Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000700601 |
Resumo: | Objective This study evaluated the provision of two configuration of the Elevated Pluz-Maze (EPM) by analizing the exploratory behaviour of female Wistar rats in different phases of the estrous cycle in EPMs with different gradients of luminosity between the open and enclosed arms (O/E∆Lux).Methods Female Wistar rats were treated with Midazolam (MDZ, 1.0 mg.kg-1) and were tested for their exploratory behaviour in either the EPM 10 O/E∆Lux or EPM 96 O/E∆Lux.Results A multiple regression analysis indicated that the O/E∆Lux is negatively associated with the %Open arm entries and %Open arm time, suggesting that as O/E∆Lux increases, the open arm exploration decreases. The estrous cycle phase did not influence the open-arm exploration in either EPM. MDZ- induced anxiolysis was detected in 96 O/E∆Lux EPM in all phases of the EC.Discussion Results of this study suggest the importance of the O/E∆Lux to establish the arm preference in the EPM, and to preserve the predictive validity of the EPM. |
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Arquivos de neuro-psiquiatria (Online) |
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Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar ratsestrous cyclefemaleWistar ratsanxietyfearelevated plus-mazeluminosityObjective This study evaluated the provision of two configuration of the Elevated Pluz-Maze (EPM) by analizing the exploratory behaviour of female Wistar rats in different phases of the estrous cycle in EPMs with different gradients of luminosity between the open and enclosed arms (O/E∆Lux).Methods Female Wistar rats were treated with Midazolam (MDZ, 1.0 mg.kg-1) and were tested for their exploratory behaviour in either the EPM 10 O/E∆Lux or EPM 96 O/E∆Lux.Results A multiple regression analysis indicated that the O/E∆Lux is negatively associated with the %Open arm entries and %Open arm time, suggesting that as O/E∆Lux increases, the open arm exploration decreases. The estrous cycle phase did not influence the open-arm exploration in either EPM. MDZ- induced anxiolysis was detected in 96 O/E∆Lux EPM in all phases of the EC.Discussion Results of this study suggest the importance of the O/E∆Lux to establish the arm preference in the EPM, and to preserve the predictive validity of the EPM.Academia Brasileira de Neurologia - ABNEURO2015-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000700601Arquivos de Neuro-Psiquiatria v.73 n.7 2015reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20150088info:eu-repo/semantics/openAccessSakae,Diana YaeSakae,Thiago MamoruPaschoalini,Marta AparecidaFaria,Moacir Serralvoeng2015-07-16T00:00:00Zoai:scielo:S0004-282X2015000700601Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2015-07-16T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats |
title |
Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats |
spellingShingle |
Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats Sakae,Diana Yae estrous cycle female Wistar rats anxiety fear elevated plus-maze luminosity |
title_short |
Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats |
title_full |
Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats |
title_fullStr |
Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats |
title_full_unstemmed |
Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats |
title_sort |
Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats |
author |
Sakae,Diana Yae |
author_facet |
Sakae,Diana Yae Sakae,Thiago Mamoru Paschoalini,Marta Aparecida Faria,Moacir Serralvo |
author_role |
author |
author2 |
Sakae,Thiago Mamoru Paschoalini,Marta Aparecida Faria,Moacir Serralvo |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Sakae,Diana Yae Sakae,Thiago Mamoru Paschoalini,Marta Aparecida Faria,Moacir Serralvo |
dc.subject.por.fl_str_mv |
estrous cycle female Wistar rats anxiety fear elevated plus-maze luminosity |
topic |
estrous cycle female Wistar rats anxiety fear elevated plus-maze luminosity |
description |
Objective This study evaluated the provision of two configuration of the Elevated Pluz-Maze (EPM) by analizing the exploratory behaviour of female Wistar rats in different phases of the estrous cycle in EPMs with different gradients of luminosity between the open and enclosed arms (O/E∆Lux).Methods Female Wistar rats were treated with Midazolam (MDZ, 1.0 mg.kg-1) and were tested for their exploratory behaviour in either the EPM 10 O/E∆Lux or EPM 96 O/E∆Lux.Results A multiple regression analysis indicated that the O/E∆Lux is negatively associated with the %Open arm entries and %Open arm time, suggesting that as O/E∆Lux increases, the open arm exploration decreases. The estrous cycle phase did not influence the open-arm exploration in either EPM. MDZ- induced anxiolysis was detected in 96 O/E∆Lux EPM in all phases of the EC.Discussion Results of this study suggest the importance of the O/E∆Lux to establish the arm preference in the EPM, and to preserve the predictive validity of the EPM. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000700601 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000700601 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282X20150088 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.73 n.7 2015 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212777968271360 |