Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors

Detalhes bibliográficos
Autor(a) principal: HILBIG,ARLETE
Data de Publicação: 1998
Outros Autores: BARBOSA-COUTINHO,LÍGIA MARIA
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1998000200005
Resumo: The authors assessed 116 cases of meningiomas classified as typical, atypical and anaplastic and they used an immunohistochemical technique for estrogen and progesterone receptors attempting to determine if there is any difference between typical and non-typical tumors in relation to hormone receptors. The immunohistochemical technique to estrogen receptors was negative in all meningiomas studied. Progesterone receptors were detected in 58.3% of typical, and in 48.2% of non-typical meningiomas. This difference was not statistically significant. However, individually considering the criteria used for selection of non-typical tumours, those that concurrently displayed brain invasion and increased mitotic activity or necrosis, as well as the summation of those three features, were predominantly negative for progesterone receptors (respectively p=0.038; p=0.001; and p=0.044). The authors conclude that estrogen receptors were not present in meningiomas; that progesterone receptors in isolation are not enough to predict a higher tumoral malignancy but can be useful associated with other histological features.
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spelling Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumorsmeningiomaprogesterone receptorestrogen receptorimmunohistochemistryThe authors assessed 116 cases of meningiomas classified as typical, atypical and anaplastic and they used an immunohistochemical technique for estrogen and progesterone receptors attempting to determine if there is any difference between typical and non-typical tumors in relation to hormone receptors. The immunohistochemical technique to estrogen receptors was negative in all meningiomas studied. Progesterone receptors were detected in 58.3% of typical, and in 48.2% of non-typical meningiomas. This difference was not statistically significant. However, individually considering the criteria used for selection of non-typical tumours, those that concurrently displayed brain invasion and increased mitotic activity or necrosis, as well as the summation of those three features, were predominantly negative for progesterone receptors (respectively p=0.038; p=0.001; and p=0.044). The authors conclude that estrogen receptors were not present in meningiomas; that progesterone receptors in isolation are not enough to predict a higher tumoral malignancy but can be useful associated with other histological features.Academia Brasileira de Neurologia - ABNEURO1998-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1998000200005Arquivos de Neuro-Psiquiatria v.56 n.2 1998reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X1998000200005info:eu-repo/semantics/openAccessHILBIG,ARLETEBARBOSA-COUTINHO,LÍGIA MARIAeng2000-11-10T00:00:00Zoai:scielo:S0004-282X1998000200005Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2000-11-10T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors
title Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors
spellingShingle Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors
HILBIG,ARLETE
meningioma
progesterone receptor
estrogen receptor
immunohistochemistry
title_short Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors
title_full Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors
title_fullStr Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors
title_full_unstemmed Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors
title_sort Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors
author HILBIG,ARLETE
author_facet HILBIG,ARLETE
BARBOSA-COUTINHO,LÍGIA MARIA
author_role author
author2 BARBOSA-COUTINHO,LÍGIA MARIA
author2_role author
dc.contributor.author.fl_str_mv HILBIG,ARLETE
BARBOSA-COUTINHO,LÍGIA MARIA
dc.subject.por.fl_str_mv meningioma
progesterone receptor
estrogen receptor
immunohistochemistry
topic meningioma
progesterone receptor
estrogen receptor
immunohistochemistry
description The authors assessed 116 cases of meningiomas classified as typical, atypical and anaplastic and they used an immunohistochemical technique for estrogen and progesterone receptors attempting to determine if there is any difference between typical and non-typical tumors in relation to hormone receptors. The immunohistochemical technique to estrogen receptors was negative in all meningiomas studied. Progesterone receptors were detected in 58.3% of typical, and in 48.2% of non-typical meningiomas. This difference was not statistically significant. However, individually considering the criteria used for selection of non-typical tumours, those that concurrently displayed brain invasion and increased mitotic activity or necrosis, as well as the summation of those three features, were predominantly negative for progesterone receptors (respectively p=0.038; p=0.001; and p=0.044). The authors conclude that estrogen receptors were not present in meningiomas; that progesterone receptors in isolation are not enough to predict a higher tumoral malignancy but can be useful associated with other histological features.
publishDate 1998
dc.date.none.fl_str_mv 1998-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1998000200005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1998000200005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X1998000200005
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.56 n.2 1998
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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