Alzheimer's disease in Brazilian elderly has a relation with homocysteine but not with MTHFR polymorphisms
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000600010 |
Resumo: | OBJECTIVE: To investigate the association between total plasma homocysteine concentration, C677T and A1298C polymorphisms in MTHFR gene and Alzheimer's disease (AD) development. METHOD: Forty-three patients with probable (63%) and possible (37%) AD and 50 non-demented controls were evaluated. Groups did not differ as to gender, age, scholar years, diabetes, alcohol and coffee intake and physical activity. Total plasma homocysteine (Hcy) levels were determined by HPLC and genotyping for MTHFR by PCR/RFLP. Mann-Whitney "U" test was used to compare quantitative variable, Fisher-Freeman-Halton test to compare genotypes and allele proportions and Chi-square test to other qualitative variables. RESULTS: AD patients presented higher total plasma Hcy levels than controls and the difference was statistically significant. No differences in the C677T and A1298C MTHFR polymorphisms distributions were found between patients and controls. Plasma homocysteine concentration did not change with MTHFR genotypes. CONCLUSION: Our data confirms the association between increased plasma Hcy concentration and AD and suggests that neither C677T nor A1298C MTHFR polymorphisms contributed to genetic susceptibility for AD in elderly individuals in the Northeast of Brazil. |
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Alzheimer's disease in Brazilian elderly has a relation with homocysteine but not with MTHFR polymorphismshomocysteineMTHFRAlzheimers diseaseOBJECTIVE: To investigate the association between total plasma homocysteine concentration, C677T and A1298C polymorphisms in MTHFR gene and Alzheimer's disease (AD) development. METHOD: Forty-three patients with probable (63%) and possible (37%) AD and 50 non-demented controls were evaluated. Groups did not differ as to gender, age, scholar years, diabetes, alcohol and coffee intake and physical activity. Total plasma homocysteine (Hcy) levels were determined by HPLC and genotyping for MTHFR by PCR/RFLP. Mann-Whitney "U" test was used to compare quantitative variable, Fisher-Freeman-Halton test to compare genotypes and allele proportions and Chi-square test to other qualitative variables. RESULTS: AD patients presented higher total plasma Hcy levels than controls and the difference was statistically significant. No differences in the C677T and A1298C MTHFR polymorphisms distributions were found between patients and controls. Plasma homocysteine concentration did not change with MTHFR genotypes. CONCLUSION: Our data confirms the association between increased plasma Hcy concentration and AD and suggests that neither C677T nor A1298C MTHFR polymorphisms contributed to genetic susceptibility for AD in elderly individuals in the Northeast of Brazil.Academia Brasileira de Neurologia - ABNEURO2006-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000600010Arquivos de Neuro-Psiquiatria v.64 n.4 2006reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2006000600010info:eu-repo/semantics/openAccessSilva,Vanessa Cavalcante daRamos,Flávio José da CostaFreitas,Elizabete MalaquiasBrito-Marques,Paulo Roberto deCavalcanti,Márcia Nery de HolandaDAlmeida,VâniaCabral-Filho,José EulálioMuniz,Maria Tereza Cartaxoeng2006-12-21T00:00:00Zoai:scielo:S0004-282X2006000600010Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2006-12-21T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Alzheimer's disease in Brazilian elderly has a relation with homocysteine but not with MTHFR polymorphisms |
title |
Alzheimer's disease in Brazilian elderly has a relation with homocysteine but not with MTHFR polymorphisms |
spellingShingle |
Alzheimer's disease in Brazilian elderly has a relation with homocysteine but not with MTHFR polymorphisms Silva,Vanessa Cavalcante da homocysteine MTHFR Alzheimers disease |
title_short |
Alzheimer's disease in Brazilian elderly has a relation with homocysteine but not with MTHFR polymorphisms |
title_full |
Alzheimer's disease in Brazilian elderly has a relation with homocysteine but not with MTHFR polymorphisms |
title_fullStr |
Alzheimer's disease in Brazilian elderly has a relation with homocysteine but not with MTHFR polymorphisms |
title_full_unstemmed |
Alzheimer's disease in Brazilian elderly has a relation with homocysteine but not with MTHFR polymorphisms |
title_sort |
Alzheimer's disease in Brazilian elderly has a relation with homocysteine but not with MTHFR polymorphisms |
author |
Silva,Vanessa Cavalcante da |
author_facet |
Silva,Vanessa Cavalcante da Ramos,Flávio José da Costa Freitas,Elizabete Malaquias Brito-Marques,Paulo Roberto de Cavalcanti,Márcia Nery de Holanda DAlmeida,Vânia Cabral-Filho,José Eulálio Muniz,Maria Tereza Cartaxo |
author_role |
author |
author2 |
Ramos,Flávio José da Costa Freitas,Elizabete Malaquias Brito-Marques,Paulo Roberto de Cavalcanti,Márcia Nery de Holanda DAlmeida,Vânia Cabral-Filho,José Eulálio Muniz,Maria Tereza Cartaxo |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva,Vanessa Cavalcante da Ramos,Flávio José da Costa Freitas,Elizabete Malaquias Brito-Marques,Paulo Roberto de Cavalcanti,Márcia Nery de Holanda DAlmeida,Vânia Cabral-Filho,José Eulálio Muniz,Maria Tereza Cartaxo |
dc.subject.por.fl_str_mv |
homocysteine MTHFR Alzheimers disease |
topic |
homocysteine MTHFR Alzheimers disease |
description |
OBJECTIVE: To investigate the association between total plasma homocysteine concentration, C677T and A1298C polymorphisms in MTHFR gene and Alzheimer's disease (AD) development. METHOD: Forty-three patients with probable (63%) and possible (37%) AD and 50 non-demented controls were evaluated. Groups did not differ as to gender, age, scholar years, diabetes, alcohol and coffee intake and physical activity. Total plasma homocysteine (Hcy) levels were determined by HPLC and genotyping for MTHFR by PCR/RFLP. Mann-Whitney "U" test was used to compare quantitative variable, Fisher-Freeman-Halton test to compare genotypes and allele proportions and Chi-square test to other qualitative variables. RESULTS: AD patients presented higher total plasma Hcy levels than controls and the difference was statistically significant. No differences in the C677T and A1298C MTHFR polymorphisms distributions were found between patients and controls. Plasma homocysteine concentration did not change with MTHFR genotypes. CONCLUSION: Our data confirms the association between increased plasma Hcy concentration and AD and suggests that neither C677T nor A1298C MTHFR polymorphisms contributed to genetic susceptibility for AD in elderly individuals in the Northeast of Brazil. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000600010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000600010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2006000600010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.64 n.4 2006 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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