Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center

Detalhes bibliográficos
Autor(a) principal: Freitas-Lima,Priscila de
Data de Publicação: 2013
Outros Autores: Baldoni,Andre de Oliveira, Alexandre,Veriano, Pereira,Leonardo Regis Leira, Sakamoto,Americo Ceiki
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001200856
Resumo: Objective To evaluate the utilization profile of antiepileptic drugs in a population of adult patients with refractory epilepsy attending a tertiary center. Method Descriptive analyses of data were obtained from the medical records of 112 patients. Other clinical and demographic characteristics were also registered. Results Polytherapies with ≥3 antiepileptic drugs were prescribed to 60.7% of patients. Of the old agents, carbamazepine and clobazam were the most commonly prescribed (72.3% and 58.9% of the patients, respectively). Among the new agents, lamotrigine was the most commonly prescribed (36.6% of the patients). At least one old agent was identified in 103 out of the 104 polytherapies, while at least one new agent was prescribed to 70.5% of the population. The most prevalent combination was carbamazepine + clobazam + lamotrigine. The mean AED load found was 3.3 (range 0.4–7.7). Conclusion The pattern of use of individual drugs, although consistent with current treatment guidelines, is strongly influenced by the public health system.
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spelling Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral centerepilepsyrefractory epilepsyantiepileptic drugspolytherapydrug utilization Objective To evaluate the utilization profile of antiepileptic drugs in a population of adult patients with refractory epilepsy attending a tertiary center. Method Descriptive analyses of data were obtained from the medical records of 112 patients. Other clinical and demographic characteristics were also registered. Results Polytherapies with ≥3 antiepileptic drugs were prescribed to 60.7% of patients. Of the old agents, carbamazepine and clobazam were the most commonly prescribed (72.3% and 58.9% of the patients, respectively). Among the new agents, lamotrigine was the most commonly prescribed (36.6% of the patients). At least one old agent was identified in 103 out of the 104 polytherapies, while at least one new agent was prescribed to 70.5% of the population. The most prevalent combination was carbamazepine + clobazam + lamotrigine. The mean AED load found was 3.3 (range 0.4–7.7). Conclusion The pattern of use of individual drugs, although consistent with current treatment guidelines, is strongly influenced by the public health system. Academia Brasileira de Neurologia - ABNEURO2013-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001200856Arquivos de Neuro-Psiquiatria v.71 n.11 2013reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20130169info:eu-repo/semantics/openAccessFreitas-Lima,Priscila deBaldoni,Andre de OliveiraAlexandre,VerianoPereira,Leonardo Regis LeiraSakamoto,Americo Ceikieng2013-11-22T00:00:00Zoai:scielo:S0004-282X2013001200856Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2013-11-22T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center
title Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center
spellingShingle Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center
Freitas-Lima,Priscila de
epilepsy
refractory epilepsy
antiepileptic drugs
polytherapy
drug utilization
title_short Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center
title_full Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center
title_fullStr Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center
title_full_unstemmed Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center
title_sort Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center
author Freitas-Lima,Priscila de
author_facet Freitas-Lima,Priscila de
Baldoni,Andre de Oliveira
Alexandre,Veriano
Pereira,Leonardo Regis Leira
Sakamoto,Americo Ceiki
author_role author
author2 Baldoni,Andre de Oliveira
Alexandre,Veriano
Pereira,Leonardo Regis Leira
Sakamoto,Americo Ceiki
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Freitas-Lima,Priscila de
Baldoni,Andre de Oliveira
Alexandre,Veriano
Pereira,Leonardo Regis Leira
Sakamoto,Americo Ceiki
dc.subject.por.fl_str_mv epilepsy
refractory epilepsy
antiepileptic drugs
polytherapy
drug utilization
topic epilepsy
refractory epilepsy
antiepileptic drugs
polytherapy
drug utilization
description Objective To evaluate the utilization profile of antiepileptic drugs in a population of adult patients with refractory epilepsy attending a tertiary center. Method Descriptive analyses of data were obtained from the medical records of 112 patients. Other clinical and demographic characteristics were also registered. Results Polytherapies with ≥3 antiepileptic drugs were prescribed to 60.7% of patients. Of the old agents, carbamazepine and clobazam were the most commonly prescribed (72.3% and 58.9% of the patients, respectively). Among the new agents, lamotrigine was the most commonly prescribed (36.6% of the patients). At least one old agent was identified in 103 out of the 104 polytherapies, while at least one new agent was prescribed to 70.5% of the population. The most prevalent combination was carbamazepine + clobazam + lamotrigine. The mean AED load found was 3.3 (range 0.4–7.7). Conclusion The pattern of use of individual drugs, although consistent with current treatment guidelines, is strongly influenced by the public health system.
publishDate 2013
dc.date.none.fl_str_mv 2013-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001200856
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001200856
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282X20130169
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.71 n.11 2013
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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