Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients

Detalhes bibliográficos
Autor(a) principal: Dinardo,Carla Luana
Data de Publicação: 2013
Outros Autores: Ito,Glaucia Munemasa, Sampaio,Luciana Ribeiro, Mendrone Junior,Alfredo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista brasileira de hematologia e hemoterapia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000600414
Resumo: Background: The inflammatory background of patients influences the process of alloimmunization against red blood cell antigens. Proof of this statement to clinical practice is still lacking. Objective: The aim of this study was to verify whether factors related to disease severity and inflammatory status of cancer patients can predict alloimmunization. Methods: This was a case-control study in which alloimmunized oncologic patients treated between 2009 and 2012 were compared with a non-alloimmunized control group regarding the severity of the disease (metastasis/performance status/body mass index) and C-reactive protein levels. Results: The groups did not differ significantly in terms of C-reactive protein, Eastern Cooperative Oncology Group (ECOG)/Karnofsky performance status, presence of metastasis and body mass index. Conclusion: It is not possible to predict alloimmunization in cancer patients based on severity of illness and inflammatory markers. Strategies of screening patients by phenotyping blood based on these criteria are not justified.
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spelling Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patientsOxidative stressBeta-thalassemiaLipid peroxidationBeta-globinsThiobarbituric acid reactive substancesMutation Background: The inflammatory background of patients influences the process of alloimmunization against red blood cell antigens. Proof of this statement to clinical practice is still lacking. Objective: The aim of this study was to verify whether factors related to disease severity and inflammatory status of cancer patients can predict alloimmunization. Methods: This was a case-control study in which alloimmunized oncologic patients treated between 2009 and 2012 were compared with a non-alloimmunized control group regarding the severity of the disease (metastasis/performance status/body mass index) and C-reactive protein levels. Results: The groups did not differ significantly in terms of C-reactive protein, Eastern Cooperative Oncology Group (ECOG)/Karnofsky performance status, presence of metastasis and body mass index. Conclusion: It is not possible to predict alloimmunization in cancer patients based on severity of illness and inflammatory markers. Strategies of screening patients by phenotyping blood based on these criteria are not justified. Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular2013-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000600414Revista Brasileira de Hematologia e Hemoterapia v.35 n.6 2013reponame:Revista brasileira de hematologia e hemoterapia (Online)instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)instacron:ABHHTC10.5581/1516-8484.20130123info:eu-repo/semantics/openAccessDinardo,Carla LuanaIto,Glaucia MunemasaSampaio,Luciana RibeiroMendrone Junior,Alfredoeng2014-01-29T00:00:00Zoai:scielo:S1516-84842013000600414Revistahttp://www.rbhh.org/pt/archivo/https://old.scielo.br/oai/scielo-oai.phpsbhh@terra.com.br||secretaria@rbhh.org1806-08701516-8484opendoar:2014-01-29T00:00Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)false
dc.title.none.fl_str_mv Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients
title Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients
spellingShingle Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients
Dinardo,Carla Luana
Oxidative stress
Beta-thalassemia
Lipid peroxidation
Beta-globins
Thiobarbituric acid reactive substances
Mutation
title_short Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients
title_full Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients
title_fullStr Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients
title_full_unstemmed Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients
title_sort Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients
author Dinardo,Carla Luana
author_facet Dinardo,Carla Luana
Ito,Glaucia Munemasa
Sampaio,Luciana Ribeiro
Mendrone Junior,Alfredo
author_role author
author2 Ito,Glaucia Munemasa
Sampaio,Luciana Ribeiro
Mendrone Junior,Alfredo
author2_role author
author
author
dc.contributor.author.fl_str_mv Dinardo,Carla Luana
Ito,Glaucia Munemasa
Sampaio,Luciana Ribeiro
Mendrone Junior,Alfredo
dc.subject.por.fl_str_mv Oxidative stress
Beta-thalassemia
Lipid peroxidation
Beta-globins
Thiobarbituric acid reactive substances
Mutation
topic Oxidative stress
Beta-thalassemia
Lipid peroxidation
Beta-globins
Thiobarbituric acid reactive substances
Mutation
description Background: The inflammatory background of patients influences the process of alloimmunization against red blood cell antigens. Proof of this statement to clinical practice is still lacking. Objective: The aim of this study was to verify whether factors related to disease severity and inflammatory status of cancer patients can predict alloimmunization. Methods: This was a case-control study in which alloimmunized oncologic patients treated between 2009 and 2012 were compared with a non-alloimmunized control group regarding the severity of the disease (metastasis/performance status/body mass index) and C-reactive protein levels. Results: The groups did not differ significantly in terms of C-reactive protein, Eastern Cooperative Oncology Group (ECOG)/Karnofsky performance status, presence of metastasis and body mass index. Conclusion: It is not possible to predict alloimmunization in cancer patients based on severity of illness and inflammatory markers. Strategies of screening patients by phenotyping blood based on these criteria are not justified.
publishDate 2013
dc.date.none.fl_str_mv 2013-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000600414
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000600414
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5581/1516-8484.20130123
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
dc.source.none.fl_str_mv Revista Brasileira de Hematologia e Hemoterapia v.35 n.6 2013
reponame:Revista brasileira de hematologia e hemoterapia (Online)
instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron:ABHHTC
instname_str Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron_str ABHHTC
institution ABHHTC
reponame_str Revista brasileira de hematologia e hemoterapia (Online)
collection Revista brasileira de hematologia e hemoterapia (Online)
repository.name.fl_str_mv Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
repository.mail.fl_str_mv sbhh@terra.com.br||secretaria@rbhh.org
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