Basal cortisol levels and the relationship with clinical symptoms in multiple sclerosis: a systematic review

• Autor(a) principal: Pereira,Gabriela Magalhães
• Data de Publicação: 2018
• Outros Autores: Soares,Nayron Medeiros, Souza,Andreo Rysdyk de, Becker,Jefferson, Finkelsztejn,Alessandro, Almeida,Rosa Maria Martins de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos de neuro-psiquiatria (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000900622
• topic: Multiple sclerosis; hydrocortisone; pituitary-adrenal system; neurologic manifestations; general symptoms

ABSTRACT Multiple sclerosis (MS) is a demyelinating, progressive and neurodegenerative disease. A disturbance on the hypothalamic-pituitary-adrenal axis can be observed in patients with MS, showing altered cortisol levels. We aimed to identify basal cortisol levels and verify the relationship with clinical symptoms in patients with MS. A systematic search was conducted in the databases: Pubmed, Web of Science and SCOPUS. Both higher and lower cortisol levels were associated with MS. Higher cortisol levels were associated with depression and anxiety, while lower levels were associated with depression, fatigue and urinary dysfunction. Higher cortisol levels may be associated with the progression and severity of MS.