Splenic marginal zone lymphoma: a literature review of diagnostic and therapeutic challenges

Detalhes bibliográficos
Autor(a) principal: Santos,Tayse Silva dos
Data de Publicação: 2017
Outros Autores: Tavares,Renato Sampaio, Farias,Danielle Leão Cordeiro de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista brasileira de hematologia e hemoterapia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842017000200146
Resumo: ABSTRACT Splenic marginal zone lymphoma (SMZL) is a low-grade B-cell non-Hodgkin's lymphoma characterized by massive splenomegaly, moderate lymphocytosis with or without villous lymphocytes, rare involvement of peripheral lymph nodes and indolent clinical course. As a rare disease, with no randomized prospective trials, there is no standard of care for SMZL so far. Splenectomy has been done for many years as an attempt to control disease, but nowadays it has not been encouraged as first line because of new advances in therapy as rituximab, that are as effective with minimal toxicity. Facing these controversies, this review highlights advances in the literature regarding diagnosis, prognostic factors, treatment indications and therapeutic options.
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spelling Splenic marginal zone lymphoma: a literature review of diagnostic and therapeutic challengesLymphoma, non-HodgkinSplenic marginal zone lymphomaSplenic lymphomaIndolent lymphomaRituximabABSTRACT Splenic marginal zone lymphoma (SMZL) is a low-grade B-cell non-Hodgkin's lymphoma characterized by massive splenomegaly, moderate lymphocytosis with or without villous lymphocytes, rare involvement of peripheral lymph nodes and indolent clinical course. As a rare disease, with no randomized prospective trials, there is no standard of care for SMZL so far. Splenectomy has been done for many years as an attempt to control disease, but nowadays it has not been encouraged as first line because of new advances in therapy as rituximab, that are as effective with minimal toxicity. Facing these controversies, this review highlights advances in the literature regarding diagnosis, prognostic factors, treatment indications and therapeutic options.Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular2017-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842017000200146Revista Brasileira de Hematologia e Hemoterapia v.39 n.2 2017reponame:Revista brasileira de hematologia e hemoterapia (Online)instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)instacron:ABHHTC10.1016/j.bjhh.2016.09.014info:eu-repo/semantics/openAccessSantos,Tayse Silva dosTavares,Renato SampaioFarias,Danielle Leão Cordeiro deeng2017-06-29T00:00:00Zoai:scielo:S1516-84842017000200146Revistahttp://www.rbhh.org/pt/archivo/https://old.scielo.br/oai/scielo-oai.phpsbhh@terra.com.br||secretaria@rbhh.org1806-08701516-8484opendoar:2017-06-29T00:00Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)false
dc.title.none.fl_str_mv Splenic marginal zone lymphoma: a literature review of diagnostic and therapeutic challenges
title Splenic marginal zone lymphoma: a literature review of diagnostic and therapeutic challenges
spellingShingle Splenic marginal zone lymphoma: a literature review of diagnostic and therapeutic challenges
Santos,Tayse Silva dos
Lymphoma, non-Hodgkin
Splenic marginal zone lymphoma
Splenic lymphoma
Indolent lymphoma
Rituximab
title_short Splenic marginal zone lymphoma: a literature review of diagnostic and therapeutic challenges
title_full Splenic marginal zone lymphoma: a literature review of diagnostic and therapeutic challenges
title_fullStr Splenic marginal zone lymphoma: a literature review of diagnostic and therapeutic challenges
title_full_unstemmed Splenic marginal zone lymphoma: a literature review of diagnostic and therapeutic challenges
title_sort Splenic marginal zone lymphoma: a literature review of diagnostic and therapeutic challenges
author Santos,Tayse Silva dos
author_facet Santos,Tayse Silva dos
Tavares,Renato Sampaio
Farias,Danielle Leão Cordeiro de
author_role author
author2 Tavares,Renato Sampaio
Farias,Danielle Leão Cordeiro de
author2_role author
author
dc.contributor.author.fl_str_mv Santos,Tayse Silva dos
Tavares,Renato Sampaio
Farias,Danielle Leão Cordeiro de
dc.subject.por.fl_str_mv Lymphoma, non-Hodgkin
Splenic marginal zone lymphoma
Splenic lymphoma
Indolent lymphoma
Rituximab
topic Lymphoma, non-Hodgkin
Splenic marginal zone lymphoma
Splenic lymphoma
Indolent lymphoma
Rituximab
description ABSTRACT Splenic marginal zone lymphoma (SMZL) is a low-grade B-cell non-Hodgkin's lymphoma characterized by massive splenomegaly, moderate lymphocytosis with or without villous lymphocytes, rare involvement of peripheral lymph nodes and indolent clinical course. As a rare disease, with no randomized prospective trials, there is no standard of care for SMZL so far. Splenectomy has been done for many years as an attempt to control disease, but nowadays it has not been encouraged as first line because of new advances in therapy as rituximab, that are as effective with minimal toxicity. Facing these controversies, this review highlights advances in the literature regarding diagnosis, prognostic factors, treatment indications and therapeutic options.
publishDate 2017
dc.date.none.fl_str_mv 2017-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842017000200146
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842017000200146
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjhh.2016.09.014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
dc.source.none.fl_str_mv Revista Brasileira de Hematologia e Hemoterapia v.39 n.2 2017
reponame:Revista brasileira de hematologia e hemoterapia (Online)
instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron:ABHHTC
instname_str Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron_str ABHHTC
institution ABHHTC
reponame_str Revista brasileira de hematologia e hemoterapia (Online)
collection Revista brasileira de hematologia e hemoterapia (Online)
repository.name.fl_str_mv Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
repository.mail.fl_str_mv sbhh@terra.com.br||secretaria@rbhh.org
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