In vitro degradation of Poly-L-co-D, L-lactic acid membranes

Detalhes bibliográficos
Autor(a) principal: Baraúna,Grazielle
Data de Publicação: 2013
Outros Autores: Coraça-Huber,Débora Cristina, Duek,Eliana Aparecida de Rezende
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Materials research (São Carlos. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392013000100028
Resumo: Poly-L-co-D.L-lactic (PLDLA) is a bioresorbable polymer whose properties have been studied for degradation sensitivity and its application in medicine. In this study, the potential of PLDLA membranes for temporary implantation was evaluated. PLDLA membranes were prepared with the solvent evaporation technique and characterized by differential scanning calorimetry, gel permeation chromatography, thermogravimetric analysis, scanning electron microscopy and traction tests. The glass transition temperature of the membranes was 59 ºC. Degradation started around 340 ºC during the second week showing pores and fissures on the broken surface. Evident degradation was observed after 16 weeks. Microscopy showed that before degradation PLDLA membranes presented no pores. PLDLA properties of resistance to traction and elasticity module were maintained until the 8th week, and after the 16th week there was a sharp reduction of these properties due to degradation. PLDLA membranes present excellent potential as temporary implantation given their degradation characteristics.
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spelling In vitro degradation of Poly-L-co-D, L-lactic acid membranespoly-L-co-DL-lactic acidmembranesdegradationPoly-L-co-D.L-lactic (PLDLA) is a bioresorbable polymer whose properties have been studied for degradation sensitivity and its application in medicine. In this study, the potential of PLDLA membranes for temporary implantation was evaluated. PLDLA membranes were prepared with the solvent evaporation technique and characterized by differential scanning calorimetry, gel permeation chromatography, thermogravimetric analysis, scanning electron microscopy and traction tests. The glass transition temperature of the membranes was 59 ºC. Degradation started around 340 ºC during the second week showing pores and fissures on the broken surface. Evident degradation was observed after 16 weeks. Microscopy showed that before degradation PLDLA membranes presented no pores. PLDLA properties of resistance to traction and elasticity module were maintained until the 8th week, and after the 16th week there was a sharp reduction of these properties due to degradation. PLDLA membranes present excellent potential as temporary implantation given their degradation characteristics.ABM, ABC, ABPol2013-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392013000100028Materials Research v.16 n.1 2013reponame:Materials research (São Carlos. Online)instname:Universidade Federal de São Carlos (UFSCAR)instacron:ABM ABC ABPOL10.1590/S1516-14392012005000154info:eu-repo/semantics/openAccessBaraúna,GrazielleCoraça-Huber,Débora CristinaDuek,Eliana Aparecida de Rezendeeng2013-01-31T00:00:00Zoai:scielo:S1516-14392013000100028Revistahttp://www.scielo.br/mrPUBhttps://old.scielo.br/oai/scielo-oai.phpdedz@power.ufscar.br1980-53731516-1439opendoar:2013-01-31T00:00Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)false
dc.title.none.fl_str_mv In vitro degradation of Poly-L-co-D, L-lactic acid membranes
title In vitro degradation of Poly-L-co-D, L-lactic acid membranes
spellingShingle In vitro degradation of Poly-L-co-D, L-lactic acid membranes
Baraúna,Grazielle
poly-L-co-D
L-lactic acid
membranes
degradation
title_short In vitro degradation of Poly-L-co-D, L-lactic acid membranes
title_full In vitro degradation of Poly-L-co-D, L-lactic acid membranes
title_fullStr In vitro degradation of Poly-L-co-D, L-lactic acid membranes
title_full_unstemmed In vitro degradation of Poly-L-co-D, L-lactic acid membranes
title_sort In vitro degradation of Poly-L-co-D, L-lactic acid membranes
author Baraúna,Grazielle
author_facet Baraúna,Grazielle
Coraça-Huber,Débora Cristina
Duek,Eliana Aparecida de Rezende
author_role author
author2 Coraça-Huber,Débora Cristina
Duek,Eliana Aparecida de Rezende
author2_role author
author
dc.contributor.author.fl_str_mv Baraúna,Grazielle
Coraça-Huber,Débora Cristina
Duek,Eliana Aparecida de Rezende
dc.subject.por.fl_str_mv poly-L-co-D
L-lactic acid
membranes
degradation
topic poly-L-co-D
L-lactic acid
membranes
degradation
description Poly-L-co-D.L-lactic (PLDLA) is a bioresorbable polymer whose properties have been studied for degradation sensitivity and its application in medicine. In this study, the potential of PLDLA membranes for temporary implantation was evaluated. PLDLA membranes were prepared with the solvent evaporation technique and characterized by differential scanning calorimetry, gel permeation chromatography, thermogravimetric analysis, scanning electron microscopy and traction tests. The glass transition temperature of the membranes was 59 ºC. Degradation started around 340 ºC during the second week showing pores and fissures on the broken surface. Evident degradation was observed after 16 weeks. Microscopy showed that before degradation PLDLA membranes presented no pores. PLDLA properties of resistance to traction and elasticity module were maintained until the 8th week, and after the 16th week there was a sharp reduction of these properties due to degradation. PLDLA membranes present excellent potential as temporary implantation given their degradation characteristics.
publishDate 2013
dc.date.none.fl_str_mv 2013-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392013000100028
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392013000100028
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-14392012005000154
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv ABM, ABC, ABPol
publisher.none.fl_str_mv ABM, ABC, ABPol
dc.source.none.fl_str_mv Materials Research v.16 n.1 2013
reponame:Materials research (São Carlos. Online)
instname:Universidade Federal de São Carlos (UFSCAR)
instacron:ABM ABC ABPOL
instname_str Universidade Federal de São Carlos (UFSCAR)
instacron_str ABM ABC ABPOL
institution ABM ABC ABPOL
reponame_str Materials research (São Carlos. Online)
collection Materials research (São Carlos. Online)
repository.name.fl_str_mv Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)
repository.mail.fl_str_mv dedz@power.ufscar.br
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