White matter hyperintensities, executive function and global cognitive performance in vascular mild cognitive impairment

• Autor(a) principal: Sudo,Felipe Kenji
• Data de Publicação: 2013
• Outros Autores: Alves,Carlos Eduardo Oliveira, Alves,Gilberto Sousa, Ericeira-Valente,Letice, Tiel,Chan, Moreira,Denise Madeira, Laks,Jerson, Engelhardt,Eliasz
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos de neuro-psiquiatria (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000700431
• topic: mild cognitive impairment; dementia; vascular; executive function; neuropsychology; neuroimaging; cerebrovascular disorders

Vascular mild cognitive impairment (VaMCI) represents an early symptomatic stage of vascular cognitive impairment and might be associated to fronto-executive dysfunction.MethodsTwenty-six individuals (age: 73.11±7.90 years; 65.4% female; schooling: 9.84±3.61 years) were selected through neuropsychological assessment and neuroimaging. Clinical and neuroimaging data of VaMCI individuals (n=15) were compared to normal controls (NC, n=11) and correlated with Fazekas scale.ResultsVaMCI performed significantly worse than NC in Trail-Making Test (TMT) B, errors in TMT B, difference TMT B-A and Cambridge Cognitive Examination (CAMCOG) final scores. Correlations were found among scores in modified Fazekas scale and performances in TMT B (time to complete and errors), difference TMT B-A and CAMCOG total score.ConclusionExtension of white matter hyperintensities might be correlated to poorer global cognition and impairments in a set of fronto-executive functions, such as cognitive speed, set shifting and inhibitory control in VaMCI.