Regional cerebral blood flow and cognitive function in patients with obsessive-compulsive disorder
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000100044 |
Resumo: | Objective: To explore the relationship between regional cerebral blood flow (CBF) and cognitive function in obsessive-compulsive disorder (OCD). Method: Single-photon emission computed tomography (SPECT) was performed for 139 OCD patients and 139 controls, and the radioactivity rate (RAR) was calculated. Cognitive function was assessed by the Wisconsin Card Sorting Test (WCST). Results: The RARs of the prefrontal, anterior temporal, and right occipital lobes were higher in patients than controls. For the WCST, correct and classification numbers were significantly lower, and errors and persistent errors were significantly higher in OCD patients. Right prefrontal lobe RAR was negatively correlated with correct numbers, right anterior temporal lobe RAR was positively correlated with errors, and the RARs of the right prefrontal lobe and left thalamus were positively correlated with persistent errors. Conclusion: OCD patients showed higher CBF in the prefrontal and anterior temporal lobes, suggesting that these areas may be related with cognitive impairment. |
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Arquivos de neuro-psiquiatria (Online) |
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Regional cerebral blood flow and cognitive function in patients with obsessive-compulsive disorderobsessive-compulsive disorderregional cerebral blood flowcognitive function Objective: To explore the relationship between regional cerebral blood flow (CBF) and cognitive function in obsessive-compulsive disorder (OCD). Method: Single-photon emission computed tomography (SPECT) was performed for 139 OCD patients and 139 controls, and the radioactivity rate (RAR) was calculated. Cognitive function was assessed by the Wisconsin Card Sorting Test (WCST). Results: The RARs of the prefrontal, anterior temporal, and right occipital lobes were higher in patients than controls. For the WCST, correct and classification numbers were significantly lower, and errors and persistent errors were significantly higher in OCD patients. Right prefrontal lobe RAR was negatively correlated with correct numbers, right anterior temporal lobe RAR was positively correlated with errors, and the RARs of the right prefrontal lobe and left thalamus were positively correlated with persistent errors. Conclusion: OCD patients showed higher CBF in the prefrontal and anterior temporal lobes, suggesting that these areas may be related with cognitive impairment. Academia Brasileira de Neurologia - ABNEURO2014-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000100044Arquivos de Neuro-Psiquiatria v.72 n.1 2014reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20130205info:eu-repo/semantics/openAccessGuo,HuirongZhao,NingLi,ZhengZhu,BinhuaCui,HeLi,Youhuieng2014-03-28T00:00:00Zoai:scielo:S0004-282X2014000100044Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2014-03-28T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Regional cerebral blood flow and cognitive function in patients with obsessive-compulsive disorder |
title |
Regional cerebral blood flow and cognitive function in patients with obsessive-compulsive disorder |
spellingShingle |
Regional cerebral blood flow and cognitive function in patients with obsessive-compulsive disorder Guo,Huirong obsessive-compulsive disorder regional cerebral blood flow cognitive function |
title_short |
Regional cerebral blood flow and cognitive function in patients with obsessive-compulsive disorder |
title_full |
Regional cerebral blood flow and cognitive function in patients with obsessive-compulsive disorder |
title_fullStr |
Regional cerebral blood flow and cognitive function in patients with obsessive-compulsive disorder |
title_full_unstemmed |
Regional cerebral blood flow and cognitive function in patients with obsessive-compulsive disorder |
title_sort |
Regional cerebral blood flow and cognitive function in patients with obsessive-compulsive disorder |
author |
Guo,Huirong |
author_facet |
Guo,Huirong Zhao,Ning Li,Zheng Zhu,Binhua Cui,He Li,Youhui |
author_role |
author |
author2 |
Zhao,Ning Li,Zheng Zhu,Binhua Cui,He Li,Youhui |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Guo,Huirong Zhao,Ning Li,Zheng Zhu,Binhua Cui,He Li,Youhui |
dc.subject.por.fl_str_mv |
obsessive-compulsive disorder regional cerebral blood flow cognitive function |
topic |
obsessive-compulsive disorder regional cerebral blood flow cognitive function |
description |
Objective: To explore the relationship between regional cerebral blood flow (CBF) and cognitive function in obsessive-compulsive disorder (OCD). Method: Single-photon emission computed tomography (SPECT) was performed for 139 OCD patients and 139 controls, and the radioactivity rate (RAR) was calculated. Cognitive function was assessed by the Wisconsin Card Sorting Test (WCST). Results: The RARs of the prefrontal, anterior temporal, and right occipital lobes were higher in patients than controls. For the WCST, correct and classification numbers were significantly lower, and errors and persistent errors were significantly higher in OCD patients. Right prefrontal lobe RAR was negatively correlated with correct numbers, right anterior temporal lobe RAR was positively correlated with errors, and the RARs of the right prefrontal lobe and left thalamus were positively correlated with persistent errors. Conclusion: OCD patients showed higher CBF in the prefrontal and anterior temporal lobes, suggesting that these areas may be related with cognitive impairment. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000100044 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000100044 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282X20130205 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.72 n.1 2014 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212775818690560 |