Clinical characteristics in subcortical ischemic white matter disease

Detalhes bibliográficos
Autor(a) principal: Alves,Gilberto Sousa
Data de Publicação: 2009
Outros Autores: Alves,Carlos Eduardo de Oliveira, Lanna,Maria Elisa de Oliveira, Ericeira-Valente,Letice, Sudo,Felipe Kenji, Moreira,Denise, Engelhardt,Eliasz, Laks,Jerson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000200001
Resumo: BACKGROUND: Vascular white matter lesions (WML) represent one of the main neuroimage findings in individuals older than 65 years and its clinical significance is still partially understood. OBJECTIVE: To describe and analyze the clinical profile of a high severity sample with WML focusing on the frontal executive control. METHOD: Outpatients (n=20) with high severity WML evaluated with magnetic resonance imaging were selected using the Fazekas scale. RESULTS: Most patients (n=17; 85%) presented an altered Trail Making Test ratio (section B/section A); on verbal fluency, 15 individuals (75%) performed below the cutoff score. Apathy (5.9 ± 4.65) and depression (3.05±3.67) were frequent as assessed by the Neuropsychiatric Inventory. The impairment in functional activities strongly correlated with apathy (r=0.814, p<0.001) and verbal fluency (r=0.744, p<0.001). CONCLUSION: Executive dysfunction, apathy, and ratio depression were the main characteristics found. Extension of WML may have distinct impact on the clinical picture, but further studies with methodological adjustments are necessary to provide more definitive conclusions.
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spelling Clinical characteristics in subcortical ischemic white matter diseaseneuropsychologycognitionbehaviorfunctionvascular dementiawhite matter lesionsBACKGROUND: Vascular white matter lesions (WML) represent one of the main neuroimage findings in individuals older than 65 years and its clinical significance is still partially understood. OBJECTIVE: To describe and analyze the clinical profile of a high severity sample with WML focusing on the frontal executive control. METHOD: Outpatients (n=20) with high severity WML evaluated with magnetic resonance imaging were selected using the Fazekas scale. RESULTS: Most patients (n=17; 85%) presented an altered Trail Making Test ratio (section B/section A); on verbal fluency, 15 individuals (75%) performed below the cutoff score. Apathy (5.9 ± 4.65) and depression (3.05±3.67) were frequent as assessed by the Neuropsychiatric Inventory. The impairment in functional activities strongly correlated with apathy (r=0.814, p<0.001) and verbal fluency (r=0.744, p<0.001). CONCLUSION: Executive dysfunction, apathy, and ratio depression were the main characteristics found. Extension of WML may have distinct impact on the clinical picture, but further studies with methodological adjustments are necessary to provide more definitive conclusions.Academia Brasileira de Neurologia - ABNEURO2009-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000200001Arquivos de Neuro-Psiquiatria v.67 n.2a 2009reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2009000200001info:eu-repo/semantics/openAccessAlves,Gilberto SousaAlves,Carlos Eduardo de OliveiraLanna,Maria Elisa de OliveiraEriceira-Valente,LeticeSudo,Felipe KenjiMoreira,DeniseEngelhardt,EliaszLaks,Jersoneng2009-06-05T00:00:00Zoai:scielo:S0004-282X2009000200001Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2009-06-05T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Clinical characteristics in subcortical ischemic white matter disease
title Clinical characteristics in subcortical ischemic white matter disease
spellingShingle Clinical characteristics in subcortical ischemic white matter disease
Alves,Gilberto Sousa
neuropsychology
cognition
behavior
function
vascular dementia
white matter lesions
title_short Clinical characteristics in subcortical ischemic white matter disease
title_full Clinical characteristics in subcortical ischemic white matter disease
title_fullStr Clinical characteristics in subcortical ischemic white matter disease
title_full_unstemmed Clinical characteristics in subcortical ischemic white matter disease
title_sort Clinical characteristics in subcortical ischemic white matter disease
author Alves,Gilberto Sousa
author_facet Alves,Gilberto Sousa
Alves,Carlos Eduardo de Oliveira
Lanna,Maria Elisa de Oliveira
Ericeira-Valente,Letice
Sudo,Felipe Kenji
Moreira,Denise
Engelhardt,Eliasz
Laks,Jerson
author_role author
author2 Alves,Carlos Eduardo de Oliveira
Lanna,Maria Elisa de Oliveira
Ericeira-Valente,Letice
Sudo,Felipe Kenji
Moreira,Denise
Engelhardt,Eliasz
Laks,Jerson
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Alves,Gilberto Sousa
Alves,Carlos Eduardo de Oliveira
Lanna,Maria Elisa de Oliveira
Ericeira-Valente,Letice
Sudo,Felipe Kenji
Moreira,Denise
Engelhardt,Eliasz
Laks,Jerson
dc.subject.por.fl_str_mv neuropsychology
cognition
behavior
function
vascular dementia
white matter lesions
topic neuropsychology
cognition
behavior
function
vascular dementia
white matter lesions
description BACKGROUND: Vascular white matter lesions (WML) represent one of the main neuroimage findings in individuals older than 65 years and its clinical significance is still partially understood. OBJECTIVE: To describe and analyze the clinical profile of a high severity sample with WML focusing on the frontal executive control. METHOD: Outpatients (n=20) with high severity WML evaluated with magnetic resonance imaging were selected using the Fazekas scale. RESULTS: Most patients (n=17; 85%) presented an altered Trail Making Test ratio (section B/section A); on verbal fluency, 15 individuals (75%) performed below the cutoff score. Apathy (5.9 ± 4.65) and depression (3.05±3.67) were frequent as assessed by the Neuropsychiatric Inventory. The impairment in functional activities strongly correlated with apathy (r=0.814, p<0.001) and verbal fluency (r=0.744, p<0.001). CONCLUSION: Executive dysfunction, apathy, and ratio depression were the main characteristics found. Extension of WML may have distinct impact on the clinical picture, but further studies with methodological adjustments are necessary to provide more definitive conclusions.
publishDate 2009
dc.date.none.fl_str_mv 2009-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000200001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000200001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2009000200001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.67 n.2a 2009
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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