Migraine in the triptan era: progresses achieved, lessons learned and future developments

Detalhes bibliográficos
Autor(a) principal: Bigal,Marcelo E.
Data de Publicação: 2009
Outros Autores: Krymchantowski,Abouch V., Ho,Tony
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000300040
Resumo: Triptans, serotonin 5-HT1B/1D receptor agonists, more than revolutionizing the treatment of migraine, stimulated also ground breaking research that provided insights into the anatomy, physiology, and molecular pharmacology of migraine. This knowledge, in turn, is stimulating research on new mechanisms of action for the treatment of migraine. Accordingly, it is opportune to critically review the main advances in migraine science that happened in the triptan era. Herein we first review and conceptualize some of the progresses achieved in migraine science during the triptan era. We then review the class of the triptans - mechanism of action and clinical evidence. We close by briefly discussing the class of CGRP receptor antagonists, which is currently being developed for the acute treatment of migraine.
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spelling Migraine in the triptan era: progresses achieved, lessons learned and future developmentsmigrainetriptansCGRP antagonistsemerging drugsTriptans, serotonin 5-HT1B/1D receptor agonists, more than revolutionizing the treatment of migraine, stimulated also ground breaking research that provided insights into the anatomy, physiology, and molecular pharmacology of migraine. This knowledge, in turn, is stimulating research on new mechanisms of action for the treatment of migraine. Accordingly, it is opportune to critically review the main advances in migraine science that happened in the triptan era. Herein we first review and conceptualize some of the progresses achieved in migraine science during the triptan era. We then review the class of the triptans - mechanism of action and clinical evidence. We close by briefly discussing the class of CGRP receptor antagonists, which is currently being developed for the acute treatment of migraine.Academia Brasileira de Neurologia - ABNEURO2009-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000300040Arquivos de Neuro-Psiquiatria v.67 n.2b 2009reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2009000300040info:eu-repo/semantics/openAccessBigal,Marcelo E.Krymchantowski,Abouch V.Ho,Tonyeng2009-07-13T00:00:00Zoai:scielo:S0004-282X2009000300040Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2009-07-13T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Migraine in the triptan era: progresses achieved, lessons learned and future developments
title Migraine in the triptan era: progresses achieved, lessons learned and future developments
spellingShingle Migraine in the triptan era: progresses achieved, lessons learned and future developments
Bigal,Marcelo E.
migraine
triptans
CGRP antagonists
emerging drugs
title_short Migraine in the triptan era: progresses achieved, lessons learned and future developments
title_full Migraine in the triptan era: progresses achieved, lessons learned and future developments
title_fullStr Migraine in the triptan era: progresses achieved, lessons learned and future developments
title_full_unstemmed Migraine in the triptan era: progresses achieved, lessons learned and future developments
title_sort Migraine in the triptan era: progresses achieved, lessons learned and future developments
author Bigal,Marcelo E.
author_facet Bigal,Marcelo E.
Krymchantowski,Abouch V.
Ho,Tony
author_role author
author2 Krymchantowski,Abouch V.
Ho,Tony
author2_role author
author
dc.contributor.author.fl_str_mv Bigal,Marcelo E.
Krymchantowski,Abouch V.
Ho,Tony
dc.subject.por.fl_str_mv migraine
triptans
CGRP antagonists
emerging drugs
topic migraine
triptans
CGRP antagonists
emerging drugs
description Triptans, serotonin 5-HT1B/1D receptor agonists, more than revolutionizing the treatment of migraine, stimulated also ground breaking research that provided insights into the anatomy, physiology, and molecular pharmacology of migraine. This knowledge, in turn, is stimulating research on new mechanisms of action for the treatment of migraine. Accordingly, it is opportune to critically review the main advances in migraine science that happened in the triptan era. Herein we first review and conceptualize some of the progresses achieved in migraine science during the triptan era. We then review the class of the triptans - mechanism of action and clinical evidence. We close by briefly discussing the class of CGRP receptor antagonists, which is currently being developed for the acute treatment of migraine.
publishDate 2009
dc.date.none.fl_str_mv 2009-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000300040
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000300040
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2009000300040
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.67 n.2b 2009
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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