Caspase-3 and Bcl-2 expression in glioblastoma: an immunohistochemical study

Detalhes bibliográficos
Autor(a) principal: Tirapelli,Luís Fernando
Data de Publicação: 2010
Outros Autores: Bolini,Paulo Henrique Nasser Andre, Tirapelli,Daniela Pretti da Cunha, Peria,Fernanda Maris, Becker,Aline Nazareth Paixão, Saggioro,Fabiano Pinto, Carlotti Júnior,Carlos Gilberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000400023
Resumo: The unfavorable prognosis of malignant gliomas can also be explained by the incomplete knowledge of their molecular pathways. Studies regarding the regulatory process of apoptosis in glioblastoma (GBM), the most common malignant glioma, are few, and better knowledge of the expression of pro and anti-apoptotic proteins could collaborate with the development of new treatments founded on molecular basis. The objective of this study was to evaluate by immunohistochemistry the expression of caspase-3 and Bcl-2 in 30 samples of GBMs. The expression of caspase-3 (mean 17.67%) was lower than Bcl-2 (mean 30.92%), a statistically significant result (p<0.0001), suggesting low apoptotic activity in these tumors. Other studies of proteins related to the intrinsic and extrinsic pathway of apoptosis are required to provide additional information of this mechanism in GBMs.
id ABNEURO-1_845701158034e73948c9de577592bea8
oai_identifier_str oai:scielo:S0004-282X2010000400023
network_acronym_str ABNEURO-1
network_name_str Arquivos de neuro-psiquiatria (Online)
repository_id_str
spelling Caspase-3 and Bcl-2 expression in glioblastoma: an immunohistochemical studyglioblastomaapoptosisimmunohistochemistryThe unfavorable prognosis of malignant gliomas can also be explained by the incomplete knowledge of their molecular pathways. Studies regarding the regulatory process of apoptosis in glioblastoma (GBM), the most common malignant glioma, are few, and better knowledge of the expression of pro and anti-apoptotic proteins could collaborate with the development of new treatments founded on molecular basis. The objective of this study was to evaluate by immunohistochemistry the expression of caspase-3 and Bcl-2 in 30 samples of GBMs. The expression of caspase-3 (mean 17.67%) was lower than Bcl-2 (mean 30.92%), a statistically significant result (p<0.0001), suggesting low apoptotic activity in these tumors. Other studies of proteins related to the intrinsic and extrinsic pathway of apoptosis are required to provide additional information of this mechanism in GBMs.Academia Brasileira de Neurologia - ABNEURO2010-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000400023Arquivos de Neuro-Psiquiatria v.68 n.4 2010reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2010000400023info:eu-repo/semantics/openAccessTirapelli,Luís FernandoBolini,Paulo Henrique Nasser AndreTirapelli,Daniela Pretti da CunhaPeria,Fernanda MarisBecker,Aline Nazareth PaixãoSaggioro,Fabiano PintoCarlotti Júnior,Carlos Gilbertoeng2010-08-11T00:00:00Zoai:scielo:S0004-282X2010000400023Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2010-08-11T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Caspase-3 and Bcl-2 expression in glioblastoma: an immunohistochemical study
title Caspase-3 and Bcl-2 expression in glioblastoma: an immunohistochemical study
spellingShingle Caspase-3 and Bcl-2 expression in glioblastoma: an immunohistochemical study
Tirapelli,Luís Fernando
glioblastoma
apoptosis
immunohistochemistry
title_short Caspase-3 and Bcl-2 expression in glioblastoma: an immunohistochemical study
title_full Caspase-3 and Bcl-2 expression in glioblastoma: an immunohistochemical study
title_fullStr Caspase-3 and Bcl-2 expression in glioblastoma: an immunohistochemical study
title_full_unstemmed Caspase-3 and Bcl-2 expression in glioblastoma: an immunohistochemical study
title_sort Caspase-3 and Bcl-2 expression in glioblastoma: an immunohistochemical study
author Tirapelli,Luís Fernando
author_facet Tirapelli,Luís Fernando
Bolini,Paulo Henrique Nasser Andre
Tirapelli,Daniela Pretti da Cunha
Peria,Fernanda Maris
Becker,Aline Nazareth Paixão
Saggioro,Fabiano Pinto
Carlotti Júnior,Carlos Gilberto
author_role author
author2 Bolini,Paulo Henrique Nasser Andre
Tirapelli,Daniela Pretti da Cunha
Peria,Fernanda Maris
Becker,Aline Nazareth Paixão
Saggioro,Fabiano Pinto
Carlotti Júnior,Carlos Gilberto
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Tirapelli,Luís Fernando
Bolini,Paulo Henrique Nasser Andre
Tirapelli,Daniela Pretti da Cunha
Peria,Fernanda Maris
Becker,Aline Nazareth Paixão
Saggioro,Fabiano Pinto
Carlotti Júnior,Carlos Gilberto
dc.subject.por.fl_str_mv glioblastoma
apoptosis
immunohistochemistry
topic glioblastoma
apoptosis
immunohistochemistry
description The unfavorable prognosis of malignant gliomas can also be explained by the incomplete knowledge of their molecular pathways. Studies regarding the regulatory process of apoptosis in glioblastoma (GBM), the most common malignant glioma, are few, and better knowledge of the expression of pro and anti-apoptotic proteins could collaborate with the development of new treatments founded on molecular basis. The objective of this study was to evaluate by immunohistochemistry the expression of caspase-3 and Bcl-2 in 30 samples of GBMs. The expression of caspase-3 (mean 17.67%) was lower than Bcl-2 (mean 30.92%), a statistically significant result (p<0.0001), suggesting low apoptotic activity in these tumors. Other studies of proteins related to the intrinsic and extrinsic pathway of apoptosis are required to provide additional information of this mechanism in GBMs.
publishDate 2010
dc.date.none.fl_str_mv 2010-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000400023
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000400023
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2010000400023
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.68 n.4 2010
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
_version_ 1754212769094172672

Registros relacionados