Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva

Detalhes bibliográficos
Autor(a) principal: Holz,Juliana Pelisoli
Data de Publicação: 2018
Outros Autores: Bottene,Marcia Karpinski, Jahno,Vanusca Dalosto, Einloft,Sandra, Ligabue,Rosane
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Materials research (São Carlos. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392018000209102
Resumo: Menthol-loaded PLGA micro/nanospheres were synthesized using the multiple emulsion/solvent evaporation technique. Parameters such as stirring rate, external surfactant content, PLGA/menthol weight ratio, solvent evaporation and lyophilization time were evaluated as well as the degradation of micro/nanospheres in an artificial saliva medium. The menthol/PLGA micro/nanospheres thus obtained had a size distribution of between 217 nm and 13 µm and particles with spherical and dense morphology were evidenced by SEM micrographs. FTIR and TGA data showed an increase up to 60% of menthol incorporated in the micro/nanoparticles. The degradation of menthol-loaded PLGA micro/nanoparticles in artificial saliva significantly affected the particles morphology and appears to be an effective medium for releasing menthol.
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spelling Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Salivaemulsionmentholmicro/nanospheresPLGAMenthol-loaded PLGA micro/nanospheres were synthesized using the multiple emulsion/solvent evaporation technique. Parameters such as stirring rate, external surfactant content, PLGA/menthol weight ratio, solvent evaporation and lyophilization time were evaluated as well as the degradation of micro/nanospheres in an artificial saliva medium. The menthol/PLGA micro/nanospheres thus obtained had a size distribution of between 217 nm and 13 µm and particles with spherical and dense morphology were evidenced by SEM micrographs. FTIR and TGA data showed an increase up to 60% of menthol incorporated in the micro/nanoparticles. The degradation of menthol-loaded PLGA micro/nanoparticles in artificial saliva significantly affected the particles morphology and appears to be an effective medium for releasing menthol.ABM, ABC, ABPol2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392018000209102Materials Research v.21 n.2 2018reponame:Materials research (São Carlos. Online)instname:Universidade Federal de São Carlos (UFSCAR)instacron:ABM ABC ABPOL10.1590/1980-5373-mr-2017-0488info:eu-repo/semantics/openAccessHolz,Juliana PelisoliBottene,Marcia KarpinskiJahno,Vanusca DalostoEinloft,SandraLigabue,Rosaneeng2018-05-15T00:00:00Zoai:scielo:S1516-14392018000209102Revistahttp://www.scielo.br/mrPUBhttps://old.scielo.br/oai/scielo-oai.phpdedz@power.ufscar.br1980-53731516-1439opendoar:2018-05-15T00:00Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)false
dc.title.none.fl_str_mv Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva
title Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva
spellingShingle Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva
Holz,Juliana Pelisoli
emulsion
menthol
micro/nanospheres
PLGA
title_short Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva
title_full Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva
title_fullStr Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva
title_full_unstemmed Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva
title_sort Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva
author Holz,Juliana Pelisoli
author_facet Holz,Juliana Pelisoli
Bottene,Marcia Karpinski
Jahno,Vanusca Dalosto
Einloft,Sandra
Ligabue,Rosane
author_role author
author2 Bottene,Marcia Karpinski
Jahno,Vanusca Dalosto
Einloft,Sandra
Ligabue,Rosane
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Holz,Juliana Pelisoli
Bottene,Marcia Karpinski
Jahno,Vanusca Dalosto
Einloft,Sandra
Ligabue,Rosane
dc.subject.por.fl_str_mv emulsion
menthol
micro/nanospheres
PLGA
topic emulsion
menthol
micro/nanospheres
PLGA
description Menthol-loaded PLGA micro/nanospheres were synthesized using the multiple emulsion/solvent evaporation technique. Parameters such as stirring rate, external surfactant content, PLGA/menthol weight ratio, solvent evaporation and lyophilization time were evaluated as well as the degradation of micro/nanospheres in an artificial saliva medium. The menthol/PLGA micro/nanospheres thus obtained had a size distribution of between 217 nm and 13 µm and particles with spherical and dense morphology were evidenced by SEM micrographs. FTIR and TGA data showed an increase up to 60% of menthol incorporated in the micro/nanoparticles. The degradation of menthol-loaded PLGA micro/nanoparticles in artificial saliva significantly affected the particles morphology and appears to be an effective medium for releasing menthol.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392018000209102
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392018000209102
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1980-5373-mr-2017-0488
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv ABM, ABC, ABPol
publisher.none.fl_str_mv ABM, ABC, ABPol
dc.source.none.fl_str_mv Materials Research v.21 n.2 2018
reponame:Materials research (São Carlos. Online)
instname:Universidade Federal de São Carlos (UFSCAR)
instacron:ABM ABC ABPOL
instname_str Universidade Federal de São Carlos (UFSCAR)
instacron_str ABM ABC ABPOL
institution ABM ABC ABPOL
reponame_str Materials research (São Carlos. Online)
collection Materials research (São Carlos. Online)
repository.name.fl_str_mv Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)
repository.mail.fl_str_mv dedz@power.ufscar.br
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