A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluation
Autor(a) principal: | |
---|---|
Data de Publicação: | 2003 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500007 |
Resumo: | Oxidative stress causes metabolic and structural abnormalities during reperfusion. In an animal model of electrophysiological evaluation of cerebral ischemia-reperfusion, alpha-lipoic acid effect on the oxidative stress was studied by mean absolute amplitude of EEG spectra evaluation. The left carotideal infusion of 3.03 mM alpha-lipoic acid in Wistar rats after cerebral ischemia and reperfusion caused initial reduction and partial final recuperation of the various EEG spectral frequency mean absolute amplitudes (p<0.05). The left intracarotideal infusion of 6.06 mM alpha-lipoic acid significantly reverted the induced depression of mean absolute amplitude of theta and delta spectra. Nevertheless there was an increasing pattern of ischemia demonstrated by mean absolute amplitude depression of almost all EEG spectra with 60.6 mM alpha-lipoic acid infusion. These observations suggest that, depending on the administered concentration, alpha-lipoic acid may act in a dual way, protecting from ischemia at lower concentrations and worsening this process at higher doses. |
id |
ABNEURO-1_722bbea3f947584075529009a731fff3 |
---|---|
oai_identifier_str |
oai:scielo:S0004-282X2003000500007 |
network_acronym_str |
ABNEURO-1 |
network_name_str |
Arquivos de neuro-psiquiatria (Online) |
repository_id_str |
|
spelling |
A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluationalpha-lipoic acidanti-oxidantpro-oxidantcerebral ischemiaelectroencephalogram (EEG)spectral mean absolute amplitudeOxidative stress causes metabolic and structural abnormalities during reperfusion. In an animal model of electrophysiological evaluation of cerebral ischemia-reperfusion, alpha-lipoic acid effect on the oxidative stress was studied by mean absolute amplitude of EEG spectra evaluation. The left carotideal infusion of 3.03 mM alpha-lipoic acid in Wistar rats after cerebral ischemia and reperfusion caused initial reduction and partial final recuperation of the various EEG spectral frequency mean absolute amplitudes (p<0.05). The left intracarotideal infusion of 6.06 mM alpha-lipoic acid significantly reverted the induced depression of mean absolute amplitude of theta and delta spectra. Nevertheless there was an increasing pattern of ischemia demonstrated by mean absolute amplitude depression of almost all EEG spectra with 60.6 mM alpha-lipoic acid infusion. These observations suggest that, depending on the administered concentration, alpha-lipoic acid may act in a dual way, protecting from ischemia at lower concentrations and worsening this process at higher doses.Academia Brasileira de Neurologia - ABNEURO2003-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500007Arquivos de Neuro-Psiquiatria v.61 n.3B 2003reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2003000500007info:eu-repo/semantics/openAccessVale,Otoni Cardoso doFonteles,Daniel Sá RorizCabral,Francisco RomeroFonteles,Manassés Claudinoeng2003-11-12T00:00:00Zoai:scielo:S0004-282X2003000500007Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2003-11-12T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluation |
title |
A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluation |
spellingShingle |
A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluation Vale,Otoni Cardoso do alpha-lipoic acid anti-oxidant pro-oxidant cerebral ischemia electroencephalogram (EEG) spectral mean absolute amplitude |
title_short |
A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluation |
title_full |
A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluation |
title_fullStr |
A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluation |
title_full_unstemmed |
A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluation |
title_sort |
A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluation |
author |
Vale,Otoni Cardoso do |
author_facet |
Vale,Otoni Cardoso do Fonteles,Daniel Sá Roriz Cabral,Francisco Romero Fonteles,Manassés Claudino |
author_role |
author |
author2 |
Fonteles,Daniel Sá Roriz Cabral,Francisco Romero Fonteles,Manassés Claudino |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Vale,Otoni Cardoso do Fonteles,Daniel Sá Roriz Cabral,Francisco Romero Fonteles,Manassés Claudino |
dc.subject.por.fl_str_mv |
alpha-lipoic acid anti-oxidant pro-oxidant cerebral ischemia electroencephalogram (EEG) spectral mean absolute amplitude |
topic |
alpha-lipoic acid anti-oxidant pro-oxidant cerebral ischemia electroencephalogram (EEG) spectral mean absolute amplitude |
description |
Oxidative stress causes metabolic and structural abnormalities during reperfusion. In an animal model of electrophysiological evaluation of cerebral ischemia-reperfusion, alpha-lipoic acid effect on the oxidative stress was studied by mean absolute amplitude of EEG spectra evaluation. The left carotideal infusion of 3.03 mM alpha-lipoic acid in Wistar rats after cerebral ischemia and reperfusion caused initial reduction and partial final recuperation of the various EEG spectral frequency mean absolute amplitudes (p<0.05). The left intracarotideal infusion of 6.06 mM alpha-lipoic acid significantly reverted the induced depression of mean absolute amplitude of theta and delta spectra. Nevertheless there was an increasing pattern of ischemia demonstrated by mean absolute amplitude depression of almost all EEG spectra with 60.6 mM alpha-lipoic acid infusion. These observations suggest that, depending on the administered concentration, alpha-lipoic acid may act in a dual way, protecting from ischemia at lower concentrations and worsening this process at higher doses. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500007 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2003000500007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.61 n.3B 2003 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
_version_ |
1754212755774111744 |