sICAM-1 in meningoencephalitis due to Angiostrongylus cantonensis

• Autor(a) principal: Dorta-Contreras,Alberto Juan
• Data de Publicação: 2006
• Outros Autores: Lewczuc,Piotr, Noris-García,Elena, Interián-Morales,María Teresa, Magraner Tarrau,María Esther, Padilla-Docal,Bárbara, Escobar-Pérez,Xiomara
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos de neuro-psiquiatria (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000400011
• topic: Angiostrongylus cantonensis; albumin; sICAM-1; blood-cerebrospinal fluid barrier; eosinophils; meningoencephalitis

INTRODUCTION: Angiostrongylus cantonensis meningoencephalitis is an emergent disease in the Americas. METHOD: Twelve children suffering from eosinophilic meningoencephalitis due to this parasite aged between 6-10 years were studied. Cerebrospinal fluid (CSF) and serum samples were taken simultaneously in the first diagnostic puncture at admission. RESULTS: All cases showed typical findings on the routine CSF and serum analysis: increased CSF total protein, increased Q (CSF/serum) albumin accompanied by eosinophilia in CSF. No intrathecal synthesis of immunoglobulins was found. Mean serum and CSF sICAM-1 values were 337.4 and 3.97 ng/mL. Qalbumin and QsICAM-1 mean values were 4.1 and 6.2 respectively. In 50% of the patients an increased brain-derived fraction of sICAM-1 was found. CONCLUSION: It may be suggested that a dynamic of the sICAM-1 brain derived fraction is perhaps associated to the immune response in the evolution of the disease.sICAM-1 may be an agent in negative feedback for eosinophils passage through the blood-CSF barrier into the inflammatory brain response.