Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infection
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000500004 |
Resumo: | Higher serum creatine kinase (CK) levels in critically ill patients with a confirmed 2009 influenza A (H1N1) infection suggests a possible relationship between the H1N1 virus and muscle tissue. However, there have been no reports with an emphasis on muscle biopsies for patients infected with the H1N1 virus. The objective of this study was to investigate the histological characteristics of the muscle biopsies from critically ill patients with confirmed 2009 H1N1 infections. A series of ten patients with confirmed 2009 H1N1 infection, who presented increased serum CK levels, was analyzed. Histological study found small histochemical alterations in muscles fibers (mainly in NADH, SDH, COX, myophosphorylase, adenylate deaminase and PAS stains), and no histological changes were compatible with inflammatory myopathy. Although our critically ill patients had elevated CK levels, they exhibited few histological/histochemical abnormalities in their muscle biopsy samples; however, those alterations could be consistent with metabolic dysfunction associated with influenza H1N1 infection. |
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Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infectionInfluenza A virusH1N1 subtypecreatine kinasemuscle biopsyHigher serum creatine kinase (CK) levels in critically ill patients with a confirmed 2009 influenza A (H1N1) infection suggests a possible relationship between the H1N1 virus and muscle tissue. However, there have been no reports with an emphasis on muscle biopsies for patients infected with the H1N1 virus. The objective of this study was to investigate the histological characteristics of the muscle biopsies from critically ill patients with confirmed 2009 H1N1 infections. A series of ten patients with confirmed 2009 H1N1 infection, who presented increased serum CK levels, was analyzed. Histological study found small histochemical alterations in muscles fibers (mainly in NADH, SDH, COX, myophosphorylase, adenylate deaminase and PAS stains), and no histological changes were compatible with inflammatory myopathy. Although our critically ill patients had elevated CK levels, they exhibited few histological/histochemical abnormalities in their muscle biopsy samples; however, those alterations could be consistent with metabolic dysfunction associated with influenza H1N1 infection.Academia Brasileira de Neurologia - ABNEURO2012-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000500004Arquivos de Neuro-Psiquiatria v.70 n.5 2012reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2012000500004info:eu-repo/semantics/openAccessLorenzoni,Paulo JoséKay,Cláudia Suemi KamoiScola,Rosana HerminiaCarraro Júnior,HipólitoWerneck,Lineu Cesareng2012-05-15T00:00:00Zoai:scielo:S0004-282X2012000500004Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2012-05-15T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infection |
title |
Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infection |
spellingShingle |
Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infection Lorenzoni,Paulo José Influenza A virus H1N1 subtype creatine kinase muscle biopsy |
title_short |
Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infection |
title_full |
Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infection |
title_fullStr |
Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infection |
title_full_unstemmed |
Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infection |
title_sort |
Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infection |
author |
Lorenzoni,Paulo José |
author_facet |
Lorenzoni,Paulo José Kay,Cláudia Suemi Kamoi Scola,Rosana Herminia Carraro Júnior,Hipólito Werneck,Lineu Cesar |
author_role |
author |
author2 |
Kay,Cláudia Suemi Kamoi Scola,Rosana Herminia Carraro Júnior,Hipólito Werneck,Lineu Cesar |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Lorenzoni,Paulo José Kay,Cláudia Suemi Kamoi Scola,Rosana Herminia Carraro Júnior,Hipólito Werneck,Lineu Cesar |
dc.subject.por.fl_str_mv |
Influenza A virus H1N1 subtype creatine kinase muscle biopsy |
topic |
Influenza A virus H1N1 subtype creatine kinase muscle biopsy |
description |
Higher serum creatine kinase (CK) levels in critically ill patients with a confirmed 2009 influenza A (H1N1) infection suggests a possible relationship between the H1N1 virus and muscle tissue. However, there have been no reports with an emphasis on muscle biopsies for patients infected with the H1N1 virus. The objective of this study was to investigate the histological characteristics of the muscle biopsies from critically ill patients with confirmed 2009 H1N1 infections. A series of ten patients with confirmed 2009 H1N1 infection, who presented increased serum CK levels, was analyzed. Histological study found small histochemical alterations in muscles fibers (mainly in NADH, SDH, COX, myophosphorylase, adenylate deaminase and PAS stains), and no histological changes were compatible with inflammatory myopathy. Although our critically ill patients had elevated CK levels, they exhibited few histological/histochemical abnormalities in their muscle biopsy samples; however, those alterations could be consistent with metabolic dysfunction associated with influenza H1N1 infection. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-05-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000500004 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000500004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2012000500004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.70 n.5 2012 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212773132238848 |