Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis

Detalhes bibliográficos
Autor(a) principal: Sato,Douglas Kazutoshi
Data de Publicação: 2014
Outros Autores: Callegaro,Dagoberto, Lana-Peixoto,Marco Aurélio, Nakashima,Ichiro, Fujihara,Kazuo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000600445
Resumo: Neuromyelitis optica spectrum disorders (NMOSD) are characterized by severe optic neuritis and/or longitudinally extensive transverse myelitis, and some brain lesions are also unique to NMOSD. Serum autoantibodies against aquaporin-4 (AQP4) are detected in most cases of NMOSD. However, some patients with NMOSD remain seronegative despite repetitive testing during attacks with highly sensitive cell-based assays. The differential diagnosis of NMOSD is not restricted to multiple sclerosis and it includes many diseases that can produce longitudinally extensive myelitis and/or optic neuritis. We review the clinical features, imaging, and laboratory findings that can be helpful on the diagnostic work-up, discuss the differences between AQP4 antibody positive and negative patients with NMOSD, including features of NMOSD with antibodies against myelin oligodendrocyte glycoprotein.
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spelling Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesisneuromyelitis opticaaquaporin-4myelin oligodendrocyte glycoproteinantibodymyelitisoptic neuritisdifferential diagnosisNeuromyelitis optica spectrum disorders (NMOSD) are characterized by severe optic neuritis and/or longitudinally extensive transverse myelitis, and some brain lesions are also unique to NMOSD. Serum autoantibodies against aquaporin-4 (AQP4) are detected in most cases of NMOSD. However, some patients with NMOSD remain seronegative despite repetitive testing during attacks with highly sensitive cell-based assays. The differential diagnosis of NMOSD is not restricted to multiple sclerosis and it includes many diseases that can produce longitudinally extensive myelitis and/or optic neuritis. We review the clinical features, imaging, and laboratory findings that can be helpful on the diagnostic work-up, discuss the differences between AQP4 antibody positive and negative patients with NMOSD, including features of NMOSD with antibodies against myelin oligodendrocyte glycoprotein.Academia Brasileira de Neurologia - ABNEURO2014-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000600445Arquivos de Neuro-Psiquiatria v.72 n.6 2014reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20140032info:eu-repo/semantics/openAccessSato,Douglas KazutoshiCallegaro,DagobertoLana-Peixoto,Marco AurélioNakashima,IchiroFujihara,Kazuoeng2014-06-16T00:00:00Zoai:scielo:S0004-282X2014000600445Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2014-06-16T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis
title Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis
spellingShingle Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis
Sato,Douglas Kazutoshi
neuromyelitis optica
aquaporin-4
myelin oligodendrocyte glycoprotein
antibody
myelitis
optic neuritis
differential diagnosis
title_short Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis
title_full Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis
title_fullStr Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis
title_full_unstemmed Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis
title_sort Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis
author Sato,Douglas Kazutoshi
author_facet Sato,Douglas Kazutoshi
Callegaro,Dagoberto
Lana-Peixoto,Marco Aurélio
Nakashima,Ichiro
Fujihara,Kazuo
author_role author
author2 Callegaro,Dagoberto
Lana-Peixoto,Marco Aurélio
Nakashima,Ichiro
Fujihara,Kazuo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Sato,Douglas Kazutoshi
Callegaro,Dagoberto
Lana-Peixoto,Marco Aurélio
Nakashima,Ichiro
Fujihara,Kazuo
dc.subject.por.fl_str_mv neuromyelitis optica
aquaporin-4
myelin oligodendrocyte glycoprotein
antibody
myelitis
optic neuritis
differential diagnosis
topic neuromyelitis optica
aquaporin-4
myelin oligodendrocyte glycoprotein
antibody
myelitis
optic neuritis
differential diagnosis
description Neuromyelitis optica spectrum disorders (NMOSD) are characterized by severe optic neuritis and/or longitudinally extensive transverse myelitis, and some brain lesions are also unique to NMOSD. Serum autoantibodies against aquaporin-4 (AQP4) are detected in most cases of NMOSD. However, some patients with NMOSD remain seronegative despite repetitive testing during attacks with highly sensitive cell-based assays. The differential diagnosis of NMOSD is not restricted to multiple sclerosis and it includes many diseases that can produce longitudinally extensive myelitis and/or optic neuritis. We review the clinical features, imaging, and laboratory findings that can be helpful on the diagnostic work-up, discuss the differences between AQP4 antibody positive and negative patients with NMOSD, including features of NMOSD with antibodies against myelin oligodendrocyte glycoprotein.
publishDate 2014
dc.date.none.fl_str_mv 2014-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000600445
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000600445
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282X20140032
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.72 n.6 2014
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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