Congenital destructive hemispheric lesions and epilepsy: clinical features and relevance of associated hippocampal atrophy
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2000000600003 |
Resumo: | We studied the clinical, EEG and MRI findings in 19 patients with epilepsy secondary to congenital destructive hemispheric insults. Patients were divided in two groups: 10 with cystic lesions (group 1), and 9 with atrophic lesions (group 2). Seizure and EEG features, as well as developmental sequelae were similar between the two groups, except for the finding that patients of group 2 more commonly presented seizures with more than one semiological type. MRI showed hyperintense T2 signal extending beyond the lesion in almost all patients of both groups, and it was more diffuse in group 2. Associated hippocampal atrophy (HA) was observed in 70% of group 1 patients and 77.7% of group 2, and it was not correlated with duration of epilepsy or seizure frequency. There was a good concordance between HA and electroclinical localization. The high prevalence of associated HA in both groups suggests a common pathogenesis with the more obvious lesion. Our findings indicate that in some of these patients with extensive destructive lesions, there may be a more circumscribed epileptogenic area, particularly in those with cystic lesions and HA, leading to a potential rationale for effective surgical treatment. |
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Arquivos de neuro-psiquiatria (Online) |
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Congenital destructive hemispheric lesions and epilepsy: clinical features and relevance of associated hippocampal atrophyepilepsymagnetic resonance imagehippocampal atrophyWe studied the clinical, EEG and MRI findings in 19 patients with epilepsy secondary to congenital destructive hemispheric insults. Patients were divided in two groups: 10 with cystic lesions (group 1), and 9 with atrophic lesions (group 2). Seizure and EEG features, as well as developmental sequelae were similar between the two groups, except for the finding that patients of group 2 more commonly presented seizures with more than one semiological type. MRI showed hyperintense T2 signal extending beyond the lesion in almost all patients of both groups, and it was more diffuse in group 2. Associated hippocampal atrophy (HA) was observed in 70% of group 1 patients and 77.7% of group 2, and it was not correlated with duration of epilepsy or seizure frequency. There was a good concordance between HA and electroclinical localization. The high prevalence of associated HA in both groups suggests a common pathogenesis with the more obvious lesion. Our findings indicate that in some of these patients with extensive destructive lesions, there may be a more circumscribed epileptogenic area, particularly in those with cystic lesions and HA, leading to a potential rationale for effective surgical treatment.Academia Brasileira de Neurologia - ABNEURO2000-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2000000600003Arquivos de Neuro-Psiquiatria v.58 n.4 2000reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2000000600003info:eu-repo/semantics/openAccessTEIXEIRA,RICARDO A.LEONE,ANDREA A. A.HONORATO,DONIZETI C.DAMASCENO,BENITO P.GUERREIRO,CARLOS A. M.CENDES,FERNANDOeng2000-12-01T00:00:00Zoai:scielo:S0004-282X2000000600003Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2000-12-01T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Congenital destructive hemispheric lesions and epilepsy: clinical features and relevance of associated hippocampal atrophy |
title |
Congenital destructive hemispheric lesions and epilepsy: clinical features and relevance of associated hippocampal atrophy |
spellingShingle |
Congenital destructive hemispheric lesions and epilepsy: clinical features and relevance of associated hippocampal atrophy TEIXEIRA,RICARDO A. epilepsy magnetic resonance image hippocampal atrophy |
title_short |
Congenital destructive hemispheric lesions and epilepsy: clinical features and relevance of associated hippocampal atrophy |
title_full |
Congenital destructive hemispheric lesions and epilepsy: clinical features and relevance of associated hippocampal atrophy |
title_fullStr |
Congenital destructive hemispheric lesions and epilepsy: clinical features and relevance of associated hippocampal atrophy |
title_full_unstemmed |
Congenital destructive hemispheric lesions and epilepsy: clinical features and relevance of associated hippocampal atrophy |
title_sort |
Congenital destructive hemispheric lesions and epilepsy: clinical features and relevance of associated hippocampal atrophy |
author |
TEIXEIRA,RICARDO A. |
author_facet |
TEIXEIRA,RICARDO A. LEONE,ANDREA A. A. HONORATO,DONIZETI C. DAMASCENO,BENITO P. GUERREIRO,CARLOS A. M. CENDES,FERNANDO |
author_role |
author |
author2 |
LEONE,ANDREA A. A. HONORATO,DONIZETI C. DAMASCENO,BENITO P. GUERREIRO,CARLOS A. M. CENDES,FERNANDO |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
TEIXEIRA,RICARDO A. LEONE,ANDREA A. A. HONORATO,DONIZETI C. DAMASCENO,BENITO P. GUERREIRO,CARLOS A. M. CENDES,FERNANDO |
dc.subject.por.fl_str_mv |
epilepsy magnetic resonance image hippocampal atrophy |
topic |
epilepsy magnetic resonance image hippocampal atrophy |
description |
We studied the clinical, EEG and MRI findings in 19 patients with epilepsy secondary to congenital destructive hemispheric insults. Patients were divided in two groups: 10 with cystic lesions (group 1), and 9 with atrophic lesions (group 2). Seizure and EEG features, as well as developmental sequelae were similar between the two groups, except for the finding that patients of group 2 more commonly presented seizures with more than one semiological type. MRI showed hyperintense T2 signal extending beyond the lesion in almost all patients of both groups, and it was more diffuse in group 2. Associated hippocampal atrophy (HA) was observed in 70% of group 1 patients and 77.7% of group 2, and it was not correlated with duration of epilepsy or seizure frequency. There was a good concordance between HA and electroclinical localization. The high prevalence of associated HA in both groups suggests a common pathogenesis with the more obvious lesion. Our findings indicate that in some of these patients with extensive destructive lesions, there may be a more circumscribed epileptogenic area, particularly in those with cystic lesions and HA, leading to a potential rationale for effective surgical treatment. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2000000600003 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2000000600003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2000000600003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.58 n.4 2000 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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