Experimental nodel of C6 brain tumors in athymic rats
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000200019 |
Resumo: | Malignant brain tumor experimental models tend to employ cells that are immunologically compatible with the receptor animal. In this study, we have proposed an experimental model of encephalic tumor development by injecting C6 cells into athymic Rowett rats, aiming at reaching a model which more closely resembles to the human glioma tumor. In our model, we observed micro-infiltration of tumor cell clusters in the vicinity of the main tumor mass, and of more distal isolated tumor cells immersed in normal encephalic parenchyma. This degree of infiltration is superior to that usually observed in other C6 models. |
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Arquivos de neuro-psiquiatria (Online) |
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Experimental nodel of C6 brain tumors in athymic ratsbrain tumorC6 cellsexperimental modelgliomaMalignant brain tumor experimental models tend to employ cells that are immunologically compatible with the receptor animal. In this study, we have proposed an experimental model of encephalic tumor development by injecting C6 cells into athymic Rowett rats, aiming at reaching a model which more closely resembles to the human glioma tumor. In our model, we observed micro-infiltration of tumor cell clusters in the vicinity of the main tumor mass, and of more distal isolated tumor cells immersed in normal encephalic parenchyma. This degree of infiltration is superior to that usually observed in other C6 models.Academia Brasileira de Neurologia - ABNEURO2008-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000200019Arquivos de Neuro-Psiquiatria v.66 n.2a 2008reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2008000200019info:eu-repo/semantics/openAccessMiura,Flávio K.Alves,Maria José FerreiraRocha,Mussya CisottoSilva,Roseli S.Oba-Shinjo,Sueli M.Uno,M.Colin,C.Sogayar,M.C.Marie,Sueli K.N.eng2008-06-02T00:00:00Zoai:scielo:S0004-282X2008000200019Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2008-06-02T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Experimental nodel of C6 brain tumors in athymic rats |
title |
Experimental nodel of C6 brain tumors in athymic rats |
spellingShingle |
Experimental nodel of C6 brain tumors in athymic rats Miura,Flávio K. brain tumor C6 cells experimental model glioma |
title_short |
Experimental nodel of C6 brain tumors in athymic rats |
title_full |
Experimental nodel of C6 brain tumors in athymic rats |
title_fullStr |
Experimental nodel of C6 brain tumors in athymic rats |
title_full_unstemmed |
Experimental nodel of C6 brain tumors in athymic rats |
title_sort |
Experimental nodel of C6 brain tumors in athymic rats |
author |
Miura,Flávio K. |
author_facet |
Miura,Flávio K. Alves,Maria José Ferreira Rocha,Mussya Cisotto Silva,Roseli S. Oba-Shinjo,Sueli M. Uno,M. Colin,C. Sogayar,M.C. Marie,Sueli K.N. |
author_role |
author |
author2 |
Alves,Maria José Ferreira Rocha,Mussya Cisotto Silva,Roseli S. Oba-Shinjo,Sueli M. Uno,M. Colin,C. Sogayar,M.C. Marie,Sueli K.N. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Miura,Flávio K. Alves,Maria José Ferreira Rocha,Mussya Cisotto Silva,Roseli S. Oba-Shinjo,Sueli M. Uno,M. Colin,C. Sogayar,M.C. Marie,Sueli K.N. |
dc.subject.por.fl_str_mv |
brain tumor C6 cells experimental model glioma |
topic |
brain tumor C6 cells experimental model glioma |
description |
Malignant brain tumor experimental models tend to employ cells that are immunologically compatible with the receptor animal. In this study, we have proposed an experimental model of encephalic tumor development by injecting C6 cells into athymic Rowett rats, aiming at reaching a model which more closely resembles to the human glioma tumor. In our model, we observed micro-infiltration of tumor cell clusters in the vicinity of the main tumor mass, and of more distal isolated tumor cells immersed in normal encephalic parenchyma. This degree of infiltration is superior to that usually observed in other C6 models. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000200019 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000200019 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2008000200019 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.66 n.2a 2008 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212763802009600 |