Optimizing the Water-Oil Emulsification Process for Developing CPC Microspheres

Detalhes bibliográficos
Autor(a) principal: Renó,Caroline de Oliveira
Data de Publicação: 2016
Outros Autores: Motisuke,Mariana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Materials research (São Carlos. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392016000601388
Resumo: Spherical calcium phosphate cement carriers were synthesized by water/oil emulsion. A 23 factorial design was employed in order to optimize the size and form of the microspheres. Stirring speed, liquid-to-powder ratio and cement paste-to-oil ratio were varied in two different levels and the response variable was the microsphere's sphericity. The results showed that cement's setting reaction was responsible for stabilizing the microspheres within the oil phase resulting in a low crystalline hydroxyapatite. The sizes varied from 6.29 to 64.23 µm. From the factors studied, the stirring velocity and the interaction between the L/P ratio with the P/O ratio are the ones that are more effective in controlling microspheres' sphericity. The results suggest that the methodology studied may provide microspheres with appropriate properties to deliver cells and/or drugs without inducing inflammatory reactions.
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spelling Optimizing the Water-Oil Emulsification Process for Developing CPC Microspherescalcium phosphate cementmicrosphereswater/oil emulsionalpha- tricalcium phosphatefactorial designSpherical calcium phosphate cement carriers were synthesized by water/oil emulsion. A 23 factorial design was employed in order to optimize the size and form of the microspheres. Stirring speed, liquid-to-powder ratio and cement paste-to-oil ratio were varied in two different levels and the response variable was the microsphere's sphericity. The results showed that cement's setting reaction was responsible for stabilizing the microspheres within the oil phase resulting in a low crystalline hydroxyapatite. The sizes varied from 6.29 to 64.23 µm. From the factors studied, the stirring velocity and the interaction between the L/P ratio with the P/O ratio are the ones that are more effective in controlling microspheres' sphericity. The results suggest that the methodology studied may provide microspheres with appropriate properties to deliver cells and/or drugs without inducing inflammatory reactions.ABM, ABC, ABPol2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392016000601388Materials Research v.19 n.6 2016reponame:Materials research (São Carlos. Online)instname:Universidade Federal de São Carlos (UFSCAR)instacron:ABM ABC ABPOL10.1590/1980-5373-mr-2016-0189info:eu-repo/semantics/openAccessRenó,Caroline de OliveiraMotisuke,Marianaeng2016-12-20T00:00:00Zoai:scielo:S1516-14392016000601388Revistahttp://www.scielo.br/mrPUBhttps://old.scielo.br/oai/scielo-oai.phpdedz@power.ufscar.br1980-53731516-1439opendoar:2016-12-20T00:00Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)false
dc.title.none.fl_str_mv Optimizing the Water-Oil Emulsification Process for Developing CPC Microspheres
title Optimizing the Water-Oil Emulsification Process for Developing CPC Microspheres
spellingShingle Optimizing the Water-Oil Emulsification Process for Developing CPC Microspheres
Renó,Caroline de Oliveira
calcium phosphate cement
microspheres
water/oil emulsion
alpha- tricalcium phosphate
factorial design
title_short Optimizing the Water-Oil Emulsification Process for Developing CPC Microspheres
title_full Optimizing the Water-Oil Emulsification Process for Developing CPC Microspheres
title_fullStr Optimizing the Water-Oil Emulsification Process for Developing CPC Microspheres
title_full_unstemmed Optimizing the Water-Oil Emulsification Process for Developing CPC Microspheres
title_sort Optimizing the Water-Oil Emulsification Process for Developing CPC Microspheres
author Renó,Caroline de Oliveira
author_facet Renó,Caroline de Oliveira
Motisuke,Mariana
author_role author
author2 Motisuke,Mariana
author2_role author
dc.contributor.author.fl_str_mv Renó,Caroline de Oliveira
Motisuke,Mariana
dc.subject.por.fl_str_mv calcium phosphate cement
microspheres
water/oil emulsion
alpha- tricalcium phosphate
factorial design
topic calcium phosphate cement
microspheres
water/oil emulsion
alpha- tricalcium phosphate
factorial design
description Spherical calcium phosphate cement carriers were synthesized by water/oil emulsion. A 23 factorial design was employed in order to optimize the size and form of the microspheres. Stirring speed, liquid-to-powder ratio and cement paste-to-oil ratio were varied in two different levels and the response variable was the microsphere's sphericity. The results showed that cement's setting reaction was responsible for stabilizing the microspheres within the oil phase resulting in a low crystalline hydroxyapatite. The sizes varied from 6.29 to 64.23 µm. From the factors studied, the stirring velocity and the interaction between the L/P ratio with the P/O ratio are the ones that are more effective in controlling microspheres' sphericity. The results suggest that the methodology studied may provide microspheres with appropriate properties to deliver cells and/or drugs without inducing inflammatory reactions.
publishDate 2016
dc.date.none.fl_str_mv 2016-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392016000601388
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392016000601388
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1980-5373-mr-2016-0189
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv ABM, ABC, ABPol
publisher.none.fl_str_mv ABM, ABC, ABPol
dc.source.none.fl_str_mv Materials Research v.19 n.6 2016
reponame:Materials research (São Carlos. Online)
instname:Universidade Federal de São Carlos (UFSCAR)
instacron:ABM ABC ABPOL
instname_str Universidade Federal de São Carlos (UFSCAR)
instacron_str ABM ABC ABPOL
institution ABM ABC ABPOL
reponame_str Materials research (São Carlos. Online)
collection Materials research (São Carlos. Online)
repository.name.fl_str_mv Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)
repository.mail.fl_str_mv dedz@power.ufscar.br
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