Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in rats
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000200132 |
Resumo: | The effects of tamoxifen (TAM) on anxiety and depression-like behavior in ovariectomized (OVX) and naïve female rats were investigated. The animals were divided into Sham-TAM, OVX-TAM, Sham and OVX groups. Tamoxifen (1 mg/kg) was administered for 4 weeks. In the forced swimming test, the immobility times in the OVX and Sham-TAM groups were higher than in the Sham group. In the open field, the numbers of central crossings in the OVX and Sham-TAM groups were lower than the number in the Sham group, and the number of peripheral crossings in the OVX group was lower than the number in the Sham group. In the elevated plus maze, the numbers of entries to the open arm among the animals in the Sham-TAM and OVX groups were lower than the number in the Sham group, while the number of entries to the open arm in the OVX-TAM group was higher than the number in the OVX group. It was shown that deletion of ovarian hormones induced anxiety and depression-like behavior. Administration of tamoxifen in naïve rats led to anxiety and depression-like behavior that was comparable with the effects of ovarian hormone deletion. It can be suggested that tamoxifen antagonizes the effects of ovarian hormones. It also seems that tamoxifen has anxiolytic effects on ovariectomized rats. |
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Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in ratsratovariectomizedtamoxifendepressionforced swimming testopen fieldelevated plus mazeThe effects of tamoxifen (TAM) on anxiety and depression-like behavior in ovariectomized (OVX) and naïve female rats were investigated. The animals were divided into Sham-TAM, OVX-TAM, Sham and OVX groups. Tamoxifen (1 mg/kg) was administered for 4 weeks. In the forced swimming test, the immobility times in the OVX and Sham-TAM groups were higher than in the Sham group. In the open field, the numbers of central crossings in the OVX and Sham-TAM groups were lower than the number in the Sham group, and the number of peripheral crossings in the OVX group was lower than the number in the Sham group. In the elevated plus maze, the numbers of entries to the open arm among the animals in the Sham-TAM and OVX groups were lower than the number in the Sham group, while the number of entries to the open arm in the OVX-TAM group was higher than the number in the OVX group. It was shown that deletion of ovarian hormones induced anxiety and depression-like behavior. Administration of tamoxifen in naïve rats led to anxiety and depression-like behavior that was comparable with the effects of ovarian hormone deletion. It can be suggested that tamoxifen antagonizes the effects of ovarian hormones. It also seems that tamoxifen has anxiolytic effects on ovariectomized rats.Academia Brasileira de Neurologia - ABNEURO2015-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000200132Arquivos de Neuro-Psiquiatria v.73 n.2 2015reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20140221info:eu-repo/semantics/openAccessAzizi-Malekabadi,HamidPourganji,MasoumeZabihi,HodaSaeedjalali,MohsenHosseini,Mahmoudeng2015-02-23T00:00:00Zoai:scielo:S0004-282X2015000200132Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2015-02-23T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in rats |
title |
Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in rats |
spellingShingle |
Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in rats Azizi-Malekabadi,Hamid rat ovariectomized tamoxifen depression forced swimming test open field elevated plus maze |
title_short |
Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in rats |
title_full |
Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in rats |
title_fullStr |
Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in rats |
title_full_unstemmed |
Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in rats |
title_sort |
Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in rats |
author |
Azizi-Malekabadi,Hamid |
author_facet |
Azizi-Malekabadi,Hamid Pourganji,Masoume Zabihi,Hoda Saeedjalali,Mohsen Hosseini,Mahmoud |
author_role |
author |
author2 |
Pourganji,Masoume Zabihi,Hoda Saeedjalali,Mohsen Hosseini,Mahmoud |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Azizi-Malekabadi,Hamid Pourganji,Masoume Zabihi,Hoda Saeedjalali,Mohsen Hosseini,Mahmoud |
dc.subject.por.fl_str_mv |
rat ovariectomized tamoxifen depression forced swimming test open field elevated plus maze |
topic |
rat ovariectomized tamoxifen depression forced swimming test open field elevated plus maze |
description |
The effects of tamoxifen (TAM) on anxiety and depression-like behavior in ovariectomized (OVX) and naïve female rats were investigated. The animals were divided into Sham-TAM, OVX-TAM, Sham and OVX groups. Tamoxifen (1 mg/kg) was administered for 4 weeks. In the forced swimming test, the immobility times in the OVX and Sham-TAM groups were higher than in the Sham group. In the open field, the numbers of central crossings in the OVX and Sham-TAM groups were lower than the number in the Sham group, and the number of peripheral crossings in the OVX group was lower than the number in the Sham group. In the elevated plus maze, the numbers of entries to the open arm among the animals in the Sham-TAM and OVX groups were lower than the number in the Sham group, while the number of entries to the open arm in the OVX-TAM group was higher than the number in the OVX group. It was shown that deletion of ovarian hormones induced anxiety and depression-like behavior. Administration of tamoxifen in naïve rats led to anxiety and depression-like behavior that was comparable with the effects of ovarian hormone deletion. It can be suggested that tamoxifen antagonizes the effects of ovarian hormones. It also seems that tamoxifen has anxiolytic effects on ovariectomized rats. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000200132 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000200132 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282X20140221 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.73 n.2 2015 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212777804693504 |