Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Revista brasileira de hematologia e hemoterapia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000100065 |
Resumo: | Long-term survivors of hematopoietic stem cell transplantation are recognized as a risk group for malignization. Malignant oral neoplasms are increasingly being reported in the literature as a consequence of lesions of chronic graft-versus-host disease, and prolonged multidrug treatment to control its manifestations. This report describes a 43-year-old patient who, after allogeneic bone marrow transplantation, developed an oral squamous cell carcinoma secondary to the use of azathioprine, cyclosporine, prednisone, and tacrolimus, associated with multiorgan chronic graft-versus-host disease involving the oral mucosa, skin, eyes, and liver. This report aims to discuss the possible role of immunosuppressant therapy for chronic graft-versus-host disease on the development of oral squamous cell carcinoma, and the relevance of a close oral follow-up of patients to detect dysplastic or malignant alterations at an early stage. |
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Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host diseaseMouth neoplasmsBone marrow transplantationLeukemiaMyeloidGraft-versus-host diseaseLong-term survivors of hematopoietic stem cell transplantation are recognized as a risk group for malignization. Malignant oral neoplasms are increasingly being reported in the literature as a consequence of lesions of chronic graft-versus-host disease, and prolonged multidrug treatment to control its manifestations. This report describes a 43-year-old patient who, after allogeneic bone marrow transplantation, developed an oral squamous cell carcinoma secondary to the use of azathioprine, cyclosporine, prednisone, and tacrolimus, associated with multiorgan chronic graft-versus-host disease involving the oral mucosa, skin, eyes, and liver. This report aims to discuss the possible role of immunosuppressant therapy for chronic graft-versus-host disease on the development of oral squamous cell carcinoma, and the relevance of a close oral follow-up of patients to detect dysplastic or malignant alterations at an early stage.Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular2014-02-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000100065Revista Brasileira de Hematologia e Hemoterapia v.36 n.1 2014reponame:Revista brasileira de hematologia e hemoterapia (Online)instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)instacron:ABHHTC10.5581/1516-8484.20140016info:eu-repo/semantics/openAccessAraujo,Renata Lins Fuentes deLyko,Karine de FatimaFunke,Vaneuza Araujo MoreiraTorres-Pereira,Cassius Carvalhoeng2014-03-07T00:00:00Zoai:scielo:S1516-84842014000100065Revistahttp://www.rbhh.org/pt/archivo/https://old.scielo.br/oai/scielo-oai.phpsbhh@terra.com.br||secretaria@rbhh.org1806-08701516-8484opendoar:2014-03-07T00:00Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)false |
dc.title.none.fl_str_mv |
Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease |
title |
Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease |
spellingShingle |
Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease Araujo,Renata Lins Fuentes de Mouth neoplasms Bone marrow transplantation Leukemia Myeloid Graft-versus-host disease |
title_short |
Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease |
title_full |
Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease |
title_fullStr |
Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease |
title_full_unstemmed |
Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease |
title_sort |
Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease |
author |
Araujo,Renata Lins Fuentes de |
author_facet |
Araujo,Renata Lins Fuentes de Lyko,Karine de Fatima Funke,Vaneuza Araujo Moreira Torres-Pereira,Cassius Carvalho |
author_role |
author |
author2 |
Lyko,Karine de Fatima Funke,Vaneuza Araujo Moreira Torres-Pereira,Cassius Carvalho |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Araujo,Renata Lins Fuentes de Lyko,Karine de Fatima Funke,Vaneuza Araujo Moreira Torres-Pereira,Cassius Carvalho |
dc.subject.por.fl_str_mv |
Mouth neoplasms Bone marrow transplantation Leukemia Myeloid Graft-versus-host disease |
topic |
Mouth neoplasms Bone marrow transplantation Leukemia Myeloid Graft-versus-host disease |
description |
Long-term survivors of hematopoietic stem cell transplantation are recognized as a risk group for malignization. Malignant oral neoplasms are increasingly being reported in the literature as a consequence of lesions of chronic graft-versus-host disease, and prolonged multidrug treatment to control its manifestations. This report describes a 43-year-old patient who, after allogeneic bone marrow transplantation, developed an oral squamous cell carcinoma secondary to the use of azathioprine, cyclosporine, prednisone, and tacrolimus, associated with multiorgan chronic graft-versus-host disease involving the oral mucosa, skin, eyes, and liver. This report aims to discuss the possible role of immunosuppressant therapy for chronic graft-versus-host disease on the development of oral squamous cell carcinoma, and the relevance of a close oral follow-up of patients to detect dysplastic or malignant alterations at an early stage. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000100065 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000100065 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5581/1516-8484.20140016 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular |
publisher.none.fl_str_mv |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular |
dc.source.none.fl_str_mv |
Revista Brasileira de Hematologia e Hemoterapia v.36 n.1 2014 reponame:Revista brasileira de hematologia e hemoterapia (Online) instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) instacron:ABHHTC |
instname_str |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) |
instacron_str |
ABHHTC |
institution |
ABHHTC |
reponame_str |
Revista brasileira de hematologia e hemoterapia (Online) |
collection |
Revista brasileira de hematologia e hemoterapia (Online) |
repository.name.fl_str_mv |
Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) |
repository.mail.fl_str_mv |
sbhh@terra.com.br||secretaria@rbhh.org |
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1754213112049827840 |