Developmental milestones of vertically HIV infected and seroreverters children: follow up of 83 children

Detalhes bibliográficos
Autor(a) principal: Bruck,Isac
Data de Publicação: 2001
Outros Autores: Tahan,Tony Tannous, Cruz,Cristina Rodrigues da, Martins,Luzilma Terezinha Flenik, Antoniuk,Sérgio Antonio, Rodrigues,Marcelo, Souza,Sílvia Mara de, Bruyn,Laís Regina de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2001000500007
Resumo: The aim of the study was to detect neurological abnormalities in human immunodeficiency virus (HIV) infected children. This was achieved by a prospective evaluation, from November/1995 to April/2000, of 43 HIV infected children (group I) and 40 HIV seroreverters children (group II) through neurological exam and neurodevelopmental tests: Denver Developmental Screening Test (DDST) and Clinical Adaptive Test / Clinical Linguistic and Auditory Milestone Scale (CAT/CLAMS). A control group (III), of 67 children, were evaluated by CAT/CLAMS. Hyperactivity, irritability and hypotonia were the findings on neurological examination, without statistical differences between group I and II. On CAT/CLAMS, the group I developmental quotient (DQ) was significantly lower than the other groups. The same occurred in DDST, with group I presenting significantly more failures than group II. Nineteen HIV children of group I had brain computed tomographic scan, with abnormalities in three of them (basal ganglia calcification, white matter hypodensity and asymmetry of lateral ventricles). We conclude that in HIV infected children a neurodevelopment delay occur early in the disease, and it can be detected by screening tests.
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spelling Developmental milestones of vertically HIV infected and seroreverters children: follow up of 83 childrenhuman immunodeficiency virus (HIV)neurodevelopment delayneurological screening testThe aim of the study was to detect neurological abnormalities in human immunodeficiency virus (HIV) infected children. This was achieved by a prospective evaluation, from November/1995 to April/2000, of 43 HIV infected children (group I) and 40 HIV seroreverters children (group II) through neurological exam and neurodevelopmental tests: Denver Developmental Screening Test (DDST) and Clinical Adaptive Test / Clinical Linguistic and Auditory Milestone Scale (CAT/CLAMS). A control group (III), of 67 children, were evaluated by CAT/CLAMS. Hyperactivity, irritability and hypotonia were the findings on neurological examination, without statistical differences between group I and II. On CAT/CLAMS, the group I developmental quotient (DQ) was significantly lower than the other groups. The same occurred in DDST, with group I presenting significantly more failures than group II. Nineteen HIV children of group I had brain computed tomographic scan, with abnormalities in three of them (basal ganglia calcification, white matter hypodensity and asymmetry of lateral ventricles). We conclude that in HIV infected children a neurodevelopment delay occur early in the disease, and it can be detected by screening tests.Academia Brasileira de Neurologia - ABNEURO2001-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2001000500007Arquivos de Neuro-Psiquiatria v.59 n.3B 2001reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2001000500007info:eu-repo/semantics/openAccessBruck,IsacTahan,Tony TannousCruz,Cristina Rodrigues daMartins,Luzilma Terezinha FlenikAntoniuk,Sérgio AntonioRodrigues,MarceloSouza,Sílvia Mara deBruyn,Laís Regina deeng2001-10-05T00:00:00Zoai:scielo:S0004-282X2001000500007Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2001-10-05T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Developmental milestones of vertically HIV infected and seroreverters children: follow up of 83 children
title Developmental milestones of vertically HIV infected and seroreverters children: follow up of 83 children
spellingShingle Developmental milestones of vertically HIV infected and seroreverters children: follow up of 83 children
Bruck,Isac
human immunodeficiency virus (HIV)
neurodevelopment delay
neurological screening test
title_short Developmental milestones of vertically HIV infected and seroreverters children: follow up of 83 children
title_full Developmental milestones of vertically HIV infected and seroreverters children: follow up of 83 children
title_fullStr Developmental milestones of vertically HIV infected and seroreverters children: follow up of 83 children
title_full_unstemmed Developmental milestones of vertically HIV infected and seroreverters children: follow up of 83 children
title_sort Developmental milestones of vertically HIV infected and seroreverters children: follow up of 83 children
author Bruck,Isac
author_facet Bruck,Isac
Tahan,Tony Tannous
Cruz,Cristina Rodrigues da
Martins,Luzilma Terezinha Flenik
Antoniuk,Sérgio Antonio
Rodrigues,Marcelo
Souza,Sílvia Mara de
Bruyn,Laís Regina de
author_role author
author2 Tahan,Tony Tannous
Cruz,Cristina Rodrigues da
Martins,Luzilma Terezinha Flenik
Antoniuk,Sérgio Antonio
Rodrigues,Marcelo
Souza,Sílvia Mara de
Bruyn,Laís Regina de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bruck,Isac
Tahan,Tony Tannous
Cruz,Cristina Rodrigues da
Martins,Luzilma Terezinha Flenik
Antoniuk,Sérgio Antonio
Rodrigues,Marcelo
Souza,Sílvia Mara de
Bruyn,Laís Regina de
dc.subject.por.fl_str_mv human immunodeficiency virus (HIV)
neurodevelopment delay
neurological screening test
topic human immunodeficiency virus (HIV)
neurodevelopment delay
neurological screening test
description The aim of the study was to detect neurological abnormalities in human immunodeficiency virus (HIV) infected children. This was achieved by a prospective evaluation, from November/1995 to April/2000, of 43 HIV infected children (group I) and 40 HIV seroreverters children (group II) through neurological exam and neurodevelopmental tests: Denver Developmental Screening Test (DDST) and Clinical Adaptive Test / Clinical Linguistic and Auditory Milestone Scale (CAT/CLAMS). A control group (III), of 67 children, were evaluated by CAT/CLAMS. Hyperactivity, irritability and hypotonia were the findings on neurological examination, without statistical differences between group I and II. On CAT/CLAMS, the group I developmental quotient (DQ) was significantly lower than the other groups. The same occurred in DDST, with group I presenting significantly more failures than group II. Nineteen HIV children of group I had brain computed tomographic scan, with abnormalities in three of them (basal ganglia calcification, white matter hypodensity and asymmetry of lateral ventricles). We conclude that in HIV infected children a neurodevelopment delay occur early in the disease, and it can be detected by screening tests.
publishDate 2001
dc.date.none.fl_str_mv 2001-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2001000500007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2001000500007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2001000500007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.59 n.3B 2001
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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