Relationship between splenomegaly and hematologic findings in patients with hepatosplenic schistosomiasis

Detalhes bibliográficos
Autor(a) principal: Leite,Luiz Arthur Calheiros
Data de Publicação: 2013
Outros Autores: Domingues,Ana Lucia Coutinho, Lopes,Edmundo Pessoa, Ferreira,Rita de Cassia dos Santos, Pimenta Filho,Adenor de Almeida, Fonseca,Caique Silveira Martins da, Santos,Bianka Santana dos, Lima,Vera Lucia de Menezes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista brasileira de hematologia e hemoterapia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000500332
Resumo: BACKGROUND Schistosomiasis is a tropical disease. Patients who develop hepatosplenic schistosomiasis have clinical findings including periportal fibrosis, portal hypertension, cytopenia, splenomegaly and gastrointestinal hemorrhage. OBJECTIVE The aim of this study was to analyze the hemostatic and hematologic findings of patients with schistosomiasis and correlate these to the size of the spleen. METHODS Fifty-five adults with hepatosplenic schistosomiasis and 30 healthy subjects were selected through a history of contact with contaminated water, physical examination and ultrasound characteristics such as periportal fibrosis and splenomegaly in the Gastroenterology Service of the Universidade Federal de Pernambuco. Blood samples were collected to determine liver function, blood counts, prothrombin (international normalized ratio), partial thromboplastin time and fibrinogen and D-Dimer levels using the Pentra 120 hematological analyzer (HORIBA/ABX), Density Plus (test photo-optical Trinity Biotech, Ireland) and COBAS analyzer 6000 (Roche). Furthermore, the longitudinal size of the spleen was measured by ultrasound (Acuson X analyzer 150, Siemens). The Student t-test, the Fisher test and Pearson's correlation were used to analyze the results with statistical significance being set for a p-value < 0.05. RESULTS The mean age was higher for the Study Group than for the Control Group (54 ± 13.9 vs. 38 ± 12.7 years). The average longitudinal diameter of the spleen was 16.9 cm (Range: 12.3-26.3 cm). Anemia is a common finding in patients with schistosomiasis (36.3%). The mean platelet and leukocyte counts of patients were lower than for the Control Group (p-value < 0.001). Moreover, the international normalized ratio (1.42 vs. 1.04), partial thromboplastin time (37.9 vs. 30.5 seconds) and D-Dimer concentration (393 vs. 86.5 ng/mL) were higher for the Study Group compared to the Control Group. CONCLUSION This study suggests that hematological and hemostatic abnormalities are associated with splenomegaly, hypersplenism and portal hypertension.
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spelling Relationship between splenomegaly and hematologic findings in patients with hepatosplenic schistosomiasisSchistosomiasis mansoniSchistosomiasisSplenomegalyHypersplenismThrombocytopenia BACKGROUND Schistosomiasis is a tropical disease. Patients who develop hepatosplenic schistosomiasis have clinical findings including periportal fibrosis, portal hypertension, cytopenia, splenomegaly and gastrointestinal hemorrhage. OBJECTIVE The aim of this study was to analyze the hemostatic and hematologic findings of patients with schistosomiasis and correlate these to the size of the spleen. METHODS Fifty-five adults with hepatosplenic schistosomiasis and 30 healthy subjects were selected through a history of contact with contaminated water, physical examination and ultrasound characteristics such as periportal fibrosis and splenomegaly in the Gastroenterology Service of the Universidade Federal de Pernambuco. Blood samples were collected to determine liver function, blood counts, prothrombin (international normalized ratio), partial thromboplastin time and fibrinogen and D-Dimer levels using the Pentra 120 hematological analyzer (HORIBA/ABX), Density Plus (test photo-optical Trinity Biotech, Ireland) and COBAS analyzer 6000 (Roche). Furthermore, the longitudinal size of the spleen was measured by ultrasound (Acuson X analyzer 150, Siemens). The Student t-test, the Fisher test and Pearson's correlation were used to analyze the results with statistical significance being set for a p-value < 0.05. RESULTS The mean age was higher for the Study Group than for the Control Group (54 ± 13.9 vs. 38 ± 12.7 years). The average longitudinal diameter of the spleen was 16.9 cm (Range: 12.3-26.3 cm). Anemia is a common finding in patients with schistosomiasis (36.3%). The mean platelet and leukocyte counts of patients were lower than for the Control Group (p-value < 0.001). Moreover, the international normalized ratio (1.42 vs. 1.04), partial thromboplastin time (37.9 vs. 30.5 seconds) and D-Dimer concentration (393 vs. 86.5 ng/mL) were higher for the Study Group compared to the Control Group. CONCLUSION This study suggests that hematological and hemostatic abnormalities are associated with splenomegaly, hypersplenism and portal hypertension. Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000500332Revista Brasileira de Hematologia e Hemoterapia v.35 n.5 2013reponame:Revista brasileira de hematologia e hemoterapia (Online)instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)instacron:ABHHTC10.5581/1516-8484.20130098info:eu-repo/semantics/openAccessLeite,Luiz Arthur CalheirosDomingues,Ana Lucia CoutinhoLopes,Edmundo PessoaFerreira,Rita de Cassia dos SantosPimenta Filho,Adenor de AlmeidaFonseca,Caique Silveira Martins daSantos,Bianka Santana dosLima,Vera Lucia de Menezeseng2013-11-21T00:00:00Zoai:scielo:S1516-84842013000500332Revistahttp://www.rbhh.org/pt/archivo/https://old.scielo.br/oai/scielo-oai.phpsbhh@terra.com.br||secretaria@rbhh.org1806-08701516-8484opendoar:2013-11-21T00:00Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)false
