Effect of solvents on the morphological characterization of enteric nanoparticles
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Materials research (São Carlos. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392009000400005 |
Resumo: | Size and external and internal morphologies of nanoparticles and microparticles are very important on the design of drug devices for controlled release. Random enteric copolymers such as poly (methacrylic acid-co-ethyl acrylate) and poly (methacrylic acid-co-methyl methacrylate) were used to produce nanoparticles, which contain a model drug and could be employed as drug carriers for proteins. The solvent effect on re-dispersion of such nanoparticles was studied by Scanning Electron Microscopy (SEM) and revealed not only differences in size, but also several shapes, depending on the chemical nature of the polymer matrix and the non-solvent used. Acrylate containing copolymers in acidic aqueous dispersions lead to spheroidal particles. However for the copolymer containing methyl methacrylate, spheroidal particles collapsed in a "grenade" type morphology and besides some cubic structures are also formed. Dynamic Light Scattering (DLS) studies of the re-dispersed nanoparticles showed the strong tendency to form agglomerates not only in acidic water but also in hexane and the presence of bimodal size distributions. |
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Effect of solvents on the morphological characterization of enteric nanoparticlesnanoparticles morphologyenteric copolymerssolvent effectagglomeratesSize and external and internal morphologies of nanoparticles and microparticles are very important on the design of drug devices for controlled release. Random enteric copolymers such as poly (methacrylic acid-co-ethyl acrylate) and poly (methacrylic acid-co-methyl methacrylate) were used to produce nanoparticles, which contain a model drug and could be employed as drug carriers for proteins. The solvent effect on re-dispersion of such nanoparticles was studied by Scanning Electron Microscopy (SEM) and revealed not only differences in size, but also several shapes, depending on the chemical nature of the polymer matrix and the non-solvent used. Acrylate containing copolymers in acidic aqueous dispersions lead to spheroidal particles. However for the copolymer containing methyl methacrylate, spheroidal particles collapsed in a "grenade" type morphology and besides some cubic structures are also formed. Dynamic Light Scattering (DLS) studies of the re-dispersed nanoparticles showed the strong tendency to form agglomerates not only in acidic water but also in hexane and the presence of bimodal size distributions.ABM, ABC, ABPol2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392009000400005Materials Research v.12 n.4 2009reponame:Materials research (São Carlos. Online)instname:Universidade Federal de São Carlos (UFSCAR)instacron:ABM ABC ABPOL10.1590/S1516-14392009000400005info:eu-repo/semantics/openAccessDupeyrón Martell,Danay RosaRieumont Briones,JacquesGonzález Hurtado,Mayradel Real López,AliciaCastaño Meneses,Víctor Manueleng2010-01-19T00:00:00Zoai:scielo:S1516-14392009000400005Revistahttp://www.scielo.br/mrPUBhttps://old.scielo.br/oai/scielo-oai.phpdedz@power.ufscar.br1980-53731516-1439opendoar:2010-01-19T00:00Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)false |
dc.title.none.fl_str_mv |
Effect of solvents on the morphological characterization of enteric nanoparticles |
title |
Effect of solvents on the morphological characterization of enteric nanoparticles |
spellingShingle |
Effect of solvents on the morphological characterization of enteric nanoparticles Dupeyrón Martell,Danay Rosa nanoparticles morphology enteric copolymers solvent effect agglomerates |
title_short |
Effect of solvents on the morphological characterization of enteric nanoparticles |
title_full |
Effect of solvents on the morphological characterization of enteric nanoparticles |
title_fullStr |
Effect of solvents on the morphological characterization of enteric nanoparticles |
title_full_unstemmed |
Effect of solvents on the morphological characterization of enteric nanoparticles |
title_sort |
Effect of solvents on the morphological characterization of enteric nanoparticles |
author |
Dupeyrón Martell,Danay Rosa |
author_facet |
Dupeyrón Martell,Danay Rosa Rieumont Briones,Jacques González Hurtado,Mayra del Real López,Alicia Castaño Meneses,Víctor Manuel |
author_role |
author |
author2 |
Rieumont Briones,Jacques González Hurtado,Mayra del Real López,Alicia Castaño Meneses,Víctor Manuel |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Dupeyrón Martell,Danay Rosa Rieumont Briones,Jacques González Hurtado,Mayra del Real López,Alicia Castaño Meneses,Víctor Manuel |
dc.subject.por.fl_str_mv |
nanoparticles morphology enteric copolymers solvent effect agglomerates |
topic |
nanoparticles morphology enteric copolymers solvent effect agglomerates |
description |
Size and external and internal morphologies of nanoparticles and microparticles are very important on the design of drug devices for controlled release. Random enteric copolymers such as poly (methacrylic acid-co-ethyl acrylate) and poly (methacrylic acid-co-methyl methacrylate) were used to produce nanoparticles, which contain a model drug and could be employed as drug carriers for proteins. The solvent effect on re-dispersion of such nanoparticles was studied by Scanning Electron Microscopy (SEM) and revealed not only differences in size, but also several shapes, depending on the chemical nature of the polymer matrix and the non-solvent used. Acrylate containing copolymers in acidic aqueous dispersions lead to spheroidal particles. However for the copolymer containing methyl methacrylate, spheroidal particles collapsed in a "grenade" type morphology and besides some cubic structures are also formed. Dynamic Light Scattering (DLS) studies of the re-dispersed nanoparticles showed the strong tendency to form agglomerates not only in acidic water but also in hexane and the presence of bimodal size distributions. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392009000400005 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392009000400005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-14392009000400005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
ABM, ABC, ABPol |
publisher.none.fl_str_mv |
ABM, ABC, ABPol |
dc.source.none.fl_str_mv |
Materials Research v.12 n.4 2009 reponame:Materials research (São Carlos. Online) instname:Universidade Federal de São Carlos (UFSCAR) instacron:ABM ABC ABPOL |
instname_str |
Universidade Federal de São Carlos (UFSCAR) |
instacron_str |
ABM ABC ABPOL |
institution |
ABM ABC ABPOL |
reponame_str |
Materials research (São Carlos. Online) |
collection |
Materials research (São Carlos. Online) |
repository.name.fl_str_mv |
Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR) |
repository.mail.fl_str_mv |
dedz@power.ufscar.br |
_version_ |
1754212659318751232 |