Ketoconazole in the treatment of cryptococcosis of the central nervous system

Detalhes bibliográficos
Autor(a) principal: Trevisol-Bittencourt,P. C.
Data de Publicação: 1991
Outros Autores: Sander,J. W. A. S., Silvado,C. S., Wittig,E. O.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1991000200016
Resumo: Two patients with cryptococcosis of the CNS were treated with ketoconazole (KTZ), an imidazole derivative with fungistatic properties; they had either failed standard therapy (Amphotericin-B + 5-Flurocytosine) or suffred intolerable side-effects to it. Both patients were administered KTZ 800 mg/day as monotherapy for six months without interruption and both responded. One month after KTZ therapy was withdrawn, however, a relapse of the infection was seen in one case. Side-effects were minimal during the trial of treatment. KTZ could be a useful drug in some cases of neurocryptococcosis.
id ABNEURO-1_3e0326f8db7afcf5d3387ef0ab8cb043
oai_identifier_str oai:scielo:S0004-282X1991000200016
network_acronym_str ABNEURO-1
network_name_str Arquivos de neuro-psiquiatria (Online)
repository_id_str
spelling Ketoconazole in the treatment of cryptococcosis of the central nervous systemTwo patients with cryptococcosis of the CNS were treated with ketoconazole (KTZ), an imidazole derivative with fungistatic properties; they had either failed standard therapy (Amphotericin-B + 5-Flurocytosine) or suffred intolerable side-effects to it. Both patients were administered KTZ 800 mg/day as monotherapy for six months without interruption and both responded. One month after KTZ therapy was withdrawn, however, a relapse of the infection was seen in one case. Side-effects were minimal during the trial of treatment. KTZ could be a useful drug in some cases of neurocryptococcosis.Academia Brasileira de Neurologia - ABNEURO1991-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1991000200016Arquivos de Neuro-Psiquiatria v.49 n.2 1991reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X1991000200016info:eu-repo/semantics/openAccessTrevisol-Bittencourt,P. C.Sander,J. W. A. S.Silvado,C. S.Wittig,E. O.eng2011-02-22T00:00:00Zoai:scielo:S0004-282X1991000200016Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2011-02-22T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Ketoconazole in the treatment of cryptococcosis of the central nervous system
title Ketoconazole in the treatment of cryptococcosis of the central nervous system
spellingShingle Ketoconazole in the treatment of cryptococcosis of the central nervous system
Trevisol-Bittencourt,P. C.
title_short Ketoconazole in the treatment of cryptococcosis of the central nervous system
title_full Ketoconazole in the treatment of cryptococcosis of the central nervous system
title_fullStr Ketoconazole in the treatment of cryptococcosis of the central nervous system
title_full_unstemmed Ketoconazole in the treatment of cryptococcosis of the central nervous system
title_sort Ketoconazole in the treatment of cryptococcosis of the central nervous system
author Trevisol-Bittencourt,P. C.
author_facet Trevisol-Bittencourt,P. C.
Sander,J. W. A. S.
Silvado,C. S.
Wittig,E. O.
author_role author
author2 Sander,J. W. A. S.
Silvado,C. S.
Wittig,E. O.
author2_role author
author
author
dc.contributor.author.fl_str_mv Trevisol-Bittencourt,P. C.
Sander,J. W. A. S.
Silvado,C. S.
Wittig,E. O.
description Two patients with cryptococcosis of the CNS were treated with ketoconazole (KTZ), an imidazole derivative with fungistatic properties; they had either failed standard therapy (Amphotericin-B + 5-Flurocytosine) or suffred intolerable side-effects to it. Both patients were administered KTZ 800 mg/day as monotherapy for six months without interruption and both responded. One month after KTZ therapy was withdrawn, however, a relapse of the infection was seen in one case. Side-effects were minimal during the trial of treatment. KTZ could be a useful drug in some cases of neurocryptococcosis.
publishDate 1991
dc.date.none.fl_str_mv 1991-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1991000200016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1991000200016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X1991000200016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.49 n.2 1991
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
_version_ 1754212747470438400

Registros relacionados