Relationship between splenomegaly and hematologic findings in patients with hepatosplenic schistosomiasis
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista brasileira de hematologia e hemoterapia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000500332 |
Resumo: | BACKGROUND Schistosomiasis is a tropical disease. Patients who develop hepatosplenic schistosomiasis have clinical findings including periportal fibrosis, portal hypertension, cytopenia, splenomegaly and gastrointestinal hemorrhage. OBJECTIVE The aim of this study was to analyze the hemostatic and hematologic findings of patients with schistosomiasis and correlate these to the size of the spleen. METHODS Fifty-five adults with hepatosplenic schistosomiasis and 30 healthy subjects were selected through a history of contact with contaminated water, physical examination and ultrasound characteristics such as periportal fibrosis and splenomegaly in the Gastroenterology Service of the Universidade Federal de Pernambuco. Blood samples were collected to determine liver function, blood counts, prothrombin (international normalized ratio), partial thromboplastin time and fibrinogen and D-Dimer levels using the Pentra 120 hematological analyzer (HORIBA/ABX), Density Plus (test photo-optical Trinity Biotech, Ireland) and COBAS analyzer 6000 (Roche). Furthermore, the longitudinal size of the spleen was measured by ultrasound (Acuson X analyzer 150, Siemens). The Student t-test, the Fisher test and Pearson's correlation were used to analyze the results with statistical significance being set for a p-value < 0.05. RESULTS The mean age was higher for the Study Group than for the Control Group (54 ± 13.9 vs. 38 ± 12.7 years). The average longitudinal diameter of the spleen was 16.9 cm (Range: 12.3-26.3 cm). Anemia is a common finding in patients with schistosomiasis (36.3%). The mean platelet and leukocyte counts of patients were lower than for the Control Group (p-value < 0.001). Moreover, the international normalized ratio (1.42 vs. 1.04), partial thromboplastin time (37.9 vs. 30.5 seconds) and D-Dimer concentration (393 vs. 86.5 ng/mL) were higher for the Study Group compared to the Control Group. CONCLUSION This study suggests that hematological and hemostatic abnormalities are associated with splenomegaly, hypersplenism and portal hypertension. |
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Relationship between splenomegaly and hematologic findings in patients with hepatosplenic schistosomiasisSchistosomiasis mansoniSchistosomiasisSplenomegalyHypersplenismThrombocytopenia BACKGROUND Schistosomiasis is a tropical disease. Patients who develop hepatosplenic schistosomiasis have clinical findings including periportal fibrosis, portal hypertension, cytopenia, splenomegaly and gastrointestinal hemorrhage. OBJECTIVE The aim of this study was to analyze the hemostatic and hematologic findings of patients with schistosomiasis and correlate these to the size of the spleen. METHODS Fifty-five adults with hepatosplenic schistosomiasis and 30 healthy subjects were selected through a history of contact with contaminated water, physical examination and ultrasound characteristics such as periportal fibrosis and splenomegaly in the Gastroenterology Service of the Universidade Federal de Pernambuco. Blood samples were collected to determine liver function, blood counts, prothrombin (international normalized ratio), partial thromboplastin time and fibrinogen and D-Dimer levels using the Pentra 120 hematological analyzer (HORIBA/ABX), Density Plus (test photo-optical Trinity Biotech, Ireland) and COBAS analyzer 6000 (Roche). Furthermore, the longitudinal size of the spleen was measured by ultrasound (Acuson X analyzer 150, Siemens). The Student t-test, the Fisher test and Pearson's correlation were used to analyze the results with statistical significance being set for a p-value < 0.05. RESULTS The mean age was higher for the Study Group than for the Control Group (54 ± 13.9 vs. 38 ± 12.7 years). The average longitudinal diameter of the spleen was 16.9 cm (Range: 12.3-26.3 cm). Anemia is a common finding in patients with schistosomiasis (36.3%). The mean platelet and leukocyte counts of patients were lower than for the Control Group (p-value < 0.001). Moreover, the international normalized ratio (1.42 vs. 1.04), partial thromboplastin time (37.9 vs. 30.5 seconds) and D-Dimer concentration (393 vs. 86.5 ng/mL) were higher for the Study Group compared to the Control Group. CONCLUSION This study suggests that hematological and hemostatic abnormalities are associated with splenomegaly, hypersplenism and portal hypertension. Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000500332Revista Brasileira de Hematologia e Hemoterapia v.35 n.5 2013reponame:Revista brasileira de hematologia e hemoterapia (Online)instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)instacron:ABHHTC10.5581/1516-8484.20130098info:eu-repo/semantics/openAccessLeite,Luiz Arthur CalheirosDomingues,Ana Lucia CoutinhoLopes,Edmundo PessoaFerreira,Rita de Cassia dos SantosPimenta Filho,Adenor de AlmeidaFonseca,Caique Silveira Martins daSantos,Bianka Santana dosLima,Vera Lucia de Menezeseng2013-11-21T00:00:00Zoai:scielo:S1516-84842013000500332Revistahttp://www.rbhh.org/pt/archivo/https://old.scielo.br/oai/scielo-oai.phpsbhh@terra.com.br||secretaria@rbhh.org1806-08701516-8484opendoar:2013-11-21T00:00Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)false |
