Leprosy late-onset neuropathy: an uncommon presentation of leprosy

Detalhes bibliográficos
Autor(a) principal: Nascimento,Osvaldo J.M.
Data de Publicação: 2012
Outros Autores: Freitas,Marcos R. G. de, Escada,Tania, Marques Junior,Wilson, Cardoso,Fernando, Pupe,Camila, Duraes,Sandra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000600004
Resumo: Clinical and pathological findings in leprosy are determined by the natural host immune response to Mycobacterium leprae. We previously described cases of painful neuropathy (PN) with no concurrent cause apart from a past history of leprosy successfully treated. Four leprosy previously treated patients who developed a PN years after multidrug therapy (MDT) are reported. The mean patient age was 52.75 years (47-64). The mean time interval of the recent neuropathy from the previous MDT was 19 years (12-26). A painful multiplex neuritis or polyneuropathy were observed respectively in two cases. Electrophysiological studies disclosed a sensory axonal neuropathy in two cases. Microvasculitis with no bacilli was seen in nerve biopsy. Neuropathic symptoms were improved with prednisone. We consider these cases as being a leprosy late-onset neuropathy (LLON) form of presentation. A delayed immune reaction could explain the late appearance of LLON.
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spelling Leprosy late-onset neuropathy: an uncommon presentation of leprosyleprosylate-onset neuropathynerve conductionnerve biopsytherapyClinical and pathological findings in leprosy are determined by the natural host immune response to Mycobacterium leprae. We previously described cases of painful neuropathy (PN) with no concurrent cause apart from a past history of leprosy successfully treated. Four leprosy previously treated patients who developed a PN years after multidrug therapy (MDT) are reported. The mean patient age was 52.75 years (47-64). The mean time interval of the recent neuropathy from the previous MDT was 19 years (12-26). A painful multiplex neuritis or polyneuropathy were observed respectively in two cases. Electrophysiological studies disclosed a sensory axonal neuropathy in two cases. Microvasculitis with no bacilli was seen in nerve biopsy. Neuropathic symptoms were improved with prednisone. We consider these cases as being a leprosy late-onset neuropathy (LLON) form of presentation. A delayed immune reaction could explain the late appearance of LLON.Academia Brasileira de Neurologia - ABNEURO2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000600004Arquivos de Neuro-Psiquiatria v.70 n.6 2012reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2012000600004info:eu-repo/semantics/openAccessNascimento,Osvaldo J.M.Freitas,Marcos R. G. deEscada,TaniaMarques Junior,WilsonCardoso,FernandoPupe,CamilaDuraes,Sandraeng2012-06-11T00:00:00Zoai:scielo:S0004-282X2012000600004Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2012-06-11T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Leprosy late-onset neuropathy: an uncommon presentation of leprosy
title Leprosy late-onset neuropathy: an uncommon presentation of leprosy
spellingShingle Leprosy late-onset neuropathy: an uncommon presentation of leprosy
Nascimento,Osvaldo J.M.
leprosy
late-onset neuropathy
nerve conduction
nerve biopsy
therapy
title_short Leprosy late-onset neuropathy: an uncommon presentation of leprosy
title_full Leprosy late-onset neuropathy: an uncommon presentation of leprosy
title_fullStr Leprosy late-onset neuropathy: an uncommon presentation of leprosy
title_full_unstemmed Leprosy late-onset neuropathy: an uncommon presentation of leprosy
title_sort Leprosy late-onset neuropathy: an uncommon presentation of leprosy
author Nascimento,Osvaldo J.M.
author_facet Nascimento,Osvaldo J.M.
Freitas,Marcos R. G. de
Escada,Tania
Marques Junior,Wilson
Cardoso,Fernando
Pupe,Camila
Duraes,Sandra
author_role author
author2 Freitas,Marcos R. G. de
Escada,Tania
Marques Junior,Wilson
Cardoso,Fernando
Pupe,Camila
Duraes,Sandra
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nascimento,Osvaldo J.M.
Freitas,Marcos R. G. de
Escada,Tania
Marques Junior,Wilson
Cardoso,Fernando
Pupe,Camila
Duraes,Sandra
dc.subject.por.fl_str_mv leprosy
late-onset neuropathy
nerve conduction
nerve biopsy
therapy
topic leprosy
late-onset neuropathy
nerve conduction
nerve biopsy
therapy
description Clinical and pathological findings in leprosy are determined by the natural host immune response to Mycobacterium leprae. We previously described cases of painful neuropathy (PN) with no concurrent cause apart from a past history of leprosy successfully treated. Four leprosy previously treated patients who developed a PN years after multidrug therapy (MDT) are reported. The mean patient age was 52.75 years (47-64). The mean time interval of the recent neuropathy from the previous MDT was 19 years (12-26). A painful multiplex neuritis or polyneuropathy were observed respectively in two cases. Electrophysiological studies disclosed a sensory axonal neuropathy in two cases. Microvasculitis with no bacilli was seen in nerve biopsy. Neuropathic symptoms were improved with prednisone. We consider these cases as being a leprosy late-onset neuropathy (LLON) form of presentation. A delayed immune reaction could explain the late appearance of LLON.
publishDate 2012
dc.date.none.fl_str_mv 2012-06-01
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000600004
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2012000600004
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.70 n.6 2012
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
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reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
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