Effects of crocin on brain oxidative damage and aversive memory in a 6-OHDA model of Parkinson’s disease

Detalhes bibliográficos
Autor(a) principal: Rajaei,Z
Data de Publicação: 2016
Outros Autores: Hosseini,M, Alaei,H
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000900723
Resumo: ABSTRACT The purpose of the present study was to investigate the effect of crocin on brain oxidative damage and memory deficits in a 6-hydroxydopamine (6-OHDA) model of Parkinson’s disease. Male Wistar rats were subjected to unilateral injection of 6-OHDA (16 µg) into the medial forebrain bundle and treated with crocin (30 and 60 mg/kg) for six weeks. The rats were tested for memory performance at six weeks after 6-OHDA infusion, and then were killed for the estimation of biochemical parameters. The increase in thiobarbituric acid reactive substances (TBARS) and nitrite levels in the hippocampus were observed in the 6-OHDA lesioned rats, which was accompanied by memory deficits in a passive avoidance test at the end of week 6. Moreover, treatment with crocin decreased TBARS and nitrite levels in the hippocampus, and improved aversive memory. The present study conclusively demonstrated that crocin acts as an antioxidant and anti-inflammatory agent in the hippocampus of parkinsonian rats and could improve aversive memory through its properties.
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spelling Effects of crocin on brain oxidative damage and aversive memory in a 6-OHDA model of Parkinson’s diseaseCrocin6-hydroxydopamineoxidative stressnitric oxideaversive memorymedial forebrain bundleABSTRACT The purpose of the present study was to investigate the effect of crocin on brain oxidative damage and memory deficits in a 6-hydroxydopamine (6-OHDA) model of Parkinson’s disease. Male Wistar rats were subjected to unilateral injection of 6-OHDA (16 µg) into the medial forebrain bundle and treated with crocin (30 and 60 mg/kg) for six weeks. The rats were tested for memory performance at six weeks after 6-OHDA infusion, and then were killed for the estimation of biochemical parameters. The increase in thiobarbituric acid reactive substances (TBARS) and nitrite levels in the hippocampus were observed in the 6-OHDA lesioned rats, which was accompanied by memory deficits in a passive avoidance test at the end of week 6. Moreover, treatment with crocin decreased TBARS and nitrite levels in the hippocampus, and improved aversive memory. The present study conclusively demonstrated that crocin acts as an antioxidant and anti-inflammatory agent in the hippocampus of parkinsonian rats and could improve aversive memory through its properties.Academia Brasileira de Neurologia - ABNEURO2016-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000900723Arquivos de Neuro-Psiquiatria v.74 n.9 2016reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20160131info:eu-repo/semantics/openAccessRajaei,ZHosseini,MAlaei,Heng2016-09-28T00:00:00Zoai:scielo:S0004-282X2016000900723Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2016-09-28T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Effects of crocin on brain oxidative damage and aversive memory in a 6-OHDA model of Parkinson’s disease
title Effects of crocin on brain oxidative damage and aversive memory in a 6-OHDA model of Parkinson’s disease
spellingShingle Effects of crocin on brain oxidative damage and aversive memory in a 6-OHDA model of Parkinson’s disease
Rajaei,Z
Crocin
6-hydroxydopamine
oxidative stress
nitric oxide
aversive memory
medial forebrain bundle
title_short Effects of crocin on brain oxidative damage and aversive memory in a 6-OHDA model of Parkinson’s disease
title_full Effects of crocin on brain oxidative damage and aversive memory in a 6-OHDA model of Parkinson’s disease
title_fullStr Effects of crocin on brain oxidative damage and aversive memory in a 6-OHDA model of Parkinson’s disease
title_full_unstemmed Effects of crocin on brain oxidative damage and aversive memory in a 6-OHDA model of Parkinson’s disease
title_sort Effects of crocin on brain oxidative damage and aversive memory in a 6-OHDA model of Parkinson’s disease
author Rajaei,Z
author_facet Rajaei,Z
Hosseini,M
Alaei,H
author_role author
author2 Hosseini,M
Alaei,H
author2_role author
author
dc.contributor.author.fl_str_mv Rajaei,Z
Hosseini,M
Alaei,H
dc.subject.por.fl_str_mv Crocin
6-hydroxydopamine
oxidative stress
nitric oxide
aversive memory
medial forebrain bundle
topic Crocin
6-hydroxydopamine
oxidative stress
nitric oxide
aversive memory
medial forebrain bundle
description ABSTRACT The purpose of the present study was to investigate the effect of crocin on brain oxidative damage and memory deficits in a 6-hydroxydopamine (6-OHDA) model of Parkinson’s disease. Male Wistar rats were subjected to unilateral injection of 6-OHDA (16 µg) into the medial forebrain bundle and treated with crocin (30 and 60 mg/kg) for six weeks. The rats were tested for memory performance at six weeks after 6-OHDA infusion, and then were killed for the estimation of biochemical parameters. The increase in thiobarbituric acid reactive substances (TBARS) and nitrite levels in the hippocampus were observed in the 6-OHDA lesioned rats, which was accompanied by memory deficits in a passive avoidance test at the end of week 6. Moreover, treatment with crocin decreased TBARS and nitrite levels in the hippocampus, and improved aversive memory. The present study conclusively demonstrated that crocin acts as an antioxidant and anti-inflammatory agent in the hippocampus of parkinsonian rats and could improve aversive memory through its properties.
publishDate 2016
dc.date.none.fl_str_mv 2016-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000900723
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000900723
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282X20160131
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.74 n.9 2016
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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