Inherited neuromuscular diseases in the mouse: a review of the literature

Detalhes bibliográficos
Autor(a) principal: Torres,Luiz Fernando Bleggi
Data de Publicação: 1988
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1988000300011
Resumo: There are several neuromuscular disorders affecting the human being. Most of these are poorly understood and lack an effective treatment. Due to the limitation of experimental manipulation in «anima nobili», inherited neuromuscular diseases in laboratory animals constitute a valuable source of scientific information. Amongst several animal species affected by neuromuscular disorders the house mouse is of particular interest because of its small size, short pregnancy and low costs of maintanence. In the present review 20 murine mutants with diseases affecting peripheral nerves, skeletal muscles and motor end-plates are tabulated. Genetic, clinical and pathological aspects are discussed aiming to provide information about these mutants which might be of great interest as animal models for human neuromuscular diseases.
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spelling Inherited neuromuscular diseases in the mouse: a review of the literatureThere are several neuromuscular disorders affecting the human being. Most of these are poorly understood and lack an effective treatment. Due to the limitation of experimental manipulation in «anima nobili», inherited neuromuscular diseases in laboratory animals constitute a valuable source of scientific information. Amongst several animal species affected by neuromuscular disorders the house mouse is of particular interest because of its small size, short pregnancy and low costs of maintanence. In the present review 20 murine mutants with diseases affecting peripheral nerves, skeletal muscles and motor end-plates are tabulated. Genetic, clinical and pathological aspects are discussed aiming to provide information about these mutants which might be of great interest as animal models for human neuromuscular diseases.Academia Brasileira de Neurologia - ABNEURO1988-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1988000300011Arquivos de Neuro-Psiquiatria v.46 n.3 1988reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X1988000300011info:eu-repo/semantics/openAccessTorres,Luiz Fernando Bleggieng2011-06-17T00:00:00Zoai:scielo:S0004-282X1988000300011Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2011-06-17T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Inherited neuromuscular diseases in the mouse: a review of the literature
title Inherited neuromuscular diseases in the mouse: a review of the literature
spellingShingle Inherited neuromuscular diseases in the mouse: a review of the literature
Torres,Luiz Fernando Bleggi
title_short Inherited neuromuscular diseases in the mouse: a review of the literature
title_full Inherited neuromuscular diseases in the mouse: a review of the literature
title_fullStr Inherited neuromuscular diseases in the mouse: a review of the literature
title_full_unstemmed Inherited neuromuscular diseases in the mouse: a review of the literature
title_sort Inherited neuromuscular diseases in the mouse: a review of the literature
author Torres,Luiz Fernando Bleggi
author_facet Torres,Luiz Fernando Bleggi
author_role author
dc.contributor.author.fl_str_mv Torres,Luiz Fernando Bleggi
description There are several neuromuscular disorders affecting the human being. Most of these are poorly understood and lack an effective treatment. Due to the limitation of experimental manipulation in «anima nobili», inherited neuromuscular diseases in laboratory animals constitute a valuable source of scientific information. Amongst several animal species affected by neuromuscular disorders the house mouse is of particular interest because of its small size, short pregnancy and low costs of maintanence. In the present review 20 murine mutants with diseases affecting peripheral nerves, skeletal muscles and motor end-plates are tabulated. Genetic, clinical and pathological aspects are discussed aiming to provide information about these mutants which might be of great interest as animal models for human neuromuscular diseases.
publishDate 1988
dc.date.none.fl_str_mv 1988-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1988000300011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1988000300011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X1988000300011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.46 n.3 1988
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
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instname_str Academia Brasileira de Neurologia
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reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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