Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1998000200005 |
Resumo: | The authors assessed 116 cases of meningiomas classified as typical, atypical and anaplastic and they used an immunohistochemical technique for estrogen and progesterone receptors attempting to determine if there is any difference between typical and non-typical tumors in relation to hormone receptors. The immunohistochemical technique to estrogen receptors was negative in all meningiomas studied. Progesterone receptors were detected in 58.3% of typical, and in 48.2% of non-typical meningiomas. This difference was not statistically significant. However, individually considering the criteria used for selection of non-typical tumours, those that concurrently displayed brain invasion and increased mitotic activity or necrosis, as well as the summation of those three features, were predominantly negative for progesterone receptors (respectively p=0.038; p=0.001; and p=0.044). The authors conclude that estrogen receptors were not present in meningiomas; that progesterone receptors in isolation are not enough to predict a higher tumoral malignancy but can be useful associated with other histological features. |
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Arquivos de neuro-psiquiatria (Online) |
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Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumorsmeningiomaprogesterone receptorestrogen receptorimmunohistochemistryThe authors assessed 116 cases of meningiomas classified as typical, atypical and anaplastic and they used an immunohistochemical technique for estrogen and progesterone receptors attempting to determine if there is any difference between typical and non-typical tumors in relation to hormone receptors. The immunohistochemical technique to estrogen receptors was negative in all meningiomas studied. Progesterone receptors were detected in 58.3% of typical, and in 48.2% of non-typical meningiomas. This difference was not statistically significant. However, individually considering the criteria used for selection of non-typical tumours, those that concurrently displayed brain invasion and increased mitotic activity or necrosis, as well as the summation of those three features, were predominantly negative for progesterone receptors (respectively p=0.038; p=0.001; and p=0.044). The authors conclude that estrogen receptors were not present in meningiomas; that progesterone receptors in isolation are not enough to predict a higher tumoral malignancy but can be useful associated with other histological features.Academia Brasileira de Neurologia - ABNEURO1998-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1998000200005Arquivos de Neuro-Psiquiatria v.56 n.2 1998reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X1998000200005info:eu-repo/semantics/openAccessHILBIG,ARLETEBARBOSA-COUTINHO,LÍGIA MARIAeng2000-11-10T00:00:00Zoai:scielo:S0004-282X1998000200005Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2000-11-10T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors |
title |
Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors |
spellingShingle |
Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors HILBIG,ARLETE meningioma progesterone receptor estrogen receptor immunohistochemistry |
title_short |
Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors |
title_full |
Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors |
title_fullStr |
Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors |
title_full_unstemmed |
Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors |
title_sort |
Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors |
author |
HILBIG,ARLETE |
author_facet |
HILBIG,ARLETE BARBOSA-COUTINHO,LÍGIA MARIA |
author_role |
author |
author2 |
BARBOSA-COUTINHO,LÍGIA MARIA |
author2_role |
author |
dc.contributor.author.fl_str_mv |
HILBIG,ARLETE BARBOSA-COUTINHO,LÍGIA MARIA |
dc.subject.por.fl_str_mv |
meningioma progesterone receptor estrogen receptor immunohistochemistry |
topic |
meningioma progesterone receptor estrogen receptor immunohistochemistry |
description |
The authors assessed 116 cases of meningiomas classified as typical, atypical and anaplastic and they used an immunohistochemical technique for estrogen and progesterone receptors attempting to determine if there is any difference between typical and non-typical tumors in relation to hormone receptors. The immunohistochemical technique to estrogen receptors was negative in all meningiomas studied. Progesterone receptors were detected in 58.3% of typical, and in 48.2% of non-typical meningiomas. This difference was not statistically significant. However, individually considering the criteria used for selection of non-typical tumours, those that concurrently displayed brain invasion and increased mitotic activity or necrosis, as well as the summation of those three features, were predominantly negative for progesterone receptors (respectively p=0.038; p=0.001; and p=0.044). The authors conclude that estrogen receptors were not present in meningiomas; that progesterone receptors in isolation are not enough to predict a higher tumoral malignancy but can be useful associated with other histological features. |
publishDate |
1998 |
dc.date.none.fl_str_mv |
1998-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1998000200005 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1998000200005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X1998000200005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.56 n.2 1998 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
_version_ |
1754212750809104384 |