Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injury
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000300280 |
Resumo: | ABSTRACT Background: Diffuse axonal injury occurs with high acceleration and deceleration forces in traumatic brain injury (TBI). This lesion leads to disarrangement of the neuronal network, which can result in some degree of deficiency. The Extended Glasgow Outcome Scale (GOS-E) is the primary outcome instrument for the evaluation of TBI victims. Diffusion tensor imaging (DTI) assesses white matter (WM) microstructure based on the displacement distribution of water molecules. Objective: To investigate WM microstructure within the first year after TBI using DTI, the patient’s clinical outcomes, and associations. Methods: We scanned 20 moderate and severe TBI victims at 2 months and 1 year after the event. Imaging processing was done with the FMRIB software library; we used the tract-based spatial statistics software yielding fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) for statistical analyses. We computed the average difference between the two measures across subjects and performed a one-sample t-test and threshold-free cluster enhancement, using a corrected p-value < 0.05. Clinical outcomes were evaluated with the GOS-E. We tested for associations between outcome measures and significant mean FA clusters. Results: Significant clusters of altered FA were identified anatomically using the JHU WM atlas. We found increasing spotted areas of FA with time in the right brain hemisphere and left cerebellum. Extensive regions of increased MD, RD, and AD were observed. Patients presented an excellent overall recovery. Conclusions: There were no associations between FA and outcome scores, but we cannot exclude the existence of a small to moderate association. |
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Arquivos de neuro-psiquiatria (Online) |
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Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injuryCraniocerebral TraumaDiffuse Axonal InjuryDiffusion Tensor ImagingGlasgow Outcome ScaleRegenerationABSTRACT Background: Diffuse axonal injury occurs with high acceleration and deceleration forces in traumatic brain injury (TBI). This lesion leads to disarrangement of the neuronal network, which can result in some degree of deficiency. The Extended Glasgow Outcome Scale (GOS-E) is the primary outcome instrument for the evaluation of TBI victims. Diffusion tensor imaging (DTI) assesses white matter (WM) microstructure based on the displacement distribution of water molecules. Objective: To investigate WM microstructure within the first year after TBI using DTI, the patient’s clinical outcomes, and associations. Methods: We scanned 20 moderate and severe TBI victims at 2 months and 1 year after the event. Imaging processing was done with the FMRIB software library; we used the tract-based spatial statistics software yielding fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) for statistical analyses. We computed the average difference between the two measures across subjects and performed a one-sample t-test and threshold-free cluster enhancement, using a corrected p-value < 0.05. Clinical outcomes were evaluated with the GOS-E. We tested for associations between outcome measures and significant mean FA clusters. Results: Significant clusters of altered FA were identified anatomically using the JHU WM atlas. We found increasing spotted areas of FA with time in the right brain hemisphere and left cerebellum. Extensive regions of increased MD, RD, and AD were observed. Patients presented an excellent overall recovery. Conclusions: There were no associations between FA and outcome scores, but we cannot exclude the existence of a small to moderate association.Academia Brasileira de Neurologia - ABNEURO2022-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000300280Arquivos de Neuro-Psiquiatria v.80 n.3 2022reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x-anp-2020-0595info:eu-repo/semantics/openAccessGrassi,Daphine CentolaZaninotto,Ana LuizaFeltrin,Fabrício StewanMacruz,Fabíola Bezerra de CarvalhoOtaduy,Maria Concepción GarcíaLeite,Claudia da CostaGuirado,Vinicius Monteiro de PaulaPaiva,Wellingson SilvaAndrade,Celi Santoseng2022-04-04T00:00:00Zoai:scielo:S0004-282X2022000300280Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2022-04-04T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injury |
title |
Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injury |
spellingShingle |
Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injury Grassi,Daphine Centola Craniocerebral Trauma Diffuse Axonal Injury Diffusion Tensor Imaging Glasgow Outcome Scale Regeneration |
title_short |
Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injury |
title_full |
Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injury |
title_fullStr |
Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injury |
title_full_unstemmed |
Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injury |
title_sort |
Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injury |
author |
Grassi,Daphine Centola |
author_facet |
Grassi,Daphine Centola Zaninotto,Ana Luiza Feltrin,Fabrício Stewan Macruz,Fabíola Bezerra de Carvalho Otaduy,Maria Concepción García Leite,Claudia da Costa Guirado,Vinicius Monteiro de Paula Paiva,Wellingson Silva Andrade,Celi Santos |
author_role |
author |
author2 |
Zaninotto,Ana Luiza Feltrin,Fabrício Stewan Macruz,Fabíola Bezerra de Carvalho Otaduy,Maria Concepción García Leite,Claudia da Costa Guirado,Vinicius Monteiro de Paula Paiva,Wellingson Silva Andrade,Celi Santos |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Grassi,Daphine Centola Zaninotto,Ana Luiza Feltrin,Fabrício Stewan Macruz,Fabíola Bezerra de Carvalho Otaduy,Maria Concepción García Leite,Claudia da Costa Guirado,Vinicius Monteiro de Paula Paiva,Wellingson Silva Andrade,Celi Santos |
dc.subject.por.fl_str_mv |
Craniocerebral Trauma Diffuse Axonal Injury Diffusion Tensor Imaging Glasgow Outcome Scale Regeneration |
topic |
Craniocerebral Trauma Diffuse Axonal Injury Diffusion Tensor Imaging Glasgow Outcome Scale Regeneration |
description |
ABSTRACT Background: Diffuse axonal injury occurs with high acceleration and deceleration forces in traumatic brain injury (TBI). This lesion leads to disarrangement of the neuronal network, which can result in some degree of deficiency. The Extended Glasgow Outcome Scale (GOS-E) is the primary outcome instrument for the evaluation of TBI victims. Diffusion tensor imaging (DTI) assesses white matter (WM) microstructure based on the displacement distribution of water molecules. Objective: To investigate WM microstructure within the first year after TBI using DTI, the patient’s clinical outcomes, and associations. Methods: We scanned 20 moderate and severe TBI victims at 2 months and 1 year after the event. Imaging processing was done with the FMRIB software library; we used the tract-based spatial statistics software yielding fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) for statistical analyses. We computed the average difference between the two measures across subjects and performed a one-sample t-test and threshold-free cluster enhancement, using a corrected p-value < 0.05. Clinical outcomes were evaluated with the GOS-E. We tested for associations between outcome measures and significant mean FA clusters. Results: Significant clusters of altered FA were identified anatomically using the JHU WM atlas. We found increasing spotted areas of FA with time in the right brain hemisphere and left cerebellum. Extensive regions of increased MD, RD, and AD were observed. Patients presented an excellent overall recovery. Conclusions: There were no associations between FA and outcome scores, but we cannot exclude the existence of a small to moderate association. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000300280 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000300280 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282x-anp-2020-0595 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.80 n.3 2022 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
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