Prognostic factors predicting a fatal outcome in HIV-negative children with neurotuberculosis
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000500015 |
Resumo: | OBJECTIVE: To identify prognostic factors predicting a fatal outcome in HIV-negative children with neurotuberculosis based on clinical, epidemiological, and laboratory findings. METHOD: The clinical records of all in-patients diagnosed with neurotuberculosis from 1982 to 2005 were evaluated retrospectively. The following prognostic parameters were examined: gender, age, close contact with a tuberculosis-infected individual, vaccination for bacillus Calmette-Guérin, purified protein derivative (PPD) of tuberculin results, concomitant miliary tuberculosis, seizures, CSF results, and hydrocephalus. RESULTS: One hundred forty-one patients diagnosed with neurotuberculosis were included. Seventeen percent of the cases resulted in death. The factors that were correlated with a negative outcome included lack of contact with a tuberculosis-infected individual, negative PPD reaction, coma, and longer hospitalisation time. A multiple logistic regression analysis was performed to identify which of these factors most often resulted in death. CONCLUSION: Coma at diagnosis, lack of tuberculosis contact, and a non-reactive PPD were the most important predictors of fatality in patients with neurotuberculosis |
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Prognostic factors predicting a fatal outcome in HIV-negative children with neurotuberculosistuberculosismeningitiscentral nervous systemprognosischildOBJECTIVE: To identify prognostic factors predicting a fatal outcome in HIV-negative children with neurotuberculosis based on clinical, epidemiological, and laboratory findings. METHOD: The clinical records of all in-patients diagnosed with neurotuberculosis from 1982 to 2005 were evaluated retrospectively. The following prognostic parameters were examined: gender, age, close contact with a tuberculosis-infected individual, vaccination for bacillus Calmette-Guérin, purified protein derivative (PPD) of tuberculin results, concomitant miliary tuberculosis, seizures, CSF results, and hydrocephalus. RESULTS: One hundred forty-one patients diagnosed with neurotuberculosis were included. Seventeen percent of the cases resulted in death. The factors that were correlated with a negative outcome included lack of contact with a tuberculosis-infected individual, negative PPD reaction, coma, and longer hospitalisation time. A multiple logistic regression analysis was performed to identify which of these factors most often resulted in death. CONCLUSION: Coma at diagnosis, lack of tuberculosis contact, and a non-reactive PPD were the most important predictors of fatality in patients with neurotuberculosisAcademia Brasileira de Neurologia - ABNEURO2010-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000500015Arquivos de Neuro-Psiquiatria v.68 n.5 2010reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2010000500015info:eu-repo/semantics/openAccessRodrigues,Murilo GimenesLin,JaimeMasruha,Marcelo RodriguesVilanova,Luiz Celso PereiraMinett,Thais Soares Cianciarulloeng2010-10-20T00:00:00Zoai:scielo:S0004-282X2010000500015Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2010-10-20T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Prognostic factors predicting a fatal outcome in HIV-negative children with neurotuberculosis |
title |
Prognostic factors predicting a fatal outcome in HIV-negative children with neurotuberculosis |
spellingShingle |
Prognostic factors predicting a fatal outcome in HIV-negative children with neurotuberculosis Rodrigues,Murilo Gimenes tuberculosis meningitis central nervous system prognosis child |
title_short |
Prognostic factors predicting a fatal outcome in HIV-negative children with neurotuberculosis |
title_full |
Prognostic factors predicting a fatal outcome in HIV-negative children with neurotuberculosis |
title_fullStr |
Prognostic factors predicting a fatal outcome in HIV-negative children with neurotuberculosis |
title_full_unstemmed |
Prognostic factors predicting a fatal outcome in HIV-negative children with neurotuberculosis |
title_sort |
Prognostic factors predicting a fatal outcome in HIV-negative children with neurotuberculosis |
author |
Rodrigues,Murilo Gimenes |
author_facet |
Rodrigues,Murilo Gimenes Lin,Jaime Masruha,Marcelo Rodrigues Vilanova,Luiz Celso Pereira Minett,Thais Soares Cianciarullo |
author_role |
author |
author2 |
Lin,Jaime Masruha,Marcelo Rodrigues Vilanova,Luiz Celso Pereira Minett,Thais Soares Cianciarullo |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Rodrigues,Murilo Gimenes Lin,Jaime Masruha,Marcelo Rodrigues Vilanova,Luiz Celso Pereira Minett,Thais Soares Cianciarullo |
dc.subject.por.fl_str_mv |
tuberculosis meningitis central nervous system prognosis child |
topic |
tuberculosis meningitis central nervous system prognosis child |
description |
OBJECTIVE: To identify prognostic factors predicting a fatal outcome in HIV-negative children with neurotuberculosis based on clinical, epidemiological, and laboratory findings. METHOD: The clinical records of all in-patients diagnosed with neurotuberculosis from 1982 to 2005 were evaluated retrospectively. The following prognostic parameters were examined: gender, age, close contact with a tuberculosis-infected individual, vaccination for bacillus Calmette-Guérin, purified protein derivative (PPD) of tuberculin results, concomitant miliary tuberculosis, seizures, CSF results, and hydrocephalus. RESULTS: One hundred forty-one patients diagnosed with neurotuberculosis were included. Seventeen percent of the cases resulted in death. The factors that were correlated with a negative outcome included lack of contact with a tuberculosis-infected individual, negative PPD reaction, coma, and longer hospitalisation time. A multiple logistic regression analysis was performed to identify which of these factors most often resulted in death. CONCLUSION: Coma at diagnosis, lack of tuberculosis contact, and a non-reactive PPD were the most important predictors of fatality in patients with neurotuberculosis |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000500015 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000500015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2010000500015 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.68 n.5 2010 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212769401405440 |