Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunction

Detalhes bibliográficos
Autor(a) principal: Torres,Karen Cecília de Lima
Data de Publicação: 2016
Outros Autores: Rocha,Natália Pessoa, Rezende,Vítor Bortolo de, Dutra,Walderez Ornelas, Gollob,Kenneth John, Cardoso,Francisco, Teixeira,Antonio Lucio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000100005
Resumo: The mechanisms involved in the symptoms of Sydenham’s chorea (SC) remain obscure. Taking into account the autoreactive antibody-mediated hypothesis of SC pathogenesis, the persistence of chorea may be associated with increased levels of B1 lymphocytes and other lymphocyte subsets. We evaluated lymphocyte subsets, including B1 and T cells, in patients with remitted (RSC) and persistent (PSC) SC by flow cytometry. Our results showed neither difference in the frequency of T and B lymphocytes subpopulations nor in their activation and functional states. These findings undermine the view of PSC as a sustained cytotoxic cellular-mediated condition. Alternative mechanisms may explain the pathogenesis of PSC.
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spelling Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunctionSydenham choreaautoimmunitylymphocytesB1 cellsThe mechanisms involved in the symptoms of Sydenham’s chorea (SC) remain obscure. Taking into account the autoreactive antibody-mediated hypothesis of SC pathogenesis, the persistence of chorea may be associated with increased levels of B1 lymphocytes and other lymphocyte subsets. We evaluated lymphocyte subsets, including B1 and T cells, in patients with remitted (RSC) and persistent (PSC) SC by flow cytometry. Our results showed neither difference in the frequency of T and B lymphocytes subpopulations nor in their activation and functional states. These findings undermine the view of PSC as a sustained cytotoxic cellular-mediated condition. Alternative mechanisms may explain the pathogenesis of PSC.Academia Brasileira de Neurologia - ABNEURO2016-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000100005Arquivos de Neuro-Psiquiatria v.74 n.1 2016reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20150179info:eu-repo/semantics/openAccessTorres,Karen Cecília de LimaRocha,Natália PessoaRezende,Vítor Bortolo deDutra,Walderez OrnelasGollob,Kenneth JohnCardoso,FranciscoTeixeira,Antonio Lucioeng2016-02-05T00:00:00Zoai:scielo:S0004-282X2016000100005Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2016-02-05T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunction
title Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunction
spellingShingle Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunction
Torres,Karen Cecília de Lima
Sydenham chorea
autoimmunity
lymphocytes
B1 cells
title_short Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunction
title_full Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunction
title_fullStr Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunction
title_full_unstemmed Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunction
title_sort Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunction
author Torres,Karen Cecília de Lima
author_facet Torres,Karen Cecília de Lima
Rocha,Natália Pessoa
Rezende,Vítor Bortolo de
Dutra,Walderez Ornelas
Gollob,Kenneth John
Cardoso,Francisco
Teixeira,Antonio Lucio
author_role author
author2 Rocha,Natália Pessoa
Rezende,Vítor Bortolo de
Dutra,Walderez Ornelas
Gollob,Kenneth John
Cardoso,Francisco
Teixeira,Antonio Lucio
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Torres,Karen Cecília de Lima
Rocha,Natália Pessoa
Rezende,Vítor Bortolo de
Dutra,Walderez Ornelas
Gollob,Kenneth John
Cardoso,Francisco
Teixeira,Antonio Lucio
dc.subject.por.fl_str_mv Sydenham chorea
autoimmunity
lymphocytes
B1 cells
topic Sydenham chorea
autoimmunity
lymphocytes
B1 cells
description The mechanisms involved in the symptoms of Sydenham’s chorea (SC) remain obscure. Taking into account the autoreactive antibody-mediated hypothesis of SC pathogenesis, the persistence of chorea may be associated with increased levels of B1 lymphocytes and other lymphocyte subsets. We evaluated lymphocyte subsets, including B1 and T cells, in patients with remitted (RSC) and persistent (PSC) SC by flow cytometry. Our results showed neither difference in the frequency of T and B lymphocytes subpopulations nor in their activation and functional states. These findings undermine the view of PSC as a sustained cytotoxic cellular-mediated condition. Alternative mechanisms may explain the pathogenesis of PSC.
publishDate 2016
dc.date.none.fl_str_mv 2016-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000100005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000100005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282X20150179
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.74 n.1 2016
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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