Topiramate and severe metabolic acidosis: case report

Detalhes bibliográficos
Autor(a) principal: Burmeister,Jayme E.
Data de Publicação: 2005
Outros Autores: Pereira,Rafael R., Hartke,Elisa M., Kreuz,Michele
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2005000300032
Resumo: Topiramate infrequently induces anion gap metabolic acidosis through carbonic anhydrase inhibition on the distal tubule of the nephron - a type 2 renal tubular acidosis. We report on a 40 years old woman previously healthy that developed significant asymptomatic metabolic acidosis during topiramate therapy at a dosage of 100mg/day for three months. Stopping medication was followed by normalization of the acid-base status within five weeks. This infrequent side effect appears unpredictable and should be given careful attention.
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spelling Topiramate and severe metabolic acidosis: case reporttopiramatemetabolic acidosiscarbonic anhydrase inhibitorTopiramate infrequently induces anion gap metabolic acidosis through carbonic anhydrase inhibition on the distal tubule of the nephron - a type 2 renal tubular acidosis. We report on a 40 years old woman previously healthy that developed significant asymptomatic metabolic acidosis during topiramate therapy at a dosage of 100mg/day for three months. Stopping medication was followed by normalization of the acid-base status within five weeks. This infrequent side effect appears unpredictable and should be given careful attention.Academia Brasileira de Neurologia - ABNEURO2005-06-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2005000300032Arquivos de Neuro-Psiquiatria v.63 n.2b 2005reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2005000300032info:eu-repo/semantics/openAccessBurmeister,Jayme E.Pereira,Rafael R.Hartke,Elisa M.Kreuz,Micheleeng2005-07-25T00:00:00Zoai:scielo:S0004-282X2005000300032Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2005-07-25T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Topiramate and severe metabolic acidosis: case report
title Topiramate and severe metabolic acidosis: case report
spellingShingle Topiramate and severe metabolic acidosis: case report
Burmeister,Jayme E.
topiramate
metabolic acidosis
carbonic anhydrase inhibitor
title_short Topiramate and severe metabolic acidosis: case report
title_full Topiramate and severe metabolic acidosis: case report
title_fullStr Topiramate and severe metabolic acidosis: case report
title_full_unstemmed Topiramate and severe metabolic acidosis: case report
title_sort Topiramate and severe metabolic acidosis: case report
author Burmeister,Jayme E.
author_facet Burmeister,Jayme E.
Pereira,Rafael R.
Hartke,Elisa M.
Kreuz,Michele
author_role author
author2 Pereira,Rafael R.
Hartke,Elisa M.
Kreuz,Michele
author2_role author
author
author
dc.contributor.author.fl_str_mv Burmeister,Jayme E.
Pereira,Rafael R.
Hartke,Elisa M.
Kreuz,Michele
dc.subject.por.fl_str_mv topiramate
metabolic acidosis
carbonic anhydrase inhibitor
topic topiramate
metabolic acidosis
carbonic anhydrase inhibitor
description Topiramate infrequently induces anion gap metabolic acidosis through carbonic anhydrase inhibition on the distal tubule of the nephron - a type 2 renal tubular acidosis. We report on a 40 years old woman previously healthy that developed significant asymptomatic metabolic acidosis during topiramate therapy at a dosage of 100mg/day for three months. Stopping medication was followed by normalization of the acid-base status within five weeks. This infrequent side effect appears unpredictable and should be given careful attention.
publishDate 2005
dc.date.none.fl_str_mv 2005-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2005000300032
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2005000300032
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2005000300032
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.63 n.2b 2005
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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