Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis

Detalhes bibliográficos
Autor(a) principal: Silva,Hidelberto Matos
Data de Publicação: 2017
Outros Autores: Vinaud,Marina Clare, Lino Júnior,Ruy de Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000200005
Resumo: ABSTRACT Neurocysticercosis (NCC) is the most severe clinical manifestation of cysticercosis. One of the factors responsible for its symptomatology is the host inflammatory response. Therefore the influence of interleukin 4 (IL-4) on the induction of encephalitis in experimental NCC was evaluated. Methods BALB/c (WT) and BALB/c (IL-4-KO) mice were inoculated intracranially with Taenia crassiceps cysticerci and euthanized at 7, 30, 60 and 90 days later, the encephala removed and histopathologically analyzed. Results The absence of IL-4 induced greater parasitism. In the initial phase of the infection, IL-4-KO showed a lower intensity in the inflammatory infiltration of polimorphonuclear cells in the host-parasite interface and intra-parenquimatous edema. The IL-4-KO animals, in the late phase of the infection, showed lower intensity of ventriculomegaly, encephalitis, and meningitis, and greater survival of the parasites in comparison with the WT animals. Conclusion The absence of IL-4 induced lower inflammatory infiltration, ventriculomegaly and perivasculitis in experimental NCC.
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spelling Experimental neurocysticercosis: absence of IL-4 induces lower encephalitisneurocysticercosisTaenia crassicepsencephalitisinterleukin-4ABSTRACT Neurocysticercosis (NCC) is the most severe clinical manifestation of cysticercosis. One of the factors responsible for its symptomatology is the host inflammatory response. Therefore the influence of interleukin 4 (IL-4) on the induction of encephalitis in experimental NCC was evaluated. Methods BALB/c (WT) and BALB/c (IL-4-KO) mice were inoculated intracranially with Taenia crassiceps cysticerci and euthanized at 7, 30, 60 and 90 days later, the encephala removed and histopathologically analyzed. Results The absence of IL-4 induced greater parasitism. In the initial phase of the infection, IL-4-KO showed a lower intensity in the inflammatory infiltration of polimorphonuclear cells in the host-parasite interface and intra-parenquimatous edema. The IL-4-KO animals, in the late phase of the infection, showed lower intensity of ventriculomegaly, encephalitis, and meningitis, and greater survival of the parasites in comparison with the WT animals. Conclusion The absence of IL-4 induced lower inflammatory infiltration, ventriculomegaly and perivasculitis in experimental NCC.Academia Brasileira de Neurologia - ABNEURO2017-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000200005Arquivos de Neuro-Psiquiatria v.75 n.2 2017reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20160194info:eu-repo/semantics/openAccessSilva,Hidelberto MatosVinaud,Marina ClareLino Júnior,Ruy de Souzaeng2017-02-17T00:00:00Zoai:scielo:S0004-282X2017000200005Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2017-02-17T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis
title Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis
spellingShingle Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis
Silva,Hidelberto Matos
neurocysticercosis
Taenia crassiceps
encephalitis
interleukin-4
title_short Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis
title_full Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis
title_fullStr Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis
title_full_unstemmed Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis
title_sort Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis
author Silva,Hidelberto Matos
author_facet Silva,Hidelberto Matos
Vinaud,Marina Clare
Lino Júnior,Ruy de Souza
author_role author
author2 Vinaud,Marina Clare
Lino Júnior,Ruy de Souza
author2_role author
author
dc.contributor.author.fl_str_mv Silva,Hidelberto Matos
Vinaud,Marina Clare
Lino Júnior,Ruy de Souza
dc.subject.por.fl_str_mv neurocysticercosis
Taenia crassiceps
encephalitis
interleukin-4
topic neurocysticercosis
Taenia crassiceps
encephalitis
interleukin-4
description ABSTRACT Neurocysticercosis (NCC) is the most severe clinical manifestation of cysticercosis. One of the factors responsible for its symptomatology is the host inflammatory response. Therefore the influence of interleukin 4 (IL-4) on the induction of encephalitis in experimental NCC was evaluated. Methods BALB/c (WT) and BALB/c (IL-4-KO) mice were inoculated intracranially with Taenia crassiceps cysticerci and euthanized at 7, 30, 60 and 90 days later, the encephala removed and histopathologically analyzed. Results The absence of IL-4 induced greater parasitism. In the initial phase of the infection, IL-4-KO showed a lower intensity in the inflammatory infiltration of polimorphonuclear cells in the host-parasite interface and intra-parenquimatous edema. The IL-4-KO animals, in the late phase of the infection, showed lower intensity of ventriculomegaly, encephalitis, and meningitis, and greater survival of the parasites in comparison with the WT animals. Conclusion The absence of IL-4 induced lower inflammatory infiltration, ventriculomegaly and perivasculitis in experimental NCC.
publishDate 2017
dc.date.none.fl_str_mv 2017-02-01
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000200005
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282x20160194
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dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.75 n.2 2017
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
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reponame_str Arquivos de neuro-psiquiatria (Online)
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repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
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