Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista brasileira de hematologia e hemoterapia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000600414 |
Resumo: | Background: The inflammatory background of patients influences the process of alloimmunization against red blood cell antigens. Proof of this statement to clinical practice is still lacking. Objective: The aim of this study was to verify whether factors related to disease severity and inflammatory status of cancer patients can predict alloimmunization. Methods: This was a case-control study in which alloimmunized oncologic patients treated between 2009 and 2012 were compared with a non-alloimmunized control group regarding the severity of the disease (metastasis/performance status/body mass index) and C-reactive protein levels. Results: The groups did not differ significantly in terms of C-reactive protein, Eastern Cooperative Oncology Group (ECOG)/Karnofsky performance status, presence of metastasis and body mass index. Conclusion: It is not possible to predict alloimmunization in cancer patients based on severity of illness and inflammatory markers. Strategies of screening patients by phenotyping blood based on these criteria are not justified. |
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Revista brasileira de hematologia e hemoterapia (Online) |
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Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patientsOxidative stressBeta-thalassemiaLipid peroxidationBeta-globinsThiobarbituric acid reactive substancesMutation Background: The inflammatory background of patients influences the process of alloimmunization against red blood cell antigens. Proof of this statement to clinical practice is still lacking. Objective: The aim of this study was to verify whether factors related to disease severity and inflammatory status of cancer patients can predict alloimmunization. Methods: This was a case-control study in which alloimmunized oncologic patients treated between 2009 and 2012 were compared with a non-alloimmunized control group regarding the severity of the disease (metastasis/performance status/body mass index) and C-reactive protein levels. Results: The groups did not differ significantly in terms of C-reactive protein, Eastern Cooperative Oncology Group (ECOG)/Karnofsky performance status, presence of metastasis and body mass index. Conclusion: It is not possible to predict alloimmunization in cancer patients based on severity of illness and inflammatory markers. Strategies of screening patients by phenotyping blood based on these criteria are not justified. Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular2013-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000600414Revista Brasileira de Hematologia e Hemoterapia v.35 n.6 2013reponame:Revista brasileira de hematologia e hemoterapia (Online)instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)instacron:ABHHTC10.5581/1516-8484.20130123info:eu-repo/semantics/openAccessDinardo,Carla LuanaIto,Glaucia MunemasaSampaio,Luciana RibeiroMendrone Junior,Alfredoeng2014-01-29T00:00:00Zoai:scielo:S1516-84842013000600414Revistahttp://www.rbhh.org/pt/archivo/https://old.scielo.br/oai/scielo-oai.phpsbhh@terra.com.br||secretaria@rbhh.org1806-08701516-8484opendoar:2014-01-29T00:00Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)false |
dc.title.none.fl_str_mv |
Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients |
title |
Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients |
spellingShingle |
Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients Dinardo,Carla Luana Oxidative stress Beta-thalassemia Lipid peroxidation Beta-globins Thiobarbituric acid reactive substances Mutation |
title_short |
Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients |
title_full |
Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients |
title_fullStr |
Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients |
title_full_unstemmed |
Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients |
title_sort |
Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients |
author |
Dinardo,Carla Luana |
author_facet |
Dinardo,Carla Luana Ito,Glaucia Munemasa Sampaio,Luciana Ribeiro Mendrone Junior,Alfredo |
author_role |
author |
author2 |
Ito,Glaucia Munemasa Sampaio,Luciana Ribeiro Mendrone Junior,Alfredo |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Dinardo,Carla Luana Ito,Glaucia Munemasa Sampaio,Luciana Ribeiro Mendrone Junior,Alfredo |
dc.subject.por.fl_str_mv |
Oxidative stress Beta-thalassemia Lipid peroxidation Beta-globins Thiobarbituric acid reactive substances Mutation |
topic |
Oxidative stress Beta-thalassemia Lipid peroxidation Beta-globins Thiobarbituric acid reactive substances Mutation |
description |
Background: The inflammatory background of patients influences the process of alloimmunization against red blood cell antigens. Proof of this statement to clinical practice is still lacking. Objective: The aim of this study was to verify whether factors related to disease severity and inflammatory status of cancer patients can predict alloimmunization. Methods: This was a case-control study in which alloimmunized oncologic patients treated between 2009 and 2012 were compared with a non-alloimmunized control group regarding the severity of the disease (metastasis/performance status/body mass index) and C-reactive protein levels. Results: The groups did not differ significantly in terms of C-reactive protein, Eastern Cooperative Oncology Group (ECOG)/Karnofsky performance status, presence of metastasis and body mass index. Conclusion: It is not possible to predict alloimmunization in cancer patients based on severity of illness and inflammatory markers. Strategies of screening patients by phenotyping blood based on these criteria are not justified. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000600414 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000600414 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5581/1516-8484.20130123 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular |
publisher.none.fl_str_mv |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular |
dc.source.none.fl_str_mv |
Revista Brasileira de Hematologia e Hemoterapia v.35 n.6 2013 reponame:Revista brasileira de hematologia e hemoterapia (Online) instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) instacron:ABHHTC |
instname_str |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) |
instacron_str |
ABHHTC |
institution |
ABHHTC |
reponame_str |
Revista brasileira de hematologia e hemoterapia (Online) |
collection |
Revista brasileira de hematologia e hemoterapia (Online) |
repository.name.fl_str_mv |
Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) |
repository.mail.fl_str_mv |
sbhh@terra.com.br||secretaria@rbhh.org |
_version_ |
1754213112025710592 |