Natalizumab treatment in multiple sclerosis: the experience from two Brazilian MS centers

Detalhes bibliográficos
Autor(a) principal: Oliveira,Enedina Maria Lobato de
Data de Publicação: 2015
Outros Autores: Simm,Renata Faria, Dasic,Gorana, Morais,Marília Mamprim de, Perreira,Samira Luiza dos Apostolos, Callegaro,Dagoberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000900736
Resumo: Objective Analyze the demographics, clinical characteristics, efficacy and safety of natalizumab treatment in Brazilian patients with multiple sclerosis (MS) followed up for at least 12 months, in two tertiary MS care centers in São Paulo.Method We evaluated the effect of natalizumab treatment on annualized relapse rate and disability progression in 75 patients with MS treated with natalizumab for at least 12 months. A subgroup analysis was performed to evaluate efficacy of natalizumab treatment in patients with Expanded Disability Status Scale (EDSS) ≤ 3.0 vs patients with EDSS > 3.Results Patients treated for at least one year with natalizumab showed a 91% reduction in aRR, as well and an improvement in neurological disability. The impact of natalizumab treatment was greater in patients with EDSS < 3.0. Overall, natalizumab was safe but one patient developed progressive multifocal leukoencephalopathy.Conclusion Natalizumab as a third line therapy is safe and efficacious, especially in patients with mild neurological disability.
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spelling Natalizumab treatment in multiple sclerosis: the experience from two Brazilian MS centersnatalizumabmultiple sclerosisdisability progressionrelapse rateObjective Analyze the demographics, clinical characteristics, efficacy and safety of natalizumab treatment in Brazilian patients with multiple sclerosis (MS) followed up for at least 12 months, in two tertiary MS care centers in São Paulo.Method We evaluated the effect of natalizumab treatment on annualized relapse rate and disability progression in 75 patients with MS treated with natalizumab for at least 12 months. A subgroup analysis was performed to evaluate efficacy of natalizumab treatment in patients with Expanded Disability Status Scale (EDSS) ≤ 3.0 vs patients with EDSS > 3.Results Patients treated for at least one year with natalizumab showed a 91% reduction in aRR, as well and an improvement in neurological disability. The impact of natalizumab treatment was greater in patients with EDSS < 3.0. Overall, natalizumab was safe but one patient developed progressive multifocal leukoencephalopathy.Conclusion Natalizumab as a third line therapy is safe and efficacious, especially in patients with mild neurological disability.Academia Brasileira de Neurologia - ABNEURO2015-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000900736Arquivos de Neuro-Psiquiatria v.73 n.9 2015reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20150098info:eu-repo/semantics/openAccessOliveira,Enedina Maria Lobato deSimm,Renata FariaDasic,GoranaMorais,Marília Mamprim dePerreira,Samira Luiza dos ApostolosCallegaro,Dagobertoeng2015-08-31T00:00:00Zoai:scielo:S0004-282X2015000900736Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2015-08-31T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Natalizumab treatment in multiple sclerosis: the experience from two Brazilian MS centers
title Natalizumab treatment in multiple sclerosis: the experience from two Brazilian MS centers
spellingShingle Natalizumab treatment in multiple sclerosis: the experience from two Brazilian MS centers
Oliveira,Enedina Maria Lobato de
natalizumab
multiple sclerosis
disability progression
relapse rate
title_short Natalizumab treatment in multiple sclerosis: the experience from two Brazilian MS centers
title_full Natalizumab treatment in multiple sclerosis: the experience from two Brazilian MS centers
title_fullStr Natalizumab treatment in multiple sclerosis: the experience from two Brazilian MS centers
title_full_unstemmed Natalizumab treatment in multiple sclerosis: the experience from two Brazilian MS centers
title_sort Natalizumab treatment in multiple sclerosis: the experience from two Brazilian MS centers
author Oliveira,Enedina Maria Lobato de
author_facet Oliveira,Enedina Maria Lobato de
Simm,Renata Faria
Dasic,Gorana
Morais,Marília Mamprim de
Perreira,Samira Luiza dos Apostolos
Callegaro,Dagoberto
author_role author
author2 Simm,Renata Faria
Dasic,Gorana
Morais,Marília Mamprim de
Perreira,Samira Luiza dos Apostolos
Callegaro,Dagoberto
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira,Enedina Maria Lobato de
Simm,Renata Faria
Dasic,Gorana
Morais,Marília Mamprim de
Perreira,Samira Luiza dos Apostolos
Callegaro,Dagoberto
dc.subject.por.fl_str_mv natalizumab
multiple sclerosis
disability progression
relapse rate
topic natalizumab
multiple sclerosis
disability progression
relapse rate
description Objective Analyze the demographics, clinical characteristics, efficacy and safety of natalizumab treatment in Brazilian patients with multiple sclerosis (MS) followed up for at least 12 months, in two tertiary MS care centers in São Paulo.Method We evaluated the effect of natalizumab treatment on annualized relapse rate and disability progression in 75 patients with MS treated with natalizumab for at least 12 months. A subgroup analysis was performed to evaluate efficacy of natalizumab treatment in patients with Expanded Disability Status Scale (EDSS) ≤ 3.0 vs patients with EDSS > 3.Results Patients treated for at least one year with natalizumab showed a 91% reduction in aRR, as well and an improvement in neurological disability. The impact of natalizumab treatment was greater in patients with EDSS < 3.0. Overall, natalizumab was safe but one patient developed progressive multifocal leukoencephalopathy.Conclusion Natalizumab as a third line therapy is safe and efficacious, especially in patients with mild neurological disability.
publishDate 2015
dc.date.none.fl_str_mv 2015-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000900736
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000900736
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282X20150098
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.73 n.9 2015
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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