Natalizumab treatment in multiple sclerosis: the experience from two Brazilian MS centers
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000900736 |
Resumo: | Objective Analyze the demographics, clinical characteristics, efficacy and safety of natalizumab treatment in Brazilian patients with multiple sclerosis (MS) followed up for at least 12 months, in two tertiary MS care centers in São Paulo.Method We evaluated the effect of natalizumab treatment on annualized relapse rate and disability progression in 75 patients with MS treated with natalizumab for at least 12 months. A subgroup analysis was performed to evaluate efficacy of natalizumab treatment in patients with Expanded Disability Status Scale (EDSS) ≤ 3.0 vs patients with EDSS > 3.Results Patients treated for at least one year with natalizumab showed a 91% reduction in aRR, as well and an improvement in neurological disability. The impact of natalizumab treatment was greater in patients with EDSS < 3.0. Overall, natalizumab was safe but one patient developed progressive multifocal leukoencephalopathy.Conclusion Natalizumab as a third line therapy is safe and efficacious, especially in patients with mild neurological disability. |
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Arquivos de neuro-psiquiatria (Online) |
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Natalizumab treatment in multiple sclerosis: the experience from two Brazilian MS centersnatalizumabmultiple sclerosisdisability progressionrelapse rateObjective Analyze the demographics, clinical characteristics, efficacy and safety of natalizumab treatment in Brazilian patients with multiple sclerosis (MS) followed up for at least 12 months, in two tertiary MS care centers in São Paulo.Method We evaluated the effect of natalizumab treatment on annualized relapse rate and disability progression in 75 patients with MS treated with natalizumab for at least 12 months. A subgroup analysis was performed to evaluate efficacy of natalizumab treatment in patients with Expanded Disability Status Scale (EDSS) ≤ 3.0 vs patients with EDSS > 3.Results Patients treated for at least one year with natalizumab showed a 91% reduction in aRR, as well and an improvement in neurological disability. The impact of natalizumab treatment was greater in patients with EDSS < 3.0. Overall, natalizumab was safe but one patient developed progressive multifocal leukoencephalopathy.Conclusion Natalizumab as a third line therapy is safe and efficacious, especially in patients with mild neurological disability.Academia Brasileira de Neurologia - ABNEURO2015-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000900736Arquivos de Neuro-Psiquiatria v.73 n.9 2015reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20150098info:eu-repo/semantics/openAccessOliveira,Enedina Maria Lobato deSimm,Renata FariaDasic,GoranaMorais,Marília Mamprim dePerreira,Samira Luiza dos ApostolosCallegaro,Dagobertoeng2015-08-31T00:00:00Zoai:scielo:S0004-282X2015000900736Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2015-08-31T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Natalizumab treatment in multiple sclerosis: the experience from two Brazilian MS centers |
title |
Natalizumab treatment in multiple sclerosis: the experience from two Brazilian MS centers |
spellingShingle |
Natalizumab treatment in multiple sclerosis: the experience from two Brazilian MS centers Oliveira,Enedina Maria Lobato de natalizumab multiple sclerosis disability progression relapse rate |
title_short |
Natalizumab treatment in multiple sclerosis: the experience from two Brazilian MS centers |
title_full |
Natalizumab treatment in multiple sclerosis: the experience from two Brazilian MS centers |
title_fullStr |
Natalizumab treatment in multiple sclerosis: the experience from two Brazilian MS centers |
title_full_unstemmed |
Natalizumab treatment in multiple sclerosis: the experience from two Brazilian MS centers |
title_sort |
Natalizumab treatment in multiple sclerosis: the experience from two Brazilian MS centers |
author |
Oliveira,Enedina Maria Lobato de |
author_facet |
Oliveira,Enedina Maria Lobato de Simm,Renata Faria Dasic,Gorana Morais,Marília Mamprim de Perreira,Samira Luiza dos Apostolos Callegaro,Dagoberto |
author_role |
author |
author2 |
Simm,Renata Faria Dasic,Gorana Morais,Marília Mamprim de Perreira,Samira Luiza dos Apostolos Callegaro,Dagoberto |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira,Enedina Maria Lobato de Simm,Renata Faria Dasic,Gorana Morais,Marília Mamprim de Perreira,Samira Luiza dos Apostolos Callegaro,Dagoberto |
dc.subject.por.fl_str_mv |
natalizumab multiple sclerosis disability progression relapse rate |
topic |
natalizumab multiple sclerosis disability progression relapse rate |
description |
Objective Analyze the demographics, clinical characteristics, efficacy and safety of natalizumab treatment in Brazilian patients with multiple sclerosis (MS) followed up for at least 12 months, in two tertiary MS care centers in São Paulo.Method We evaluated the effect of natalizumab treatment on annualized relapse rate and disability progression in 75 patients with MS treated with natalizumab for at least 12 months. A subgroup analysis was performed to evaluate efficacy of natalizumab treatment in patients with Expanded Disability Status Scale (EDSS) ≤ 3.0 vs patients with EDSS > 3.Results Patients treated for at least one year with natalizumab showed a 91% reduction in aRR, as well and an improvement in neurological disability. The impact of natalizumab treatment was greater in patients with EDSS < 3.0. Overall, natalizumab was safe but one patient developed progressive multifocal leukoencephalopathy.Conclusion Natalizumab as a third line therapy is safe and efficacious, especially in patients with mild neurological disability. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000900736 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000900736 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282X20150098 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.73 n.9 2015 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212778558619648 |