The role of vagus nerve stimulation in refractory epilepsy

Detalhes bibliográficos
Autor(a) principal: Oliveira,Tatiana Von Hertwig Fernandes de
Data de Publicação: 2017
Outros Autores: Francisco,Alexandre Novicki, Demartini Junior,Zeferino, Stebel,Sergio Leandro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000900657
Resumo: ABSTRACT Vagus nerve stimulation is an adjunctive therapy used to treat patients with refractory epilepsy who are not candidates for resective surgery or had poor results after surgical procedures. Its mechanism of action is not yet fully comprehended but it possibly involves modulation of the locus coeruleus, thalamus and limbic circuit through noradrenergic and serotonergic projections. There is sufficient evidence to support its use in patients with focal epilepsy and other seizure types. However, it should be recognized that improvement is not immediate and increases over time. The majority of adverse events is stimulation-related, temporary and decreases after adjustment of settings. Future perspectives to improve efficacy and reduce side effects, such as different approaches to increase battery life, transcutaneous stimulation and identification of prognostic factors, should be further investigated.
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spelling The role of vagus nerve stimulation in refractory epilepsyvagus nerve stimulationepilepsyABSTRACT Vagus nerve stimulation is an adjunctive therapy used to treat patients with refractory epilepsy who are not candidates for resective surgery or had poor results after surgical procedures. Its mechanism of action is not yet fully comprehended but it possibly involves modulation of the locus coeruleus, thalamus and limbic circuit through noradrenergic and serotonergic projections. There is sufficient evidence to support its use in patients with focal epilepsy and other seizure types. However, it should be recognized that improvement is not immediate and increases over time. The majority of adverse events is stimulation-related, temporary and decreases after adjustment of settings. Future perspectives to improve efficacy and reduce side effects, such as different approaches to increase battery life, transcutaneous stimulation and identification of prognostic factors, should be further investigated.Academia Brasileira de Neurologia - ABNEURO2017-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000900657Arquivos de Neuro-Psiquiatria v.75 n.9 2017reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20170113info:eu-repo/semantics/openAccessOliveira,Tatiana Von Hertwig Fernandes deFrancisco,Alexandre NovickiDemartini Junior,ZeferinoStebel,Sergio Leandroeng2017-09-20T00:00:00Zoai:scielo:S0004-282X2017000900657Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2017-09-20T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv The role of vagus nerve stimulation in refractory epilepsy
title The role of vagus nerve stimulation in refractory epilepsy
spellingShingle The role of vagus nerve stimulation in refractory epilepsy
Oliveira,Tatiana Von Hertwig Fernandes de
vagus nerve stimulation
epilepsy
title_short The role of vagus nerve stimulation in refractory epilepsy
title_full The role of vagus nerve stimulation in refractory epilepsy
title_fullStr The role of vagus nerve stimulation in refractory epilepsy
title_full_unstemmed The role of vagus nerve stimulation in refractory epilepsy
title_sort The role of vagus nerve stimulation in refractory epilepsy
author Oliveira,Tatiana Von Hertwig Fernandes de
author_facet Oliveira,Tatiana Von Hertwig Fernandes de
Francisco,Alexandre Novicki
Demartini Junior,Zeferino
Stebel,Sergio Leandro
author_role author
author2 Francisco,Alexandre Novicki
Demartini Junior,Zeferino
Stebel,Sergio Leandro
author2_role author
author
author
dc.contributor.author.fl_str_mv Oliveira,Tatiana Von Hertwig Fernandes de
Francisco,Alexandre Novicki
Demartini Junior,Zeferino
Stebel,Sergio Leandro
dc.subject.por.fl_str_mv vagus nerve stimulation
epilepsy
topic vagus nerve stimulation
epilepsy
description ABSTRACT Vagus nerve stimulation is an adjunctive therapy used to treat patients with refractory epilepsy who are not candidates for resective surgery or had poor results after surgical procedures. Its mechanism of action is not yet fully comprehended but it possibly involves modulation of the locus coeruleus, thalamus and limbic circuit through noradrenergic and serotonergic projections. There is sufficient evidence to support its use in patients with focal epilepsy and other seizure types. However, it should be recognized that improvement is not immediate and increases over time. The majority of adverse events is stimulation-related, temporary and decreases after adjustment of settings. Future perspectives to improve efficacy and reduce side effects, such as different approaches to increase battery life, transcutaneous stimulation and identification of prognostic factors, should be further investigated.
publishDate 2017
dc.date.none.fl_str_mv 2017-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000900657
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000900657
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282x20170113
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.75 n.9 2017
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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