Clinical characteristics in subcortical ischemic white matter disease
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000200001 |
Resumo: | BACKGROUND: Vascular white matter lesions (WML) represent one of the main neuroimage findings in individuals older than 65 years and its clinical significance is still partially understood. OBJECTIVE: To describe and analyze the clinical profile of a high severity sample with WML focusing on the frontal executive control. METHOD: Outpatients (n=20) with high severity WML evaluated with magnetic resonance imaging were selected using the Fazekas scale. RESULTS: Most patients (n=17; 85%) presented an altered Trail Making Test ratio (section B/section A); on verbal fluency, 15 individuals (75%) performed below the cutoff score. Apathy (5.9 ± 4.65) and depression (3.05±3.67) were frequent as assessed by the Neuropsychiatric Inventory. The impairment in functional activities strongly correlated with apathy (r=0.814, p<0.001) and verbal fluency (r=0.744, p<0.001). CONCLUSION: Executive dysfunction, apathy, and ratio depression were the main characteristics found. Extension of WML may have distinct impact on the clinical picture, but further studies with methodological adjustments are necessary to provide more definitive conclusions. |
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Clinical characteristics in subcortical ischemic white matter diseaseneuropsychologycognitionbehaviorfunctionvascular dementiawhite matter lesionsBACKGROUND: Vascular white matter lesions (WML) represent one of the main neuroimage findings in individuals older than 65 years and its clinical significance is still partially understood. OBJECTIVE: To describe and analyze the clinical profile of a high severity sample with WML focusing on the frontal executive control. METHOD: Outpatients (n=20) with high severity WML evaluated with magnetic resonance imaging were selected using the Fazekas scale. RESULTS: Most patients (n=17; 85%) presented an altered Trail Making Test ratio (section B/section A); on verbal fluency, 15 individuals (75%) performed below the cutoff score. Apathy (5.9 ± 4.65) and depression (3.05±3.67) were frequent as assessed by the Neuropsychiatric Inventory. The impairment in functional activities strongly correlated with apathy (r=0.814, p<0.001) and verbal fluency (r=0.744, p<0.001). CONCLUSION: Executive dysfunction, apathy, and ratio depression were the main characteristics found. Extension of WML may have distinct impact on the clinical picture, but further studies with methodological adjustments are necessary to provide more definitive conclusions.Academia Brasileira de Neurologia - ABNEURO2009-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000200001Arquivos de Neuro-Psiquiatria v.67 n.2a 2009reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2009000200001info:eu-repo/semantics/openAccessAlves,Gilberto SousaAlves,Carlos Eduardo de OliveiraLanna,Maria Elisa de OliveiraEriceira-Valente,LeticeSudo,Felipe KenjiMoreira,DeniseEngelhardt,EliaszLaks,Jersoneng2009-06-05T00:00:00Zoai:scielo:S0004-282X2009000200001Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2009-06-05T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Clinical characteristics in subcortical ischemic white matter disease |
title |
Clinical characteristics in subcortical ischemic white matter disease |
spellingShingle |
Clinical characteristics in subcortical ischemic white matter disease Alves,Gilberto Sousa neuropsychology cognition behavior function vascular dementia white matter lesions |
title_short |
Clinical characteristics in subcortical ischemic white matter disease |
title_full |
Clinical characteristics in subcortical ischemic white matter disease |
title_fullStr |
Clinical characteristics in subcortical ischemic white matter disease |
title_full_unstemmed |
Clinical characteristics in subcortical ischemic white matter disease |
title_sort |
Clinical characteristics in subcortical ischemic white matter disease |
author |
Alves,Gilberto Sousa |
author_facet |
Alves,Gilberto Sousa Alves,Carlos Eduardo de Oliveira Lanna,Maria Elisa de Oliveira Ericeira-Valente,Letice Sudo,Felipe Kenji Moreira,Denise Engelhardt,Eliasz Laks,Jerson |
author_role |
author |
author2 |
Alves,Carlos Eduardo de Oliveira Lanna,Maria Elisa de Oliveira Ericeira-Valente,Letice Sudo,Felipe Kenji Moreira,Denise Engelhardt,Eliasz Laks,Jerson |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Alves,Gilberto Sousa Alves,Carlos Eduardo de Oliveira Lanna,Maria Elisa de Oliveira Ericeira-Valente,Letice Sudo,Felipe Kenji Moreira,Denise Engelhardt,Eliasz Laks,Jerson |
dc.subject.por.fl_str_mv |
neuropsychology cognition behavior function vascular dementia white matter lesions |
topic |
neuropsychology cognition behavior function vascular dementia white matter lesions |
description |
BACKGROUND: Vascular white matter lesions (WML) represent one of the main neuroimage findings in individuals older than 65 years and its clinical significance is still partially understood. OBJECTIVE: To describe and analyze the clinical profile of a high severity sample with WML focusing on the frontal executive control. METHOD: Outpatients (n=20) with high severity WML evaluated with magnetic resonance imaging were selected using the Fazekas scale. RESULTS: Most patients (n=17; 85%) presented an altered Trail Making Test ratio (section B/section A); on verbal fluency, 15 individuals (75%) performed below the cutoff score. Apathy (5.9 ± 4.65) and depression (3.05±3.67) were frequent as assessed by the Neuropsychiatric Inventory. The impairment in functional activities strongly correlated with apathy (r=0.814, p<0.001) and verbal fluency (r=0.744, p<0.001). CONCLUSION: Executive dysfunction, apathy, and ratio depression were the main characteristics found. Extension of WML may have distinct impact on the clinical picture, but further studies with methodological adjustments are necessary to provide more definitive conclusions. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000200001 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000200001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2009000200001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.67 n.2a 2009 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
_version_ |
1754212765509091328 |