Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats

Detalhes bibliográficos
Autor(a) principal: Sakae,Diana Yae
Data de Publicação: 2015
Outros Autores: Sakae,Thiago Mamoru, Paschoalini,Marta Aparecida, Faria,Moacir Serralvo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000700601
Resumo: Objective This study evaluated the provision of two configuration of the Elevated Pluz-Maze (EPM) by analizing the exploratory behaviour of female Wistar rats in different phases of the estrous cycle in EPMs with different gradients of luminosity between the open and enclosed arms (O/E∆Lux).Methods Female Wistar rats were treated with Midazolam (MDZ, 1.0 mg.kg-1) and were tested for their exploratory behaviour in either the EPM 10 O/E∆Lux or EPM 96 O/E∆Lux.Results A multiple regression analysis indicated that the O/E∆Lux is negatively associated with the %Open arm entries and %Open arm time, suggesting that as O/E∆Lux increases, the open arm exploration decreases. The estrous cycle phase did not influence the open-arm exploration in either EPM. MDZ- induced anxiolysis was detected in 96 O/E∆Lux EPM in all phases of the EC.Discussion Results of this study suggest the importance of the O/E∆Lux to establish the arm preference in the EPM, and to preserve the predictive validity of the EPM.
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spelling Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar ratsestrous cyclefemaleWistar ratsanxietyfearelevated plus-mazeluminosityObjective This study evaluated the provision of two configuration of the Elevated Pluz-Maze (EPM) by analizing the exploratory behaviour of female Wistar rats in different phases of the estrous cycle in EPMs with different gradients of luminosity between the open and enclosed arms (O/E∆Lux).Methods Female Wistar rats were treated with Midazolam (MDZ, 1.0 mg.kg-1) and were tested for their exploratory behaviour in either the EPM 10 O/E∆Lux or EPM 96 O/E∆Lux.Results A multiple regression analysis indicated that the O/E∆Lux is negatively associated with the %Open arm entries and %Open arm time, suggesting that as O/E∆Lux increases, the open arm exploration decreases. The estrous cycle phase did not influence the open-arm exploration in either EPM. MDZ- induced anxiolysis was detected in 96 O/E∆Lux EPM in all phases of the EC.Discussion Results of this study suggest the importance of the O/E∆Lux to establish the arm preference in the EPM, and to preserve the predictive validity of the EPM.Academia Brasileira de Neurologia - ABNEURO2015-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000700601Arquivos de Neuro-Psiquiatria v.73 n.7 2015reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20150088info:eu-repo/semantics/openAccessSakae,Diana YaeSakae,Thiago MamoruPaschoalini,Marta AparecidaFaria,Moacir Serralvoeng2015-07-16T00:00:00Zoai:scielo:S0004-282X2015000700601Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2015-07-16T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats
title Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats
spellingShingle Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats
Sakae,Diana Yae
estrous cycle
female
Wistar rats
anxiety
fear
elevated plus-maze
luminosity
title_short Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats
title_full Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats
title_fullStr Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats
title_full_unstemmed Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats
title_sort Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats
author Sakae,Diana Yae
author_facet Sakae,Diana Yae
Sakae,Thiago Mamoru
Paschoalini,Marta Aparecida
Faria,Moacir Serralvo
author_role author
author2 Sakae,Thiago Mamoru
Paschoalini,Marta Aparecida
Faria,Moacir Serralvo
author2_role author
author
author
dc.contributor.author.fl_str_mv Sakae,Diana Yae
Sakae,Thiago Mamoru
Paschoalini,Marta Aparecida
Faria,Moacir Serralvo
dc.subject.por.fl_str_mv estrous cycle
female
Wistar rats
anxiety
fear
elevated plus-maze
luminosity
topic estrous cycle
female
Wistar rats
anxiety
fear
elevated plus-maze
luminosity
description Objective This study evaluated the provision of two configuration of the Elevated Pluz-Maze (EPM) by analizing the exploratory behaviour of female Wistar rats in different phases of the estrous cycle in EPMs with different gradients of luminosity between the open and enclosed arms (O/E∆Lux).Methods Female Wistar rats were treated with Midazolam (MDZ, 1.0 mg.kg-1) and were tested for their exploratory behaviour in either the EPM 10 O/E∆Lux or EPM 96 O/E∆Lux.Results A multiple regression analysis indicated that the O/E∆Lux is negatively associated with the %Open arm entries and %Open arm time, suggesting that as O/E∆Lux increases, the open arm exploration decreases. The estrous cycle phase did not influence the open-arm exploration in either EPM. MDZ- induced anxiolysis was detected in 96 O/E∆Lux EPM in all phases of the EC.Discussion Results of this study suggest the importance of the O/E∆Lux to establish the arm preference in the EPM, and to preserve the predictive validity of the EPM.
publishDate 2015
dc.date.none.fl_str_mv 2015-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000700601
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000700601
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282X20150088
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.73 n.7 2015
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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