Diagnostic methods for extra-temporal neocortical focal epilepsies: present and future

Detalhes bibliográficos
Autor(a) principal: Leite,Ricardo André Amorim
Data de Publicação: 2010
Outros Autores: Otaduy,Maria Concépcion Garcia, Silva,Gilson Edmar Gonçalves e, Ferreira,Maria Lúcia Brito, Aragão,Maria de Fátima Vasco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000100025
Resumo: The progress of epilepsies diagnosis has been great, but, amongst the diagnostic detailing that demand research, one of the most important is the essential lateralization and localization of epileptogenic zone, considered as the cerebral cortex region, that removed, will result in a free state of seizures. The present study aims to analyze the possible uses of proton spectroscopy for clinical and pre-surgical evaluation of focal extratemporal epilepsies, since this group presents the highest difficulty degree for lateralizing and locating epileptogenic zones. In almost all cases, a non invasive diagnosis can be performed using routine electroencephalography, video-electroencephalography - considered as gold standard, and magnetic resonance imaging. However, when the results of these exams are contradictory, some patients need invasive techniques, as the intra-cranial video-EEG, using deep electrodes, sub-dural strip and grid, that are associated with increased diagnostic cost and risk of complications, as cerebral hemorrhages and intra-cranial infections. Proton spectroscopy appears as a possibility, given its capacity to evaluate cerebral metabolism, by N-acetyl-aspartate (NAA), creatine (Cre) and choline (Cho) concentrations, amongst other metabolites. This non invasive method may provide time reduction of this evaluation and reliable level improvement for this topographical diagnosis.
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spelling Diagnostic methods for extra-temporal neocortical focal epilepsies: present and futureextratemporal neocortical epilepsiesdiagnostic methodsmagnetic resonance spectroscopypre-surgical evaluationThe progress of epilepsies diagnosis has been great, but, amongst the diagnostic detailing that demand research, one of the most important is the essential lateralization and localization of epileptogenic zone, considered as the cerebral cortex region, that removed, will result in a free state of seizures. The present study aims to analyze the possible uses of proton spectroscopy for clinical and pre-surgical evaluation of focal extratemporal epilepsies, since this group presents the highest difficulty degree for lateralizing and locating epileptogenic zones. In almost all cases, a non invasive diagnosis can be performed using routine electroencephalography, video-electroencephalography - considered as gold standard, and magnetic resonance imaging. However, when the results of these exams are contradictory, some patients need invasive techniques, as the intra-cranial video-EEG, using deep electrodes, sub-dural strip and grid, that are associated with increased diagnostic cost and risk of complications, as cerebral hemorrhages and intra-cranial infections. Proton spectroscopy appears as a possibility, given its capacity to evaluate cerebral metabolism, by N-acetyl-aspartate (NAA), creatine (Cre) and choline (Cho) concentrations, amongst other metabolites. This non invasive method may provide time reduction of this evaluation and reliable level improvement for this topographical diagnosis.Academia Brasileira de Neurologia - ABNEURO2010-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000100025Arquivos de Neuro-Psiquiatria v.68 n.1 2010reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2010000100025info:eu-repo/semantics/openAccessLeite,Ricardo André AmorimOtaduy,Maria Concépcion GarciaSilva,Gilson Edmar Gonçalves eFerreira,Maria Lúcia BritoAragão,Maria de Fátima Vascoeng2010-09-22T00:00:00Zoai:scielo:S0004-282X2010000100025Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2010-09-22T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Diagnostic methods for extra-temporal neocortical focal epilepsies: present and future
title Diagnostic methods for extra-temporal neocortical focal epilepsies: present and future
spellingShingle Diagnostic methods for extra-temporal neocortical focal epilepsies: present and future
Leite,Ricardo André Amorim
extratemporal neocortical epilepsies
diagnostic methods
magnetic resonance spectroscopy
pre-surgical evaluation
title_short Diagnostic methods for extra-temporal neocortical focal epilepsies: present and future
title_full Diagnostic methods for extra-temporal neocortical focal epilepsies: present and future
title_fullStr Diagnostic methods for extra-temporal neocortical focal epilepsies: present and future
title_full_unstemmed Diagnostic methods for extra-temporal neocortical focal epilepsies: present and future
title_sort Diagnostic methods for extra-temporal neocortical focal epilepsies: present and future
author Leite,Ricardo André Amorim
author_facet Leite,Ricardo André Amorim
Otaduy,Maria Concépcion Garcia
Silva,Gilson Edmar Gonçalves e
Ferreira,Maria Lúcia Brito
Aragão,Maria de Fátima Vasco
author_role author
author2 Otaduy,Maria Concépcion Garcia
Silva,Gilson Edmar Gonçalves e
Ferreira,Maria Lúcia Brito
Aragão,Maria de Fátima Vasco
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Leite,Ricardo André Amorim
Otaduy,Maria Concépcion Garcia
Silva,Gilson Edmar Gonçalves e
Ferreira,Maria Lúcia Brito
Aragão,Maria de Fátima Vasco
dc.subject.por.fl_str_mv extratemporal neocortical epilepsies
diagnostic methods
magnetic resonance spectroscopy
pre-surgical evaluation
topic extratemporal neocortical epilepsies
diagnostic methods
magnetic resonance spectroscopy
pre-surgical evaluation
description The progress of epilepsies diagnosis has been great, but, amongst the diagnostic detailing that demand research, one of the most important is the essential lateralization and localization of epileptogenic zone, considered as the cerebral cortex region, that removed, will result in a free state of seizures. The present study aims to analyze the possible uses of proton spectroscopy for clinical and pre-surgical evaluation of focal extratemporal epilepsies, since this group presents the highest difficulty degree for lateralizing and locating epileptogenic zones. In almost all cases, a non invasive diagnosis can be performed using routine electroencephalography, video-electroencephalography - considered as gold standard, and magnetic resonance imaging. However, when the results of these exams are contradictory, some patients need invasive techniques, as the intra-cranial video-EEG, using deep electrodes, sub-dural strip and grid, that are associated with increased diagnostic cost and risk of complications, as cerebral hemorrhages and intra-cranial infections. Proton spectroscopy appears as a possibility, given its capacity to evaluate cerebral metabolism, by N-acetyl-aspartate (NAA), creatine (Cre) and choline (Cho) concentrations, amongst other metabolites. This non invasive method may provide time reduction of this evaluation and reliable level improvement for this topographical diagnosis.
publishDate 2010
dc.date.none.fl_str_mv 2010-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000100025
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/S0004-282X2010000100025
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.68 n.1 2010
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
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reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
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