Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats

Detalhes bibliográficos
Autor(a) principal: Baghcheghi,Yousef
Data de Publicação: 2018
Outros Autores: Hosseini,Mahmoud, Beheshti,Farimah, Salmani,Hossein, Anaeigoudari,Akbar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000100032
Resumo: ABSTRACT In this study, the effect of thymoquinone (TQ) on propylthiouracil (PTU)-induced memory impairment was investigated in juvenile rats. The rats were grouped into control, Hypo, Hypo-TQ5 and Hypo-TQ10. Propylthiouracil increased latency time in the Morris water maze test and decreased delay in entering the dark compartment in the passive avoidance test. Both 5 mg/kg and 10 mg/kg doses of TQ decreased latency time in the Morris water maze test and increased delay in entering the dark compartment in a passive avoidance test. The PTU also increased malondialdehyde and nitric oxide metabolites in the brain while reduced the thiol content and superoxide dismutase and catalase activities and serum T4 level. Both doses of TQ decreased malondialdehyde and nitric oxide metabolites in the brain while enhanced the thiol content and superoxide dismutase and catalase activities and serum T4 level. The results of the present study showed that TQ protected against PTU-induced memory impairments in rats.
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spelling Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile ratshypothyroidismpropylthiouracilmemoryABSTRACT In this study, the effect of thymoquinone (TQ) on propylthiouracil (PTU)-induced memory impairment was investigated in juvenile rats. The rats were grouped into control, Hypo, Hypo-TQ5 and Hypo-TQ10. Propylthiouracil increased latency time in the Morris water maze test and decreased delay in entering the dark compartment in the passive avoidance test. Both 5 mg/kg and 10 mg/kg doses of TQ decreased latency time in the Morris water maze test and increased delay in entering the dark compartment in a passive avoidance test. The PTU also increased malondialdehyde and nitric oxide metabolites in the brain while reduced the thiol content and superoxide dismutase and catalase activities and serum T4 level. Both doses of TQ decreased malondialdehyde and nitric oxide metabolites in the brain while enhanced the thiol content and superoxide dismutase and catalase activities and serum T4 level. The results of the present study showed that TQ protected against PTU-induced memory impairments in rats.Academia Brasileira de Neurologia - ABNEURO2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000100032Arquivos de Neuro-Psiquiatria v.76 n.1 2018reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20170182info:eu-repo/semantics/openAccessBaghcheghi,YousefHosseini,MahmoudBeheshti,FarimahSalmani,HosseinAnaeigoudari,Akbareng2018-01-17T00:00:00Zoai:scielo:S0004-282X2018000100032Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2018-01-17T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats
title Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats
spellingShingle Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats
Baghcheghi,Yousef
hypothyroidism
propylthiouracil
memory
title_short Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats
title_full Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats
title_fullStr Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats
title_full_unstemmed Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats
title_sort Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats
author Baghcheghi,Yousef
author_facet Baghcheghi,Yousef
Hosseini,Mahmoud
Beheshti,Farimah
Salmani,Hossein
Anaeigoudari,Akbar
author_role author
author2 Hosseini,Mahmoud
Beheshti,Farimah
Salmani,Hossein
Anaeigoudari,Akbar
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Baghcheghi,Yousef
Hosseini,Mahmoud
Beheshti,Farimah
Salmani,Hossein
Anaeigoudari,Akbar
dc.subject.por.fl_str_mv hypothyroidism
propylthiouracil
memory
topic hypothyroidism
propylthiouracil
memory
description ABSTRACT In this study, the effect of thymoquinone (TQ) on propylthiouracil (PTU)-induced memory impairment was investigated in juvenile rats. The rats were grouped into control, Hypo, Hypo-TQ5 and Hypo-TQ10. Propylthiouracil increased latency time in the Morris water maze test and decreased delay in entering the dark compartment in the passive avoidance test. Both 5 mg/kg and 10 mg/kg doses of TQ decreased latency time in the Morris water maze test and increased delay in entering the dark compartment in a passive avoidance test. The PTU also increased malondialdehyde and nitric oxide metabolites in the brain while reduced the thiol content and superoxide dismutase and catalase activities and serum T4 level. Both doses of TQ decreased malondialdehyde and nitric oxide metabolites in the brain while enhanced the thiol content and superoxide dismutase and catalase activities and serum T4 level. The results of the present study showed that TQ protected against PTU-induced memory impairments in rats.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000100032
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000100032
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282x20170182
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.76 n.1 2018
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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