Carbamazepine kinetics in cardiac patients before and during amiodarone

Detalhes bibliográficos
Autor(a) principal: Leite,Silmara A.O.
Data de Publicação: 1994
Outros Autores: Leite,Paulo J.M., Rocha,Gilberto A., Routledge,Philip A., Bittencourt,Paulo Rogério M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1994000200010
Resumo: Carbamazepine and amiodarone may often be used together, especially in countries where cardiomyopathies are common. In this study single doses of carbamazepine (400 mg) were given to patients with cardiac disease before and after one month of therapy with amiodarone, 400 mg daily. The kinetic profile of carbamazepine, its free fraction, and serum amiodarone, were measured at the two occasions. There was no statistically significant change in carbamazepine kinetics or free fraction, before and after the introduction of amiodarone. The concentrations of amidarone after one month of therapy were low. It is sugested that the possible interaction in the hepatic metabolism was not demonstrated because amiodarone concentrations were not enough to inhibit carbamazepine metabolism.
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spelling Carbamazepine kinetics in cardiac patients before and during amiodaroneamiodaronecarbamazepineepilepsyantiepileptic dragsarrythmiaCarbamazepine and amiodarone may often be used together, especially in countries where cardiomyopathies are common. In this study single doses of carbamazepine (400 mg) were given to patients with cardiac disease before and after one month of therapy with amiodarone, 400 mg daily. The kinetic profile of carbamazepine, its free fraction, and serum amiodarone, were measured at the two occasions. There was no statistically significant change in carbamazepine kinetics or free fraction, before and after the introduction of amiodarone. The concentrations of amidarone after one month of therapy were low. It is sugested that the possible interaction in the hepatic metabolism was not demonstrated because amiodarone concentrations were not enough to inhibit carbamazepine metabolism.Academia Brasileira de Neurologia - ABNEURO1994-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1994000200010Arquivos de Neuro-Psiquiatria v.52 n.2 1994reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X1994000200010info:eu-repo/semantics/openAccessLeite,Silmara A.O.Leite,Paulo J.M.Rocha,Gilberto A.Routledge,Philip A.Bittencourt,Paulo Rogério M.eng2011-01-19T00:00:00Zoai:scielo:S0004-282X1994000200010Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2011-01-19T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Carbamazepine kinetics in cardiac patients before and during amiodarone
title Carbamazepine kinetics in cardiac patients before and during amiodarone
spellingShingle Carbamazepine kinetics in cardiac patients before and during amiodarone
Leite,Silmara A.O.
amiodarone
carbamazepine
epilepsy
antiepileptic drags
arrythmia
title_short Carbamazepine kinetics in cardiac patients before and during amiodarone
title_full Carbamazepine kinetics in cardiac patients before and during amiodarone
title_fullStr Carbamazepine kinetics in cardiac patients before and during amiodarone
title_full_unstemmed Carbamazepine kinetics in cardiac patients before and during amiodarone
title_sort Carbamazepine kinetics in cardiac patients before and during amiodarone
author Leite,Silmara A.O.
author_facet Leite,Silmara A.O.
Leite,Paulo J.M.
Rocha,Gilberto A.
Routledge,Philip A.
Bittencourt,Paulo Rogério M.
author_role author
author2 Leite,Paulo J.M.
Rocha,Gilberto A.
Routledge,Philip A.
Bittencourt,Paulo Rogério M.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Leite,Silmara A.O.
Leite,Paulo J.M.
Rocha,Gilberto A.
Routledge,Philip A.
Bittencourt,Paulo Rogério M.
dc.subject.por.fl_str_mv amiodarone
carbamazepine
epilepsy
antiepileptic drags
arrythmia
topic amiodarone
carbamazepine
epilepsy
antiepileptic drags
arrythmia
description Carbamazepine and amiodarone may often be used together, especially in countries where cardiomyopathies are common. In this study single doses of carbamazepine (400 mg) were given to patients with cardiac disease before and after one month of therapy with amiodarone, 400 mg daily. The kinetic profile of carbamazepine, its free fraction, and serum amiodarone, were measured at the two occasions. There was no statistically significant change in carbamazepine kinetics or free fraction, before and after the introduction of amiodarone. The concentrations of amidarone after one month of therapy were low. It is sugested that the possible interaction in the hepatic metabolism was not demonstrated because amiodarone concentrations were not enough to inhibit carbamazepine metabolism.
publishDate 1994
dc.date.none.fl_str_mv 1994-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1994000200010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1994000200010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X1994000200010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.52 n.2 1994
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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