Alterations on monoamines concentration in rat hippocampus produced by lipoic acid
Autor(a) principal: | |
---|---|
Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000300006 |
Resumo: | The purposes of the present study were to verify monoamines (dopamine (DA), norepinephrine (NE), serotonin (5-HT)), and their metabolites (3,4-hydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA)) contents in rat hippocampus after lipoic acid (LA) administration. Wistar rats were treated with 0.9% saline (i.p., control group) and LA (10, 20 or 30 mg/kg, i.p., LA10, LA20 and LA30 groups, respectively). After the treatments all groups were observed for 24 h. The NE and DA levels were increased only in 20 mg/kg dose of LA in rat hippocampus. Serotonin content and in their metabolite 5-HIAA levels was decreased in same dose of LA. On the other hand, in DOPAC and HVA levels did not show any significant change. The alterations in hippocampal monoamines can be suggested as a possible of brain mechanism of action from this antioxidant. The outcome of the study may have therapeutic implications in the treatment of neurodegenerative diseases. |
id |
ABNEURO-1_1bd25eb26bacc25da4f07a19d74d2c90 |
---|---|
oai_identifier_str |
oai:scielo:S0004-282X2010000300006 |
network_acronym_str |
ABNEURO-1 |
network_name_str |
Arquivos de neuro-psiquiatria (Online) |
repository_id_str |
|
spelling |
Alterations on monoamines concentration in rat hippocampus produced by lipoic acidlipoic acidhippocampusdopaminenorepinephrineserotoninThe purposes of the present study were to verify monoamines (dopamine (DA), norepinephrine (NE), serotonin (5-HT)), and their metabolites (3,4-hydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA)) contents in rat hippocampus after lipoic acid (LA) administration. Wistar rats were treated with 0.9% saline (i.p., control group) and LA (10, 20 or 30 mg/kg, i.p., LA10, LA20 and LA30 groups, respectively). After the treatments all groups were observed for 24 h. The NE and DA levels were increased only in 20 mg/kg dose of LA in rat hippocampus. Serotonin content and in their metabolite 5-HIAA levels was decreased in same dose of LA. On the other hand, in DOPAC and HVA levels did not show any significant change. The alterations in hippocampal monoamines can be suggested as a possible of brain mechanism of action from this antioxidant. The outcome of the study may have therapeutic implications in the treatment of neurodegenerative diseases.Academia Brasileira de Neurologia - ABNEURO2010-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000300006Arquivos de Neuro-Psiquiatria v.68 n.3 2010reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2010000300006info:eu-repo/semantics/openAccessSantos,Ítala Mônica de SalesFreitas,Rizângela Lyne Mendes deSaldanha,Gláucio BarrosTomé,Adriana da RochaJordán,JoaquínFreitas,Rivelilson Mendes deeng2010-06-24T00:00:00Zoai:scielo:S0004-282X2010000300006Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2010-06-24T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Alterations on monoamines concentration in rat hippocampus produced by lipoic acid |
title |
Alterations on monoamines concentration in rat hippocampus produced by lipoic acid |
spellingShingle |
Alterations on monoamines concentration in rat hippocampus produced by lipoic acid Santos,Ítala Mônica de Sales lipoic acid hippocampus dopamine norepinephrine serotonin |
title_short |
Alterations on monoamines concentration in rat hippocampus produced by lipoic acid |
title_full |
Alterations on monoamines concentration in rat hippocampus produced by lipoic acid |
title_fullStr |
Alterations on monoamines concentration in rat hippocampus produced by lipoic acid |
title_full_unstemmed |
Alterations on monoamines concentration in rat hippocampus produced by lipoic acid |
title_sort |
Alterations on monoamines concentration in rat hippocampus produced by lipoic acid |
author |
Santos,Ítala Mônica de Sales |
author_facet |
Santos,Ítala Mônica de Sales Freitas,Rizângela Lyne Mendes de Saldanha,Gláucio Barros Tomé,Adriana da Rocha Jordán,Joaquín Freitas,Rivelilson Mendes de |
author_role |
author |
author2 |
Freitas,Rizângela Lyne Mendes de Saldanha,Gláucio Barros Tomé,Adriana da Rocha Jordán,Joaquín Freitas,Rivelilson Mendes de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Santos,Ítala Mônica de Sales Freitas,Rizângela Lyne Mendes de Saldanha,Gláucio Barros Tomé,Adriana da Rocha Jordán,Joaquín Freitas,Rivelilson Mendes de |
dc.subject.por.fl_str_mv |
lipoic acid hippocampus dopamine norepinephrine serotonin |
topic |
lipoic acid hippocampus dopamine norepinephrine serotonin |
description |
The purposes of the present study were to verify monoamines (dopamine (DA), norepinephrine (NE), serotonin (5-HT)), and their metabolites (3,4-hydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA)) contents in rat hippocampus after lipoic acid (LA) administration. Wistar rats were treated with 0.9% saline (i.p., control group) and LA (10, 20 or 30 mg/kg, i.p., LA10, LA20 and LA30 groups, respectively). After the treatments all groups were observed for 24 h. The NE and DA levels were increased only in 20 mg/kg dose of LA in rat hippocampus. Serotonin content and in their metabolite 5-HIAA levels was decreased in same dose of LA. On the other hand, in DOPAC and HVA levels did not show any significant change. The alterations in hippocampal monoamines can be suggested as a possible of brain mechanism of action from this antioxidant. The outcome of the study may have therapeutic implications in the treatment of neurodegenerative diseases. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000300006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000300006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2010000300006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.68 n.3 2010 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
_version_ |
1754212768501727232 |