Quantification of cerebrospinal fluid ferritin as a biomarker for CNS malignant infiltration

• Autor(a) principal: Almeida,Sérgio Monteiro de
• Data de Publicação: 2008
• Outros Autores: Cunha,Dione Sosnitzki da, Yamada,Edna, Doi,Elvira Missako, Ono,Margaret
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos de neuro-psiquiatria (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000500022
• topic: cerebrospinal fluid; ferritin; central nervous system; malignant cells; CNS neoplasm; CNS tumors; bacterial meningitis

Several markers have been studied for their ability to make the CNS infiltration diagnosis earlier and more precise; previous studies showed that CSF ferritin concentrations were higher in patients with malignant invasion of CNS. The objective was to determine the importance of CSF ferritin as a biomarker for the diagnosis of CNS neoplasic infiltration. This study is based on 93 CSF samples, divided into five groups: malignant cells present (n13); malignant cells not present (n26); inflammatory neurological diseases (n16); neurocysticercosis (n20); acute bacterial meningitis (n18). CSF ferritin values were determined by micro particle enzyme immunoassay. CSF ferritin level (mean±SD) in the group with neoplasic cells in the CSF was 42.8±49.7 ng /mL, higher than in the other groups (p<0.0001). We conclude that CSF ferritin with the cut off 20 ng/mL could be an adjuvant biomarker to the diagnosis of CNS malignant infiltration.