dc.title.none.fl_str_mv |
Relationship between splenomegaly and hematologic findings in patients with hepatosplenic schistosomiasis |
title |
Relationship between splenomegaly and hematologic findings in patients with hepatosplenic schistosomiasis |
spellingShingle |
Relationship between splenomegaly and hematologic findings in patients with hepatosplenic schistosomiasis Leite,Luiz Arthur Calheiros Schistosomiasis mansoni Schistosomiasis Splenomegaly Hypersplenism Thrombocytopenia |
title_short |
Relationship between splenomegaly and hematologic findings in patients with hepatosplenic schistosomiasis |
title_full |
Relationship between splenomegaly and hematologic findings in patients with hepatosplenic schistosomiasis |
title_fullStr |
Relationship between splenomegaly and hematologic findings in patients with hepatosplenic schistosomiasis |
title_full_unstemmed |
Relationship between splenomegaly and hematologic findings in patients with hepatosplenic schistosomiasis |
title_sort |
Relationship between splenomegaly and hematologic findings in patients with hepatosplenic schistosomiasis |
author |
Leite,Luiz Arthur Calheiros |
author_facet |
Leite,Luiz Arthur Calheiros Domingues,Ana Lucia Coutinho Lopes,Edmundo Pessoa Ferreira,Rita de Cassia dos Santos Pimenta Filho,Adenor de Almeida Fonseca,Caique Silveira Martins da Santos,Bianka Santana dos Lima,Vera Lucia de Menezes |
author_role |
author |
author2 |
Domingues,Ana Lucia Coutinho Lopes,Edmundo Pessoa Ferreira,Rita de Cassia dos Santos Pimenta Filho,Adenor de Almeida Fonseca,Caique Silveira Martins da Santos,Bianka Santana dos Lima,Vera Lucia de Menezes |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Leite,Luiz Arthur Calheiros Domingues,Ana Lucia Coutinho Lopes,Edmundo Pessoa Ferreira,Rita de Cassia dos Santos Pimenta Filho,Adenor de Almeida Fonseca,Caique Silveira Martins da Santos,Bianka Santana dos Lima,Vera Lucia de Menezes |
dc.subject.por.fl_str_mv |
Schistosomiasis mansoni Schistosomiasis Splenomegaly Hypersplenism Thrombocytopenia |
topic |
Schistosomiasis mansoni Schistosomiasis Splenomegaly Hypersplenism Thrombocytopenia |
description |
BACKGROUND Schistosomiasis is a tropical disease. Patients who develop hepatosplenic schistosomiasis have clinical findings including periportal fibrosis, portal hypertension, cytopenia, splenomegaly and gastrointestinal hemorrhage. OBJECTIVE The aim of this study was to analyze the hemostatic and hematologic findings of patients with schistosomiasis and correlate these to the size of the spleen. METHODS Fifty-five adults with hepatosplenic schistosomiasis and 30 healthy subjects were selected through a history of contact with contaminated water, physical examination and ultrasound characteristics such as periportal fibrosis and splenomegaly in the Gastroenterology Service of the Universidade Federal de Pernambuco. Blood samples were collected to determine liver function, blood counts, prothrombin (international normalized ratio), partial thromboplastin time and fibrinogen and D-Dimer levels using the Pentra 120 hematological analyzer (HORIBA/ABX), Density Plus (test photo-optical Trinity Biotech, Ireland) and COBAS analyzer 6000 (Roche). Furthermore, the longitudinal size of the spleen was measured by ultrasound (Acuson X analyzer 150, Siemens). The Student t-test, the Fisher test and Pearson's correlation were used to analyze the results with statistical significance being set for a p-value < 0.05. RESULTS The mean age was higher for the Study Group than for the Control Group (54 ± 13.9 vs. 38 ± 12.7 years). The average longitudinal diameter of the spleen was 16.9 cm (Range: 12.3-26.3 cm). Anemia is a common finding in patients with schistosomiasis (36.3%). The mean platelet and leukocyte counts of patients were lower than for the Control Group (p-value < 0.001). Moreover, the international normalized ratio (1.42 vs. 1.04), partial thromboplastin time (37.9 vs. 30.5 seconds) and D-Dimer concentration (393 vs. 86.5 ng/mL) were higher for the Study Group compared to the Control Group. CONCLUSION This study suggests that hematological and hemostatic abnormalities are associated with splenomegaly, hypersplenism and portal hypertension. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000500332 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000500332 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5581/1516-8484.20130098 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular |
publisher.none.fl_str_mv |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular |
dc.source.none.fl_str_mv |
Revista Brasileira de Hematologia e Hemoterapia v.35 n.5 2013 reponame:Revista brasileira de hematologia e hemoterapia (Online) instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) instacron:ABHHTC |
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Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) |
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ABHHTC |
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ABHHTC |
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Revista brasileira de hematologia e hemoterapia (Online) |
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Revista brasileira de hematologia e hemoterapia (Online) |
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Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) |
repository.mail.fl_str_mv |
sbhh@terra.com.br||secretaria@rbhh.org |
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1754213112000544768 |