Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001200856 |
Resumo: | Objective To evaluate the utilization profile of antiepileptic drugs in a population of adult patients with refractory epilepsy attending a tertiary center. Method Descriptive analyses of data were obtained from the medical records of 112 patients. Other clinical and demographic characteristics were also registered. Results Polytherapies with ≥3 antiepileptic drugs were prescribed to 60.7% of patients. Of the old agents, carbamazepine and clobazam were the most commonly prescribed (72.3% and 58.9% of the patients, respectively). Among the new agents, lamotrigine was the most commonly prescribed (36.6% of the patients). At least one old agent was identified in 103 out of the 104 polytherapies, while at least one new agent was prescribed to 70.5% of the population. The most prevalent combination was carbamazepine + clobazam + lamotrigine. The mean AED load found was 3.3 (range 0.4–7.7). Conclusion The pattern of use of individual drugs, although consistent with current treatment guidelines, is strongly influenced by the public health system. |
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Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral centerepilepsyrefractory epilepsyantiepileptic drugspolytherapydrug utilization Objective To evaluate the utilization profile of antiepileptic drugs in a population of adult patients with refractory epilepsy attending a tertiary center. Method Descriptive analyses of data were obtained from the medical records of 112 patients. Other clinical and demographic characteristics were also registered. Results Polytherapies with ≥3 antiepileptic drugs were prescribed to 60.7% of patients. Of the old agents, carbamazepine and clobazam were the most commonly prescribed (72.3% and 58.9% of the patients, respectively). Among the new agents, lamotrigine was the most commonly prescribed (36.6% of the patients). At least one old agent was identified in 103 out of the 104 polytherapies, while at least one new agent was prescribed to 70.5% of the population. The most prevalent combination was carbamazepine + clobazam + lamotrigine. The mean AED load found was 3.3 (range 0.4–7.7). Conclusion The pattern of use of individual drugs, although consistent with current treatment guidelines, is strongly influenced by the public health system. Academia Brasileira de Neurologia - ABNEURO2013-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001200856Arquivos de Neuro-Psiquiatria v.71 n.11 2013reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20130169info:eu-repo/semantics/openAccessFreitas-Lima,Priscila deBaldoni,Andre de OliveiraAlexandre,VerianoPereira,Leonardo Regis LeiraSakamoto,Americo Ceikieng2013-11-22T00:00:00Zoai:scielo:S0004-282X2013001200856Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2013-11-22T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center |
title |
Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center |
spellingShingle |
Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center Freitas-Lima,Priscila de epilepsy refractory epilepsy antiepileptic drugs polytherapy drug utilization |
title_short |
Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center |
title_full |
Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center |
title_fullStr |
Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center |
title_full_unstemmed |
Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center |
title_sort |
Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center |
author |
Freitas-Lima,Priscila de |
author_facet |
Freitas-Lima,Priscila de Baldoni,Andre de Oliveira Alexandre,Veriano Pereira,Leonardo Regis Leira Sakamoto,Americo Ceiki |
author_role |
author |
author2 |
Baldoni,Andre de Oliveira Alexandre,Veriano Pereira,Leonardo Regis Leira Sakamoto,Americo Ceiki |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Freitas-Lima,Priscila de Baldoni,Andre de Oliveira Alexandre,Veriano Pereira,Leonardo Regis Leira Sakamoto,Americo Ceiki |
dc.subject.por.fl_str_mv |
epilepsy refractory epilepsy antiepileptic drugs polytherapy drug utilization |
topic |
epilepsy refractory epilepsy antiepileptic drugs polytherapy drug utilization |
description |
Objective To evaluate the utilization profile of antiepileptic drugs in a population of adult patients with refractory epilepsy attending a tertiary center. Method Descriptive analyses of data were obtained from the medical records of 112 patients. Other clinical and demographic characteristics were also registered. Results Polytherapies with ≥3 antiepileptic drugs were prescribed to 60.7% of patients. Of the old agents, carbamazepine and clobazam were the most commonly prescribed (72.3% and 58.9% of the patients, respectively). Among the new agents, lamotrigine was the most commonly prescribed (36.6% of the patients). At least one old agent was identified in 103 out of the 104 polytherapies, while at least one new agent was prescribed to 70.5% of the population. The most prevalent combination was carbamazepine + clobazam + lamotrigine. The mean AED load found was 3.3 (range 0.4–7.7). Conclusion The pattern of use of individual drugs, although consistent with current treatment guidelines, is strongly influenced by the public health system. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001200856 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001200856 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282X20130169 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.71 n.11 2013 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212775374094336 |