Merosin-positive congenital muscular dystrophy: neuroimaging findings

Detalhes bibliográficos
Autor(a) principal: Matta,André Palma da Cunha
Data de Publicação: 2007
Outros Autores: Gonsalves,Márcia de Castro Diniz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000100035
Resumo: Congenital muscle dystrophy (CMD) is a heterogeneous group of autosomal recessive myopathies. It is known that CMD may affect the central nervous system (CNS). Some authors have shown that merosin-negative CMD patients may have encephalic metabolic disturbances. In order to study metabolic changes within the brain, the authors performed a magnetic resonance spectroscopy (MRS) study in a 1-year-old girl with merosin-positive CMD (MP-CMD). MRS of brain demonstrated that NAA/Cr ratio was decreased (1.52), while Cho/Cr ratio was increased (1.78). These findings suggest that metabolic changes in CNS can also be found in patients with MP-CMD.
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spelling Merosin-positive congenital muscular dystrophy: neuroimaging findingscongenital muscle dystrophymerosinmagnetic resonanceCongenital muscle dystrophy (CMD) is a heterogeneous group of autosomal recessive myopathies. It is known that CMD may affect the central nervous system (CNS). Some authors have shown that merosin-negative CMD patients may have encephalic metabolic disturbances. In order to study metabolic changes within the brain, the authors performed a magnetic resonance spectroscopy (MRS) study in a 1-year-old girl with merosin-positive CMD (MP-CMD). MRS of brain demonstrated that NAA/Cr ratio was decreased (1.52), while Cho/Cr ratio was increased (1.78). These findings suggest that metabolic changes in CNS can also be found in patients with MP-CMD.Academia Brasileira de Neurologia - ABNEURO2007-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000100035Arquivos de Neuro-Psiquiatria v.65 n.1 2007reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2007000100035info:eu-repo/semantics/openAccessMatta,André Palma da CunhaGonsalves,Márcia de Castro Dinizeng2007-03-23T00:00:00Zoai:scielo:S0004-282X2007000100035Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2007-03-23T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Merosin-positive congenital muscular dystrophy: neuroimaging findings
title Merosin-positive congenital muscular dystrophy: neuroimaging findings
spellingShingle Merosin-positive congenital muscular dystrophy: neuroimaging findings
Matta,André Palma da Cunha
congenital muscle dystrophy
merosin
magnetic resonance
title_short Merosin-positive congenital muscular dystrophy: neuroimaging findings
title_full Merosin-positive congenital muscular dystrophy: neuroimaging findings
title_fullStr Merosin-positive congenital muscular dystrophy: neuroimaging findings
title_full_unstemmed Merosin-positive congenital muscular dystrophy: neuroimaging findings
title_sort Merosin-positive congenital muscular dystrophy: neuroimaging findings
author Matta,André Palma da Cunha
author_facet Matta,André Palma da Cunha
Gonsalves,Márcia de Castro Diniz
author_role author
author2 Gonsalves,Márcia de Castro Diniz
author2_role author
dc.contributor.author.fl_str_mv Matta,André Palma da Cunha
Gonsalves,Márcia de Castro Diniz
dc.subject.por.fl_str_mv congenital muscle dystrophy
merosin
magnetic resonance
topic congenital muscle dystrophy
merosin
magnetic resonance
description Congenital muscle dystrophy (CMD) is a heterogeneous group of autosomal recessive myopathies. It is known that CMD may affect the central nervous system (CNS). Some authors have shown that merosin-negative CMD patients may have encephalic metabolic disturbances. In order to study metabolic changes within the brain, the authors performed a magnetic resonance spectroscopy (MRS) study in a 1-year-old girl with merosin-positive CMD (MP-CMD). MRS of brain demonstrated that NAA/Cr ratio was decreased (1.52), while Cho/Cr ratio was increased (1.78). These findings suggest that metabolic changes in CNS can also be found in patients with MP-CMD.
publishDate 2007
dc.date.none.fl_str_mv 2007-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000100035
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2007000100035
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.65 n.1 2007
reponame:Arquivos de neuro-psiquiatria (Online)
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reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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