Diagnostic methods for extra-temporal neocortical focal epilepsies: present and future
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000100025 |
Resumo: | The progress of epilepsies diagnosis has been great, but, amongst the diagnostic detailing that demand research, one of the most important is the essential lateralization and localization of epileptogenic zone, considered as the cerebral cortex region, that removed, will result in a free state of seizures. The present study aims to analyze the possible uses of proton spectroscopy for clinical and pre-surgical evaluation of focal extratemporal epilepsies, since this group presents the highest difficulty degree for lateralizing and locating epileptogenic zones. In almost all cases, a non invasive diagnosis can be performed using routine electroencephalography, video-electroencephalography - considered as gold standard, and magnetic resonance imaging. However, when the results of these exams are contradictory, some patients need invasive techniques, as the intra-cranial video-EEG, using deep electrodes, sub-dural strip and grid, that are associated with increased diagnostic cost and risk of complications, as cerebral hemorrhages and intra-cranial infections. Proton spectroscopy appears as a possibility, given its capacity to evaluate cerebral metabolism, by N-acetyl-aspartate (NAA), creatine (Cre) and choline (Cho) concentrations, amongst other metabolites. This non invasive method may provide time reduction of this evaluation and reliable level improvement for this topographical diagnosis. |
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Diagnostic methods for extra-temporal neocortical focal epilepsies: present and futureextratemporal neocortical epilepsiesdiagnostic methodsmagnetic resonance spectroscopypre-surgical evaluationThe progress of epilepsies diagnosis has been great, but, amongst the diagnostic detailing that demand research, one of the most important is the essential lateralization and localization of epileptogenic zone, considered as the cerebral cortex region, that removed, will result in a free state of seizures. The present study aims to analyze the possible uses of proton spectroscopy for clinical and pre-surgical evaluation of focal extratemporal epilepsies, since this group presents the highest difficulty degree for lateralizing and locating epileptogenic zones. In almost all cases, a non invasive diagnosis can be performed using routine electroencephalography, video-electroencephalography - considered as gold standard, and magnetic resonance imaging. However, when the results of these exams are contradictory, some patients need invasive techniques, as the intra-cranial video-EEG, using deep electrodes, sub-dural strip and grid, that are associated with increased diagnostic cost and risk of complications, as cerebral hemorrhages and intra-cranial infections. Proton spectroscopy appears as a possibility, given its capacity to evaluate cerebral metabolism, by N-acetyl-aspartate (NAA), creatine (Cre) and choline (Cho) concentrations, amongst other metabolites. This non invasive method may provide time reduction of this evaluation and reliable level improvement for this topographical diagnosis.Academia Brasileira de Neurologia - ABNEURO2010-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000100025Arquivos de Neuro-Psiquiatria v.68 n.1 2010reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2010000100025info:eu-repo/semantics/openAccessLeite,Ricardo André AmorimOtaduy,Maria Concépcion GarciaSilva,Gilson Edmar Gonçalves eFerreira,Maria Lúcia BritoAragão,Maria de Fátima Vascoeng2010-09-22T00:00:00Zoai:scielo:S0004-282X2010000100025Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2010-09-22T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Diagnostic methods for extra-temporal neocortical focal epilepsies: present and future |
title |
Diagnostic methods for extra-temporal neocortical focal epilepsies: present and future |
spellingShingle |
Diagnostic methods for extra-temporal neocortical focal epilepsies: present and future Leite,Ricardo André Amorim extratemporal neocortical epilepsies diagnostic methods magnetic resonance spectroscopy pre-surgical evaluation |
title_short |
Diagnostic methods for extra-temporal neocortical focal epilepsies: present and future |
title_full |
Diagnostic methods for extra-temporal neocortical focal epilepsies: present and future |
title_fullStr |
Diagnostic methods for extra-temporal neocortical focal epilepsies: present and future |
title_full_unstemmed |
Diagnostic methods for extra-temporal neocortical focal epilepsies: present and future |
title_sort |
Diagnostic methods for extra-temporal neocortical focal epilepsies: present and future |
author |
Leite,Ricardo André Amorim |
author_facet |
Leite,Ricardo André Amorim Otaduy,Maria Concépcion Garcia Silva,Gilson Edmar Gonçalves e Ferreira,Maria Lúcia Brito Aragão,Maria de Fátima Vasco |
author_role |
author |
author2 |
Otaduy,Maria Concépcion Garcia Silva,Gilson Edmar Gonçalves e Ferreira,Maria Lúcia Brito Aragão,Maria de Fátima Vasco |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Leite,Ricardo André Amorim Otaduy,Maria Concépcion Garcia Silva,Gilson Edmar Gonçalves e Ferreira,Maria Lúcia Brito Aragão,Maria de Fátima Vasco |
dc.subject.por.fl_str_mv |
extratemporal neocortical epilepsies diagnostic methods magnetic resonance spectroscopy pre-surgical evaluation |
topic |
extratemporal neocortical epilepsies diagnostic methods magnetic resonance spectroscopy pre-surgical evaluation |
description |
The progress of epilepsies diagnosis has been great, but, amongst the diagnostic detailing that demand research, one of the most important is the essential lateralization and localization of epileptogenic zone, considered as the cerebral cortex region, that removed, will result in a free state of seizures. The present study aims to analyze the possible uses of proton spectroscopy for clinical and pre-surgical evaluation of focal extratemporal epilepsies, since this group presents the highest difficulty degree for lateralizing and locating epileptogenic zones. In almost all cases, a non invasive diagnosis can be performed using routine electroencephalography, video-electroencephalography - considered as gold standard, and magnetic resonance imaging. However, when the results of these exams are contradictory, some patients need invasive techniques, as the intra-cranial video-EEG, using deep electrodes, sub-dural strip and grid, that are associated with increased diagnostic cost and risk of complications, as cerebral hemorrhages and intra-cranial infections. Proton spectroscopy appears as a possibility, given its capacity to evaluate cerebral metabolism, by N-acetyl-aspartate (NAA), creatine (Cre) and choline (Cho) concentrations, amongst other metabolites. This non invasive method may provide time reduction of this evaluation and reliable level improvement for this topographical diagnosis. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000100025 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000100025 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2010000100025 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.68 n.1 2010 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212767951224832 |