
Data de Publicação: 2009
Outros Autores: Chiaretti,Sabina, Guarini,Anna, Vitale,Antonella
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista brasileira de hematologia e hemoterapia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842009000800012
Resumo: This review focuses on the most recent advances in the diagnostic and prognostic work-up of adult acute lymphoblastic leukemia (ALL), and on their implications in the clinical management of the disease. Over the years, information obtained through extensive immunophenotyping, karyotyping, molecular genetics, multidrug resistance and, more recently, genomic profiling is progressively contributing to a better understanding of the biology of this complex disease, to the identification of subgroups of patients with different clinical outcomes, to a more precise monitoring of minimal residual disease, to the use of different therapeutic protocols based on prognostic indicators and, finally, to the design of innovative and specific treatment strategies. The next few years will tell us if this biologically-guided approach, which is progressively individualizing the management of adult ALL patients, will ultimately impact on the prognosis of a disease that has stagnated over many decade.
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spelling Adult acute lymphoblastic leukemiaAcute lymphoblastic leukemiachemotherapyprognostic factorsThis review focuses on the most recent advances in the diagnostic and prognostic work-up of adult acute lymphoblastic leukemia (ALL), and on their implications in the clinical management of the disease. Over the years, information obtained through extensive immunophenotyping, karyotyping, molecular genetics, multidrug resistance and, more recently, genomic profiling is progressively contributing to a better understanding of the biology of this complex disease, to the identification of subgroups of patients with different clinical outcomes, to a more precise monitoring of minimal residual disease, to the use of different therapeutic protocols based on prognostic indicators and, finally, to the design of innovative and specific treatment strategies. The next few years will tell us if this biologically-guided approach, which is progressively individualizing the management of adult ALL patients, will ultimately impact on the prognosis of a disease that has stagnated over many decade.Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular2009-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842009000800012Revista Brasileira de Hematologia e Hemoterapia v.31 suppl.2 2009reponame:Revista brasileira de hematologia e hemoterapia (Online)instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)instacron:ABHHTC10.1590/S1516-84842009000800012info:eu-repo/semantics/openAccessFoà,RobinChiaretti,SabinaGuarini,AnnaVitale,Antonellaeng2009-09-29T00:00:00Zoai:scielo:S1516-84842009000800012Revistahttp://www.rbhh.org/pt/archivo/https://old.scielo.br/oai/scielo-oai.phpsbhh@terra.com.br||secretaria@rbhh.org1806-08701516-8484opendoar:2009-09-29T00:00Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)false
dc.title.none.fl_str_mv Adult acute lymphoblastic leukemia
title Adult acute lymphoblastic leukemia
spellingShingle Adult acute lymphoblastic leukemia
Foà,Robin
Acute lymphoblastic leukemia
chemotherapy
prognostic factors
title_short Adult acute lymphoblastic leukemia
title_full Adult acute lymphoblastic leukemia
title_fullStr Adult acute lymphoblastic leukemia
title_full_unstemmed Adult acute lymphoblastic leukemia
title_sort Adult acute lymphoblastic leukemia
author Foà,Robin
author_facet Foà,Robin
Chiaretti,Sabina
Guarini,Anna
Vitale,Antonella
author_role author
author2 Chiaretti,Sabina
Guarini,Anna
Vitale,Antonella
author2_role author
author
author
dc.contributor.author.fl_str_mv Foà,Robin
Chiaretti,Sabina
Guarini,Anna
Vitale,Antonella
dc.subject.por.fl_str_mv Acute lymphoblastic leukemia
chemotherapy
prognostic factors
topic Acute lymphoblastic leukemia
chemotherapy
prognostic factors
description This review focuses on the most recent advances in the diagnostic and prognostic work-up of adult acute lymphoblastic leukemia (ALL), and on their implications in the clinical management of the disease. Over the years, information obtained through extensive immunophenotyping, karyotyping, molecular genetics, multidrug resistance and, more recently, genomic profiling is progressively contributing to a better understanding of the biology of this complex disease, to the identification of subgroups of patients with different clinical outcomes, to a more precise monitoring of minimal residual disease, to the use of different therapeutic protocols based on prognostic indicators and, finally, to the design of innovative and specific treatment strategies. The next few years will tell us if this biologically-guided approach, which is progressively individualizing the management of adult ALL patients, will ultimately impact on the prognosis of a disease that has stagnated over many decade.
publishDate 2009
dc.date.none.fl_str_mv 2009-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842009000800012
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-84842009000800012
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dc.publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
dc.source.none.fl_str_mv Revista Brasileira de Hematologia e Hemoterapia v.31 suppl.2 2009
reponame:Revista brasileira de hematologia e hemoterapia (Online)
instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
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reponame_str Revista brasileira de hematologia e hemoterapia (Online)
collection Revista brasileira de hematologia e hemoterapia (Online)
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