Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease

Detalhes bibliográficos
Autor(a) principal: Araujo,Renata Lins Fuentes de
Data de Publicação: 2014
Outros Autores: Lyko,Karine de Fatima, Funke,Vaneuza Araujo Moreira, Torres-Pereira,Cassius Carvalho
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Revista brasileira de hematologia e hemoterapia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000100065
Resumo: Long-term survivors of hematopoietic stem cell transplantation are recognized as a risk group for malignization. Malignant oral neoplasms are increasingly being reported in the literature as a consequence of lesions of chronic graft-versus-host disease, and prolonged multidrug treatment to control its manifestations. This report describes a 43-year-old patient who, after allogeneic bone marrow transplantation, developed an oral squamous cell carcinoma secondary to the use of azathioprine, cyclosporine, prednisone, and tacrolimus, associated with multiorgan chronic graft-versus-host disease involving the oral mucosa, skin, eyes, and liver. This report aims to discuss the possible role of immunosuppressant therapy for chronic graft-versus-host disease on the development of oral squamous cell carcinoma, and the relevance of a close oral follow-up of patients to detect dysplastic or malignant alterations at an early stage.
id ABHHTC-1_be33edc25fd547e4a5091bbbfc99d063
oai_identifier_str oai:scielo:S1516-84842014000100065
network_acronym_str ABHHTC-1
network_name_str Revista brasileira de hematologia e hemoterapia (Online)
repository_id_str
spelling Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host diseaseMouth neoplasmsBone marrow transplantationLeukemiaMyeloidGraft-versus-host diseaseLong-term survivors of hematopoietic stem cell transplantation are recognized as a risk group for malignization. Malignant oral neoplasms are increasingly being reported in the literature as a consequence of lesions of chronic graft-versus-host disease, and prolonged multidrug treatment to control its manifestations. This report describes a 43-year-old patient who, after allogeneic bone marrow transplantation, developed an oral squamous cell carcinoma secondary to the use of azathioprine, cyclosporine, prednisone, and tacrolimus, associated with multiorgan chronic graft-versus-host disease involving the oral mucosa, skin, eyes, and liver. This report aims to discuss the possible role of immunosuppressant therapy for chronic graft-versus-host disease on the development of oral squamous cell carcinoma, and the relevance of a close oral follow-up of patients to detect dysplastic or malignant alterations at an early stage.Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular2014-02-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000100065Revista Brasileira de Hematologia e Hemoterapia v.36 n.1 2014reponame:Revista brasileira de hematologia e hemoterapia (Online)instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)instacron:ABHHTC10.5581/1516-8484.20140016info:eu-repo/semantics/openAccessAraujo,Renata Lins Fuentes deLyko,Karine de FatimaFunke,Vaneuza Araujo MoreiraTorres-Pereira,Cassius Carvalhoeng2014-03-07T00:00:00Zoai:scielo:S1516-84842014000100065Revistahttp://www.rbhh.org/pt/archivo/https://old.scielo.br/oai/scielo-oai.phpsbhh@terra.com.br||secretaria@rbhh.org1806-08701516-8484opendoar:2014-03-07T00:00Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)false
dc.title.none.fl_str_mv Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease
title Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease
spellingShingle Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease
Araujo,Renata Lins Fuentes de
Mouth neoplasms
Bone marrow transplantation
Leukemia
Myeloid
Graft-versus-host disease
title_short Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease
title_full Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease
title_fullStr Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease
title_full_unstemmed Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease
title_sort Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease
author Araujo,Renata Lins Fuentes de
author_facet Araujo,Renata Lins Fuentes de
Lyko,Karine de Fatima
Funke,Vaneuza Araujo Moreira
Torres-Pereira,Cassius Carvalho
author_role author
author2 Lyko,Karine de Fatima
Funke,Vaneuza Araujo Moreira
Torres-Pereira,Cassius Carvalho
author2_role author
author
author
dc.contributor.author.fl_str_mv Araujo,Renata Lins Fuentes de
Lyko,Karine de Fatima
Funke,Vaneuza Araujo Moreira
Torres-Pereira,Cassius Carvalho
dc.subject.por.fl_str_mv Mouth neoplasms
Bone marrow transplantation
Leukemia
Myeloid
Graft-versus-host disease
topic Mouth neoplasms
Bone marrow transplantation
Leukemia
Myeloid
Graft-versus-host disease
description Long-term survivors of hematopoietic stem cell transplantation are recognized as a risk group for malignization. Malignant oral neoplasms are increasingly being reported in the literature as a consequence of lesions of chronic graft-versus-host disease, and prolonged multidrug treatment to control its manifestations. This report describes a 43-year-old patient who, after allogeneic bone marrow transplantation, developed an oral squamous cell carcinoma secondary to the use of azathioprine, cyclosporine, prednisone, and tacrolimus, associated with multiorgan chronic graft-versus-host disease involving the oral mucosa, skin, eyes, and liver. This report aims to discuss the possible role of immunosuppressant therapy for chronic graft-versus-host disease on the development of oral squamous cell carcinoma, and the relevance of a close oral follow-up of patients to detect dysplastic or malignant alterations at an early stage.
publishDate 2014
dc.date.none.fl_str_mv 2014-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000100065
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000100065
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5581/1516-8484.20140016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
dc.source.none.fl_str_mv Revista Brasileira de Hematologia e Hemoterapia v.36 n.1 2014
reponame:Revista brasileira de hematologia e hemoterapia (Online)
instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron:ABHHTC
instname_str Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron_str ABHHTC
institution ABHHTC
reponame_str Revista brasileira de hematologia e hemoterapia (Online)
collection Revista brasileira de hematologia e hemoterapia (Online)
repository.name.fl_str_mv Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
repository.mail.fl_str_mv sbhh@terra.com.br||secretaria@rbhh.org
_version_ 1754213112049827840