Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injury

Detalhes bibliográficos
Autor(a) principal: Grassi,Daphine Centola
Data de Publicação: 2022
Outros Autores: Zaninotto,Ana Luiza, Feltrin,Fabrício Stewan, Macruz,Fabíola Bezerra de Carvalho, Otaduy,Maria Concepción García, Leite,Claudia da Costa, Guirado,Vinicius Monteiro de Paula, Paiva,Wellingson Silva, Andrade,Celi Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000300280
Resumo: ABSTRACT Background: Diffuse axonal injury occurs with high acceleration and deceleration forces in traumatic brain injury (TBI). This lesion leads to disarrangement of the neuronal network, which can result in some degree of deficiency. The Extended Glasgow Outcome Scale (GOS-E) is the primary outcome instrument for the evaluation of TBI victims. Diffusion tensor imaging (DTI) assesses white matter (WM) microstructure based on the displacement distribution of water molecules. Objective: To investigate WM microstructure within the first year after TBI using DTI, the patient’s clinical outcomes, and associations. Methods: We scanned 20 moderate and severe TBI victims at 2 months and 1 year after the event. Imaging processing was done with the FMRIB software library; we used the tract-based spatial statistics software yielding fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) for statistical analyses. We computed the average difference between the two measures across subjects and performed a one-sample t-test and threshold-free cluster enhancement, using a corrected p-value < 0.05. Clinical outcomes were evaluated with the GOS-E. We tested for associations between outcome measures and significant mean FA clusters. Results: Significant clusters of altered FA were identified anatomically using the JHU WM atlas. We found increasing spotted areas of FA with time in the right brain hemisphere and left cerebellum. Extensive regions of increased MD, RD, and AD were observed. Patients presented an excellent overall recovery. Conclusions: There were no associations between FA and outcome scores, but we cannot exclude the existence of a small to moderate association.
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spelling Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injuryCraniocerebral TraumaDiffuse Axonal InjuryDiffusion Tensor ImagingGlasgow Outcome ScaleRegenerationABSTRACT Background: Diffuse axonal injury occurs with high acceleration and deceleration forces in traumatic brain injury (TBI). This lesion leads to disarrangement of the neuronal network, which can result in some degree of deficiency. The Extended Glasgow Outcome Scale (GOS-E) is the primary outcome instrument for the evaluation of TBI victims. Diffusion tensor imaging (DTI) assesses white matter (WM) microstructure based on the displacement distribution of water molecules. Objective: To investigate WM microstructure within the first year after TBI using DTI, the patient’s clinical outcomes, and associations. Methods: We scanned 20 moderate and severe TBI victims at 2 months and 1 year after the event. Imaging processing was done with the FMRIB software library; we used the tract-based spatial statistics software yielding fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) for statistical analyses. We computed the average difference between the two measures across subjects and performed a one-sample t-test and threshold-free cluster enhancement, using a corrected p-value < 0.05. Clinical outcomes were evaluated with the GOS-E. We tested for associations between outcome measures and significant mean FA clusters. Results: Significant clusters of altered FA were identified anatomically using the JHU WM atlas. We found increasing spotted areas of FA with time in the right brain hemisphere and left cerebellum. Extensive regions of increased MD, RD, and AD were observed. Patients presented an excellent overall recovery. Conclusions: There were no associations between FA and outcome scores, but we cannot exclude the existence of a small to moderate association.Academia Brasileira de Neurologia - ABNEURO2022-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000300280Arquivos de Neuro-Psiquiatria v.80 n.3 2022reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x-anp-2020-0595info:eu-repo/semantics/openAccessGrassi,Daphine CentolaZaninotto,Ana LuizaFeltrin,Fabrício StewanMacruz,Fabíola Bezerra de CarvalhoOtaduy,Maria Concepción GarcíaLeite,Claudia da CostaGuirado,Vinicius Monteiro de PaulaPaiva,Wellingson SilvaAndrade,Celi Santoseng2022-04-04T00:00:00Zoai:scielo:S0004-282X2022000300280Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2022-04-04T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injury
title Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injury
spellingShingle Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injury
Grassi,Daphine Centola
Craniocerebral Trauma
Diffuse Axonal Injury
Diffusion Tensor Imaging
Glasgow Outcome Scale
Regeneration
title_short Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injury
title_full Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injury
title_fullStr Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injury
title_full_unstemmed Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injury
title_sort Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injury
author Grassi,Daphine Centola
author_facet Grassi,Daphine Centola
Zaninotto,Ana Luiza
Feltrin,Fabrício Stewan
Macruz,Fabíola Bezerra de Carvalho
Otaduy,Maria Concepción García
Leite,Claudia da Costa
Guirado,Vinicius Monteiro de Paula
Paiva,Wellingson Silva
Andrade,Celi Santos
author_role author
author2 Zaninotto,Ana Luiza
Feltrin,Fabrício Stewan
Macruz,Fabíola Bezerra de Carvalho
Otaduy,Maria Concepción García
Leite,Claudia da Costa
Guirado,Vinicius Monteiro de Paula
Paiva,Wellingson Silva
Andrade,Celi Santos
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Grassi,Daphine Centola
Zaninotto,Ana Luiza
Feltrin,Fabrício Stewan
Macruz,Fabíola Bezerra de Carvalho
Otaduy,Maria Concepción García
Leite,Claudia da Costa
Guirado,Vinicius Monteiro de Paula
Paiva,Wellingson Silva
Andrade,Celi Santos
dc.subject.por.fl_str_mv Craniocerebral Trauma
Diffuse Axonal Injury
Diffusion Tensor Imaging
Glasgow Outcome Scale
Regeneration
topic Craniocerebral Trauma
Diffuse Axonal Injury
Diffusion Tensor Imaging
Glasgow Outcome Scale
Regeneration
description ABSTRACT Background: Diffuse axonal injury occurs with high acceleration and deceleration forces in traumatic brain injury (TBI). This lesion leads to disarrangement of the neuronal network, which can result in some degree of deficiency. The Extended Glasgow Outcome Scale (GOS-E) is the primary outcome instrument for the evaluation of TBI victims. Diffusion tensor imaging (DTI) assesses white matter (WM) microstructure based on the displacement distribution of water molecules. Objective: To investigate WM microstructure within the first year after TBI using DTI, the patient’s clinical outcomes, and associations. Methods: We scanned 20 moderate and severe TBI victims at 2 months and 1 year after the event. Imaging processing was done with the FMRIB software library; we used the tract-based spatial statistics software yielding fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) for statistical analyses. We computed the average difference between the two measures across subjects and performed a one-sample t-test and threshold-free cluster enhancement, using a corrected p-value < 0.05. Clinical outcomes were evaluated with the GOS-E. We tested for associations between outcome measures and significant mean FA clusters. Results: Significant clusters of altered FA were identified anatomically using the JHU WM atlas. We found increasing spotted areas of FA with time in the right brain hemisphere and left cerebellum. Extensive regions of increased MD, RD, and AD were observed. Patients presented an excellent overall recovery. Conclusions: There were no associations between FA and outcome scores, but we cannot exclude the existence of a small to moderate association.
publishDate 2022
dc.date.none.fl_str_mv 2022-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000300280
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282x-anp-2020-0595
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.80 n.3 2022
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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