dc.title.none.fl_str_mv Relationship between splenomegaly and hematologic findings in patients with hepatosplenic schistosomiasis
title Relationship between splenomegaly and hematologic findings in patients with hepatosplenic schistosomiasis
spellingShingle Relationship between splenomegaly and hematologic findings in patients with hepatosplenic schistosomiasis
Leite,Luiz Arthur Calheiros
Schistosomiasis mansoni
Schistosomiasis
Splenomegaly
Hypersplenism
Thrombocytopenia
title_short Relationship between splenomegaly and hematologic findings in patients with hepatosplenic schistosomiasis
title_full Relationship between splenomegaly and hematologic findings in patients with hepatosplenic schistosomiasis
title_fullStr Relationship between splenomegaly and hematologic findings in patients with hepatosplenic schistosomiasis
title_full_unstemmed Relationship between splenomegaly and hematologic findings in patients with hepatosplenic schistosomiasis
title_sort Relationship between splenomegaly and hematologic findings in patients with hepatosplenic schistosomiasis
author Leite,Luiz Arthur Calheiros
author_facet Leite,Luiz Arthur Calheiros
Domingues,Ana Lucia Coutinho
Lopes,Edmundo Pessoa
Ferreira,Rita de Cassia dos Santos
Pimenta Filho,Adenor de Almeida
Fonseca,Caique Silveira Martins da
Santos,Bianka Santana dos
Lima,Vera Lucia de Menezes
author_role author
author2 Domingues,Ana Lucia Coutinho
Lopes,Edmundo Pessoa
Ferreira,Rita de Cassia dos Santos
Pimenta Filho,Adenor de Almeida
Fonseca,Caique Silveira Martins da
Santos,Bianka Santana dos
Lima,Vera Lucia de Menezes
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Leite,Luiz Arthur Calheiros
Domingues,Ana Lucia Coutinho
Lopes,Edmundo Pessoa
Ferreira,Rita de Cassia dos Santos
Pimenta Filho,Adenor de Almeida
Fonseca,Caique Silveira Martins da
Santos,Bianka Santana dos
Lima,Vera Lucia de Menezes
dc.subject.por.fl_str_mv Schistosomiasis mansoni
Schistosomiasis
Splenomegaly
Hypersplenism
Thrombocytopenia
topic Schistosomiasis mansoni
Schistosomiasis
Splenomegaly
Hypersplenism
Thrombocytopenia
description BACKGROUND Schistosomiasis is a tropical disease. Patients who develop hepatosplenic schistosomiasis have clinical findings including periportal fibrosis, portal hypertension, cytopenia, splenomegaly and gastrointestinal hemorrhage. OBJECTIVE The aim of this study was to analyze the hemostatic and hematologic findings of patients with schistosomiasis and correlate these to the size of the spleen. METHODS Fifty-five adults with hepatosplenic schistosomiasis and 30 healthy subjects were selected through a history of contact with contaminated water, physical examination and ultrasound characteristics such as periportal fibrosis and splenomegaly in the Gastroenterology Service of the Universidade Federal de Pernambuco. Blood samples were collected to determine liver function, blood counts, prothrombin (international normalized ratio), partial thromboplastin time and fibrinogen and D-Dimer levels using the Pentra 120 hematological analyzer (HORIBA/ABX), Density Plus (test photo-optical Trinity Biotech, Ireland) and COBAS analyzer 6000 (Roche). Furthermore, the longitudinal size of the spleen was measured by ultrasound (Acuson X analyzer 150, Siemens). The Student t-test, the Fisher test and Pearson's correlation were used to analyze the results with statistical significance being set for a p-value < 0.05. RESULTS The mean age was higher for the Study Group than for the Control Group (54 ± 13.9 vs. 38 ± 12.7 years). The average longitudinal diameter of the spleen was 16.9 cm (Range: 12.3-26.3 cm). Anemia is a common finding in patients with schistosomiasis (36.3%). The mean platelet and leukocyte counts of patients were lower than for the Control Group (p-value < 0.001). Moreover, the international normalized ratio (1.42 vs. 1.04), partial thromboplastin time (37.9 vs. 30.5 seconds) and D-Dimer concentration (393 vs. 86.5 ng/mL) were higher for the Study Group compared to the Control Group. CONCLUSION This study suggests that hematological and hemostatic abnormalities are associated with splenomegaly, hypersplenism and portal hypertension.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000500332
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000500332
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5581/1516-8484.20130098
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
dc.source.none.fl_str_mv Revista Brasileira de Hematologia e Hemoterapia v.35 n.5 2013
reponame:Revista brasileira de hematologia e hemoterapia (Online)
instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron:ABHHTC
instname_str Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
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institution ABHHTC
reponame_str Revista brasileira de hematologia e hemoterapia (Online)
collection Revista brasileira de hematologia e hemoterapia (Online)
repository.name.fl_str_mv Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
repository.mail.fl_str_mv sbhh@terra.com.br||secretaria@rbhh.org
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