Leprosy late-onset neuropathy: an uncommon presentation of leprosy
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000600004 |
Resumo: | Clinical and pathological findings in leprosy are determined by the natural host immune response to Mycobacterium leprae. We previously described cases of painful neuropathy (PN) with no concurrent cause apart from a past history of leprosy successfully treated. Four leprosy previously treated patients who developed a PN years after multidrug therapy (MDT) are reported. The mean patient age was 52.75 years (47-64). The mean time interval of the recent neuropathy from the previous MDT was 19 years (12-26). A painful multiplex neuritis or polyneuropathy were observed respectively in two cases. Electrophysiological studies disclosed a sensory axonal neuropathy in two cases. Microvasculitis with no bacilli was seen in nerve biopsy. Neuropathic symptoms were improved with prednisone. We consider these cases as being a leprosy late-onset neuropathy (LLON) form of presentation. A delayed immune reaction could explain the late appearance of LLON. |
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Leprosy late-onset neuropathy: an uncommon presentation of leprosyleprosylate-onset neuropathynerve conductionnerve biopsytherapyClinical and pathological findings in leprosy are determined by the natural host immune response to Mycobacterium leprae. We previously described cases of painful neuropathy (PN) with no concurrent cause apart from a past history of leprosy successfully treated. Four leprosy previously treated patients who developed a PN years after multidrug therapy (MDT) are reported. The mean patient age was 52.75 years (47-64). The mean time interval of the recent neuropathy from the previous MDT was 19 years (12-26). A painful multiplex neuritis or polyneuropathy were observed respectively in two cases. Electrophysiological studies disclosed a sensory axonal neuropathy in two cases. Microvasculitis with no bacilli was seen in nerve biopsy. Neuropathic symptoms were improved with prednisone. We consider these cases as being a leprosy late-onset neuropathy (LLON) form of presentation. A delayed immune reaction could explain the late appearance of LLON.Academia Brasileira de Neurologia - ABNEURO2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000600004Arquivos de Neuro-Psiquiatria v.70 n.6 2012reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2012000600004info:eu-repo/semantics/openAccessNascimento,Osvaldo J.M.Freitas,Marcos R. G. deEscada,TaniaMarques Junior,WilsonCardoso,FernandoPupe,CamilaDuraes,Sandraeng2012-06-11T00:00:00Zoai:scielo:S0004-282X2012000600004Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2012-06-11T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Leprosy late-onset neuropathy: an uncommon presentation of leprosy |
title |
Leprosy late-onset neuropathy: an uncommon presentation of leprosy |
spellingShingle |
Leprosy late-onset neuropathy: an uncommon presentation of leprosy Nascimento,Osvaldo J.M. leprosy late-onset neuropathy nerve conduction nerve biopsy therapy |
title_short |
Leprosy late-onset neuropathy: an uncommon presentation of leprosy |
title_full |
Leprosy late-onset neuropathy: an uncommon presentation of leprosy |
title_fullStr |
Leprosy late-onset neuropathy: an uncommon presentation of leprosy |
title_full_unstemmed |
Leprosy late-onset neuropathy: an uncommon presentation of leprosy |
title_sort |
Leprosy late-onset neuropathy: an uncommon presentation of leprosy |
author |
Nascimento,Osvaldo J.M. |
author_facet |
Nascimento,Osvaldo J.M. Freitas,Marcos R. G. de Escada,Tania Marques Junior,Wilson Cardoso,Fernando Pupe,Camila Duraes,Sandra |
author_role |
author |
author2 |
Freitas,Marcos R. G. de Escada,Tania Marques Junior,Wilson Cardoso,Fernando Pupe,Camila Duraes,Sandra |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Nascimento,Osvaldo J.M. Freitas,Marcos R. G. de Escada,Tania Marques Junior,Wilson Cardoso,Fernando Pupe,Camila Duraes,Sandra |
dc.subject.por.fl_str_mv |
leprosy late-onset neuropathy nerve conduction nerve biopsy therapy |
topic |
leprosy late-onset neuropathy nerve conduction nerve biopsy therapy |
description |
Clinical and pathological findings in leprosy are determined by the natural host immune response to Mycobacterium leprae. We previously described cases of painful neuropathy (PN) with no concurrent cause apart from a past history of leprosy successfully treated. Four leprosy previously treated patients who developed a PN years after multidrug therapy (MDT) are reported. The mean patient age was 52.75 years (47-64). The mean time interval of the recent neuropathy from the previous MDT was 19 years (12-26). A painful multiplex neuritis or polyneuropathy were observed respectively in two cases. Electrophysiological studies disclosed a sensory axonal neuropathy in two cases. Microvasculitis with no bacilli was seen in nerve biopsy. Neuropathic symptoms were improved with prednisone. We consider these cases as being a leprosy late-onset neuropathy (LLON) form of presentation. A delayed immune reaction could explain the late appearance of LLON. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000600004 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000600004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2012000600004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.70 n.6 2012 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
_version_ |
1754212773294768128 |