Neuroprotective effect of mild hypothermia in the temporary brain ischemia in cats

Detalhes bibliográficos
Autor(a) principal: Nakano,Hiroshi
Data de Publicação: 2007
Outros Autores: Colli,Benedicto Oscar, Lopes,Luiza da Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000500015
Resumo: OBJECTIVE: To evaluate the neuroprotective effect of mild hypothermia during temporary focal ischemia in cats. METHOD: 20 cats underwent middle cerebral artery 60 minutes occlusion and 24 hours reperfusion: 10 under normothermia and 10 under mild hypothermia (32º C). Brain coronal sections 2mm thick were stained with 2,3,5-triphenyltetrazolium hydrochloride, photographed and evaluated with software for volume calculation. RESULTS:Cortical ischemia was found in 7 and basal ganglia ischemia in 8 animals of group 1 and in both regions in 5 animals of group 2 (no difference: p=0.6499 for cortical; p=0.3498 for basal ganglia). No ischemia was found in 5 animals of group 2 and in none of group 1 (significant difference, p=0.0325). The infarct volume was greater in group 1 than 2 (p=0.0433). CONCLUSION: Mild hypothermia did not interfere with location of ischemia, but it was effective for reducing the infarct volume.
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spelling Neuroprotective effect of mild hypothermia in the temporary brain ischemia in catscatsfocal cerebral ischemiamild hypothermianeuroprotectionOBJECTIVE: To evaluate the neuroprotective effect of mild hypothermia during temporary focal ischemia in cats. METHOD: 20 cats underwent middle cerebral artery 60 minutes occlusion and 24 hours reperfusion: 10 under normothermia and 10 under mild hypothermia (32º C). Brain coronal sections 2mm thick were stained with 2,3,5-triphenyltetrazolium hydrochloride, photographed and evaluated with software for volume calculation. RESULTS:Cortical ischemia was found in 7 and basal ganglia ischemia in 8 animals of group 1 and in both regions in 5 animals of group 2 (no difference: p=0.6499 for cortical; p=0.3498 for basal ganglia). No ischemia was found in 5 animals of group 2 and in none of group 1 (significant difference, p=0.0325). The infarct volume was greater in group 1 than 2 (p=0.0433). CONCLUSION: Mild hypothermia did not interfere with location of ischemia, but it was effective for reducing the infarct volume.Academia Brasileira de Neurologia - ABNEURO2007-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000500015Arquivos de Neuro-Psiquiatria v.65 n.3b 2007reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2007000500015info:eu-repo/semantics/openAccessNakano,HiroshiColli,Benedicto OscarLopes,Luiza da Silvaeng2008-04-11T00:00:00Zoai:scielo:S0004-282X2007000500015Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2008-04-11T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Neuroprotective effect of mild hypothermia in the temporary brain ischemia in cats
title Neuroprotective effect of mild hypothermia in the temporary brain ischemia in cats
spellingShingle Neuroprotective effect of mild hypothermia in the temporary brain ischemia in cats
Nakano,Hiroshi
cats
focal cerebral ischemia
mild hypothermia
neuroprotection
title_short Neuroprotective effect of mild hypothermia in the temporary brain ischemia in cats
title_full Neuroprotective effect of mild hypothermia in the temporary brain ischemia in cats
title_fullStr Neuroprotective effect of mild hypothermia in the temporary brain ischemia in cats
title_full_unstemmed Neuroprotective effect of mild hypothermia in the temporary brain ischemia in cats
title_sort Neuroprotective effect of mild hypothermia in the temporary brain ischemia in cats
author Nakano,Hiroshi
author_facet Nakano,Hiroshi
Colli,Benedicto Oscar
Lopes,Luiza da Silva
author_role author
author2 Colli,Benedicto Oscar
Lopes,Luiza da Silva
author2_role author
author
dc.contributor.author.fl_str_mv Nakano,Hiroshi
Colli,Benedicto Oscar
Lopes,Luiza da Silva
dc.subject.por.fl_str_mv cats
focal cerebral ischemia
mild hypothermia
neuroprotection
topic cats
focal cerebral ischemia
mild hypothermia
neuroprotection
description OBJECTIVE: To evaluate the neuroprotective effect of mild hypothermia during temporary focal ischemia in cats. METHOD: 20 cats underwent middle cerebral artery 60 minutes occlusion and 24 hours reperfusion: 10 under normothermia and 10 under mild hypothermia (32º C). Brain coronal sections 2mm thick were stained with 2,3,5-triphenyltetrazolium hydrochloride, photographed and evaluated with software for volume calculation. RESULTS:Cortical ischemia was found in 7 and basal ganglia ischemia in 8 animals of group 1 and in both regions in 5 animals of group 2 (no difference: p=0.6499 for cortical; p=0.3498 for basal ganglia). No ischemia was found in 5 animals of group 2 and in none of group 1 (significant difference, p=0.0325). The infarct volume was greater in group 1 than 2 (p=0.0433). CONCLUSION: Mild hypothermia did not interfere with location of ischemia, but it was effective for reducing the infarct volume.
publishDate 2007
dc.date.none.fl_str_mv 2007-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000500015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000500015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2007000500015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.65 n.3b 2007
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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