Prevalence of HLA DQB1*0602 allele in patients with migraine

• Autor(a) principal: Coelho,Fernando Morgadinho Santos
• Data de Publicação: 2007
• Outros Autores: Pradella-Hallinan,Márcia, Abud,Paulo Corrêa, Predazzoli Neto,Mario, Moreira,Fabio, Bittencourt,Lia Rita Azeredo, Peres,Mario Fernandes Pietro, Tufik,Sérgio
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos de neuro-psiquiatria (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000700005
• topic: migraine; narcolepsy; HLA DQB1*0602 allele; genetics

BACKGROUND: Studies have shown a high prevalence of migraine among narcoleptic patients. HLA-DQB1*0602 and HLA DRB1 alleles are closely associated with narcolepsy. An increase in the HLA-DRB1 allele frequency in patients with visual aura has raised greater awareness of the genetic background in migraine. PURPOSE: Since the regions DR and DQ of the HLA are in tightly linkage desiquilibrium we hypothesize that HLA-DQB1*0602 might be associated to the pathophysiology of migraine. METHOD: We analyzed the presence of HLA DQB1*0602 allele in 50 healthy subjects with no history of migraine, 53 patients with migraine without aura and 52 patients with migraine with aura. RESULTS: There was no difference in the frequency of HLA DQB1*0602 allele when control subjects and all patients were compared. We failed to note any difference in frequencies when comparing migraine patients with and without aura. CONCLUSION: Further studies with different patient populations, with other hypothalamic markers (melatonin, hypocretin) in migraine patients may shed light on to its pathophysiology.