Anti-epileptic drug intake adherence: the value of the blood drug level measurement and the clinical approach

Detalhes bibliográficos
Autor(a) principal: GOMES,MARLEIDE DA MOTA
Data de Publicação: 1998
Outros Autores: MAIA FILHO,HEBER DE SOUZA, NOÉ,ROSÂNGELA APARECIDA MARTINS
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1998000500002
Resumo: It was evaluated the patient antiepileptic drug (AED) intake adherence in a pilot cross-sectional study carried out at a neurologic out-patient clinic of a university hospital. Ninety-three AED blood concentration (phenobarbital, phenytoin, carbamazepine) were analyzed from 24 patients. The variability of the AED blood level was measured (in the steady state period by means of the variation coefficient) and compared with the self-reported antiepileptic medication non-adherence, AED blood level according to the range (therapeutic or not), and the seizure control. It was not observed any strong correlation between the higher value of variability and the other three parameters of no adherence. The highest correlation was with the blood drug level (therapeutic or not). The evaluation of blood drug measurement alone, except in cases of extreme low adherence and variability of drug intake, is not enough for the recognition of incorrect drug intake, but the clinical markers and the self-reported adherence have to be also considered for this sort of evaluation.
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spelling Anti-epileptic drug intake adherence: the value of the blood drug level measurement and the clinical approachepilepsyadherencetherapeutic blood monitoringantiepileptic drugsIt was evaluated the patient antiepileptic drug (AED) intake adherence in a pilot cross-sectional study carried out at a neurologic out-patient clinic of a university hospital. Ninety-three AED blood concentration (phenobarbital, phenytoin, carbamazepine) were analyzed from 24 patients. The variability of the AED blood level was measured (in the steady state period by means of the variation coefficient) and compared with the self-reported antiepileptic medication non-adherence, AED blood level according to the range (therapeutic or not), and the seizure control. It was not observed any strong correlation between the higher value of variability and the other three parameters of no adherence. The highest correlation was with the blood drug level (therapeutic or not). The evaluation of blood drug measurement alone, except in cases of extreme low adherence and variability of drug intake, is not enough for the recognition of incorrect drug intake, but the clinical markers and the self-reported adherence have to be also considered for this sort of evaluation.Academia Brasileira de Neurologia - ABNEURO1998-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1998000500002Arquivos de Neuro-Psiquiatria v.56 n.4 1998reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X1998000500002info:eu-repo/semantics/openAccessGOMES,MARLEIDE DA MOTAMAIA FILHO,HEBER DE SOUZANOÉ,ROSÂNGELA APARECIDA MARTINSeng2000-11-06T00:00:00Zoai:scielo:S0004-282X1998000500002Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2000-11-06T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Anti-epileptic drug intake adherence: the value of the blood drug level measurement and the clinical approach
title Anti-epileptic drug intake adherence: the value of the blood drug level measurement and the clinical approach
spellingShingle Anti-epileptic drug intake adherence: the value of the blood drug level measurement and the clinical approach
GOMES,MARLEIDE DA MOTA
epilepsy
adherence
therapeutic blood monitoring
antiepileptic drugs
title_short Anti-epileptic drug intake adherence: the value of the blood drug level measurement and the clinical approach
title_full Anti-epileptic drug intake adherence: the value of the blood drug level measurement and the clinical approach
title_fullStr Anti-epileptic drug intake adherence: the value of the blood drug level measurement and the clinical approach
title_full_unstemmed Anti-epileptic drug intake adherence: the value of the blood drug level measurement and the clinical approach
title_sort Anti-epileptic drug intake adherence: the value of the blood drug level measurement and the clinical approach
author GOMES,MARLEIDE DA MOTA
author_facet GOMES,MARLEIDE DA MOTA
MAIA FILHO,HEBER DE SOUZA
NOÉ,ROSÂNGELA APARECIDA MARTINS
author_role author
author2 MAIA FILHO,HEBER DE SOUZA
NOÉ,ROSÂNGELA APARECIDA MARTINS
author2_role author
author
dc.contributor.author.fl_str_mv GOMES,MARLEIDE DA MOTA
MAIA FILHO,HEBER DE SOUZA
NOÉ,ROSÂNGELA APARECIDA MARTINS
dc.subject.por.fl_str_mv epilepsy
adherence
therapeutic blood monitoring
antiepileptic drugs
topic epilepsy
adherence
therapeutic blood monitoring
antiepileptic drugs
description It was evaluated the patient antiepileptic drug (AED) intake adherence in a pilot cross-sectional study carried out at a neurologic out-patient clinic of a university hospital. Ninety-three AED blood concentration (phenobarbital, phenytoin, carbamazepine) were analyzed from 24 patients. The variability of the AED blood level was measured (in the steady state period by means of the variation coefficient) and compared with the self-reported antiepileptic medication non-adherence, AED blood level according to the range (therapeutic or not), and the seizure control. It was not observed any strong correlation between the higher value of variability and the other three parameters of no adherence. The highest correlation was with the blood drug level (therapeutic or not). The evaluation of blood drug measurement alone, except in cases of extreme low adherence and variability of drug intake, is not enough for the recognition of incorrect drug intake, but the clinical markers and the self-reported adherence have to be also considered for this sort of evaluation.
publishDate 1998
dc.date.none.fl_str_mv 1998-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1998000500002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1998000500002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X1998000500002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.56 n.4 1998
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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