Using clinical data to predict sleep hypoxemia in patients with acromegaly
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000200009 |
Resumo: | Hypoxemia secondary to sleep apnea is commonly seen in patients with acromegaly, and this alteration apparently leads to considerable morbidity and mortality among such patients. With the objective of identifying hypoxemia based on clinical data, we conducted a cross-sectional study of 34 patients with acromegaly, all of whom were submitted to nocturnal oximetry and evaluation of snoring, as well as to the determination of body mass index (BMI) and neck circumference. In addition, daytime sleepiness was evaluated using the Epworth sleepiness scale (ESS). In this study, sleep hypoxemia was defined as five or more episodes of desaturation per hour. The sensitivity and specificity of the various parameters in predicting such hypoxemia were, respectively, as follows: snoring (92.9% and 35%); BMI >28.5 kg/m² (71.4% and 60%); neck circumference >44 cm (28.6% and 95%); ESS score >10 (42.9% and 70%). For patients with a neck circumference of more than 44 cm, the probability of sleep hypoxemia was found to increase from 41% (pre-test) to 80% (post-test). For patients with a neck circumference of less than 44 cm, positivity for two or three of the other parameters (snoring, ESS score >10 and BMI >28.5 kg/m²) increased the post-test probability to 62%, whereas positivity for only one (or none) reduced post-test probability to 8%. We can conclude that the clinical parameters evaluated allowed us to predict, with considerable accuracy, whether or not sleep hypoxemia would occur in patients with acromegaly. |
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Using clinical data to predict sleep hypoxemia in patients with acromegalysleep apneaacromegalyhypoxemiaHypoxemia secondary to sleep apnea is commonly seen in patients with acromegaly, and this alteration apparently leads to considerable morbidity and mortality among such patients. With the objective of identifying hypoxemia based on clinical data, we conducted a cross-sectional study of 34 patients with acromegaly, all of whom were submitted to nocturnal oximetry and evaluation of snoring, as well as to the determination of body mass index (BMI) and neck circumference. In addition, daytime sleepiness was evaluated using the Epworth sleepiness scale (ESS). In this study, sleep hypoxemia was defined as five or more episodes of desaturation per hour. The sensitivity and specificity of the various parameters in predicting such hypoxemia were, respectively, as follows: snoring (92.9% and 35%); BMI >28.5 kg/m² (71.4% and 60%); neck circumference >44 cm (28.6% and 95%); ESS score >10 (42.9% and 70%). For patients with a neck circumference of more than 44 cm, the probability of sleep hypoxemia was found to increase from 41% (pre-test) to 80% (post-test). For patients with a neck circumference of less than 44 cm, positivity for two or three of the other parameters (snoring, ESS score >10 and BMI >28.5 kg/m²) increased the post-test probability to 62%, whereas positivity for only one (or none) reduced post-test probability to 8%. We can conclude that the clinical parameters evaluated allowed us to predict, with considerable accuracy, whether or not sleep hypoxemia would occur in patients with acromegaly.Academia Brasileira de Neurologia - ABNEURO2007-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000200009Arquivos de Neuro-Psiquiatria v.65 n.2A 2007reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2007000200009info:eu-repo/semantics/openAccessRodrigues,Marcelo PalmeiraNaves,Luciana AnsanelliCasulari,Luiz AugustoSilva,César Augusto Melo eAraújo,Renata Rodrigues deViegas,Carlos Alberto de Assiseng2010-05-05T00:00:00Zoai:scielo:S0004-282X2007000200009Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2010-05-05T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Using clinical data to predict sleep hypoxemia in patients with acromegaly |
title |
Using clinical data to predict sleep hypoxemia in patients with acromegaly |
spellingShingle |
Using clinical data to predict sleep hypoxemia in patients with acromegaly Rodrigues,Marcelo Palmeira sleep apnea acromegaly hypoxemia |
title_short |
Using clinical data to predict sleep hypoxemia in patients with acromegaly |
title_full |
Using clinical data to predict sleep hypoxemia in patients with acromegaly |
title_fullStr |
Using clinical data to predict sleep hypoxemia in patients with acromegaly |
title_full_unstemmed |
Using clinical data to predict sleep hypoxemia in patients with acromegaly |
title_sort |
Using clinical data to predict sleep hypoxemia in patients with acromegaly |
author |
Rodrigues,Marcelo Palmeira |
author_facet |
Rodrigues,Marcelo Palmeira Naves,Luciana Ansanelli Casulari,Luiz Augusto Silva,César Augusto Melo e Araújo,Renata Rodrigues de Viegas,Carlos Alberto de Assis |
author_role |
author |
author2 |
Naves,Luciana Ansanelli Casulari,Luiz Augusto Silva,César Augusto Melo e Araújo,Renata Rodrigues de Viegas,Carlos Alberto de Assis |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Rodrigues,Marcelo Palmeira Naves,Luciana Ansanelli Casulari,Luiz Augusto Silva,César Augusto Melo e Araújo,Renata Rodrigues de Viegas,Carlos Alberto de Assis |
dc.subject.por.fl_str_mv |
sleep apnea acromegaly hypoxemia |
topic |
sleep apnea acromegaly hypoxemia |
description |
Hypoxemia secondary to sleep apnea is commonly seen in patients with acromegaly, and this alteration apparently leads to considerable morbidity and mortality among such patients. With the objective of identifying hypoxemia based on clinical data, we conducted a cross-sectional study of 34 patients with acromegaly, all of whom were submitted to nocturnal oximetry and evaluation of snoring, as well as to the determination of body mass index (BMI) and neck circumference. In addition, daytime sleepiness was evaluated using the Epworth sleepiness scale (ESS). In this study, sleep hypoxemia was defined as five or more episodes of desaturation per hour. The sensitivity and specificity of the various parameters in predicting such hypoxemia were, respectively, as follows: snoring (92.9% and 35%); BMI >28.5 kg/m² (71.4% and 60%); neck circumference >44 cm (28.6% and 95%); ESS score >10 (42.9% and 70%). For patients with a neck circumference of more than 44 cm, the probability of sleep hypoxemia was found to increase from 41% (pre-test) to 80% (post-test). For patients with a neck circumference of less than 44 cm, positivity for two or three of the other parameters (snoring, ESS score >10 and BMI >28.5 kg/m²) increased the post-test probability to 62%, whereas positivity for only one (or none) reduced post-test probability to 8%. We can conclude that the clinical parameters evaluated allowed us to predict, with considerable accuracy, whether or not sleep hypoxemia would occur in patients with acromegaly. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000200009 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000200009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2007000200009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.65 n.2A 2007 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
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