Pattern of P50 suppression deficit in patients with epilepsy and individuals with schizophrenia

• Autor(a) principal: Becker,Jefferson
• Data de Publicação: 2011
• Outros Autores: Filho,Irenio Gomes da Silva, Filho,Hélio Fernandes da Silva, Schuch,Alice, Ramos,Fernanda Lia de Paula, Ghisolfi,Eduardo Sörensen, Lara,Diogo Rizzato, Costa,Jaderson Costa da
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos de neuro-psiquiatria (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000400010
• topic: epilepsy; P50 auditory evoked potential; schizophrenia; sensory filter

OBJECTIVE: To identify P50 suppression in patients with epilepsy, to investigate the effect of seizure control on P50 suppression, and to compare epilepsy patients with individuals with schizophrenia and healthy volunteers. METHOD: P50 evoked potential parameters and P50 suppression were studied crossectionally in patients with uncontrolled or controlled epilepsy, in individuals with schizophrenia and in healthy volunteers. RESULTS: Individuals with schizophrenia had significantly smaller conditioning stimulus (S1) amplitude, and patients with epilepsy had larger test stimulus (S2) amplitude. Mean S2/S1 ratio was 0.71±0.33 for patients with uncontrolled epilepsy; 0.68±0.36 for patients with controlled epilepsy; 0.96±0.47 for individuals with schizophrenia, and 0.42±0.24 for healthy volunteers. CONCLUSION: The sensory filter of patients with epilepsy is altered, and this alteration is not associated with seizure control. Also, it works differently from the sensory filter of individuals with schizophrenia.